8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Vomiting in 13 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Doses of naloxone far below those which elicit emesis increase the sensitivity to motion sickness." | 7.85 | Effects of naloxone on motion sickness in cats alone and with broad spectrum antiemetics. ( Lucot, JB, 2017) |
| "To evaluate the hypothesis that activation of somatodendritic 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) produces the anti-emetic/anti-nausea effects of cannabidiol (CBD), a primary non-psychoactive cannabinoid found in cannabis." | 7.78 | Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. ( Anavi-Goffer, S; Bolognini, D; Cascio, MG; Fletcher, PJ; Limebeer, CL; Mechoulam, R; Parker, LA; Pertwee, RG; Rock, EM, 2012) |
| " A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis." | 7.67 | 8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine. ( Crampton, GH; Lucot, JB, 1989) |
| "Doses of naloxone far below those which elicit emesis increase the sensitivity to motion sickness." | 3.85 | Effects of naloxone on motion sickness in cats alone and with broad spectrum antiemetics. ( Lucot, JB, 2017) |
| "To evaluate the hypothesis that activation of somatodendritic 5-HT(1A) autoreceptors in the dorsal raphe nucleus (DRN) produces the anti-emetic/anti-nausea effects of cannabidiol (CBD), a primary non-psychoactive cannabinoid found in cannabis." | 3.78 | Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus. ( Anavi-Goffer, S; Bolognini, D; Cascio, MG; Fletcher, PJ; Limebeer, CL; Mechoulam, R; Parker, LA; Pertwee, RG; Rock, EM, 2012) |
| " Flesinoxan produced a dose-dependent suppression of motion sickness and also reduced xylazine-induced emesis at higher doses." | 3.69 | Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin. ( Lucot, JB, 1994) |
| "The antiemetic effects of six serotonergic 5-HT1A-receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetrarin (8-OH-DPAT), 4-(4-[4-(2-pyrimidinyl)piperazin-1-yl]butyl)-2,3,4,5- tetrahydro-1,4-benzoxazepine-3,5-dione (SUN8399), buspirone, gepirone, ipsapirone and tandospirone, against motion sickness were investigated in Suncus murinus." | 3.69 | Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus. ( Matsuki, N; Okada, F; Saito, H; Torii, Y, 1994) |
| " A supplementary experiment revealed that lorazepam suppressed motion sickness at a dose that produced ataxia, but did not suppress xylazine-induced emesis." | 3.67 | 8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine. ( Crampton, GH; Lucot, JB, 1989) |
| "Pre-treatment with methysergide (a 5-HT(1/2/7) receptor antagonist, 1." | 1.33 | The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus. ( Javid, FA; Naylor, RJ, 2006) |
| "Pretreatment with disulfiram, an inhibitor of liver aldehyde dehydrogenase, potentiated the emetogenic effects of ethanol." | 1.30 | Ethanol-induced emesis in the house musk shrew, Suncus murinus. ( Chen, Y; Matsuki, N; Saito, H, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horn, CC | 1 |
| Zirpel, L | 1 |
| Sciullo, MG | 1 |
| Rosenberg, DM | 1 |
| Lucot, JB | 5 |
| Brame, RE | 1 |
| Rock, EM | 1 |
| Bolognini, D | 1 |
| Limebeer, CL | 1 |
| Cascio, MG | 1 |
| Anavi-Goffer, S | 1 |
| Fletcher, PJ | 1 |
| Mechoulam, R | 1 |
| Pertwee, RG | 1 |
| Parker, LA | 1 |
| Javid, FA | 1 |
| Naylor, RJ | 1 |
| Okada, F | 2 |
| Torii, Y | 2 |
| Saito, H | 3 |
| Matsuki, N | 4 |
| Andrews, P | 1 |
| Chen, Y | 1 |
| Andrews, PL | 1 |
| Woods, AJ | 1 |
| Hagiwara, H | 1 |
| Kakaimoto, S | 1 |
| Toyoda, M | 1 |
| McDermed, JD | 1 |
| McKenzie, GM | 1 |
| Freeman, HS | 1 |
| Crampton, GH | 2 |
13 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Vomiting
| Article | Year |
|---|---|
Impact of electrical stimulation of the stomach on gastric distension-induced emesis in the musk shrew.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiemetics; Blood Pressure; Electric Stimulation; | 2016 |
Effects of naloxone on motion sickness in cats alone and with broad spectrum antiemetics.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiemetics; Cats; Dose-Response Relationship, Drug | 2017 |
Guamanian Suncus murinus responsiveness to emetic stimuli and the antiemetic effects of 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiemetics; Female; Male; Motion Sickness; Shrews; | 2011 |
Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiemetics; Behavior, Animal; Cannabidiol; Cannabi | 2012 |
The effect of the 5-HT1A receptor agonist, 8-OH-DPAT, on motion-induced emesis in Suncus murinus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Male; Methysergide; Motion; Ondansetron; Ph | 2006 |
Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antiemetics; Behavior, Animal | 1994 |
Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antiemetics; Buspirone; Dose-Response Relationship, | 1994 |
The pharmacology of the emetic response to upper gastrointestinal tract stimulation in Suncus murinus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Digestive System Physiological Phenomena; Diterpene | 1996 |
Ethanol-induced emesis in the house musk shrew, Suncus murinus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetaldehyde; Alcohol Deterrents; Animals; Antiemetics; Bacl | 1997 |
The emetic and anti-emetic effects of the capsaicin analogue resiniferatoxin in Suncus murinus, the house musk shrew.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdomen; Animals; Animals, Newborn; Antiemetics; Behavior, A | 2000 |
Synthesis and dopaminergic activity of (+/-)-, (+)-, and (-)-2-dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene.
Topics: 2-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dogs; Dopamine; Humans; Naphthols; | 1976 |
8-OH-DPAT does not interfere with habituation to motion-induced emesis in cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Habituation, Psychophysiologic; Motion Sickne | 1991 |
8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Cisplatin; Dose-Response Relationship, Drug; | 1989 |