8-hydroxy-2--deoxyguanosine and Tachycardia--Ventricular

Sudden cardiac death (SCD) is the major cause of death in cardiac sarcoidosis (CS). We aimed to identify the prognostic markers for sustained ventricular tachycardia (sVT) and SCD in patients with CS.. We performed a prospective observational cohort study for patients with CS diagnosed according to the Japanese or Heart Rhythm Society guidelines between June 2008 and March 2020 in our hospital. The primary endpoint was a composite of the first sVT and SCD. The levels of urinary 8-hydroxy-2'-deoxyguanosine (U-8-OHdG), a marker of oxidative DNA damage that reflects the inflammatory activity of CS, other biomarkers, and indices of cardiac function and renal function were measured on admission.. U-8-OHdG and presence of VA were powerful predictors of first sVT/SCD in patients with CS, facilitating the stratification of cardiac events and providing relevant information about the substrates of ventricular tachycardia.

Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Cardiomyopathies; Death, Sudden, Cardiac; Fluorodeoxyglucose F18; Heart Aneurysm; Humans; Myocarditis; Oxidative Stress; Prospective Studies; Risk Factors; Sarcoidosis; Tachycardia, Ventricular

Topics: 8-Hydroxy-2'-Deoxyguanosine; Cardiomyopathies; Deoxyguanosine; Humans; Inflammation; Oxidative Stress; Sarcoidosis; Tachycardia, Ventricular