8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Urinary Bladder, Overactive in 2 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Urinary Bladder, Overactive: Symptom of overactive detrusor muscle of the URINARY BLADDER that contracts with abnormally high frequency and urgency. Overactive bladder is characterized by the frequent feeling of needing to urinate during the day, during the night, or both. URINARY INCONTINENCE may or may not be present.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we analyzed the occupancy of 5-HT1A receptors in living Sprague-Dawley rat brains by a novel candidate drug for OAB, E2110, using positron emission tomography (PET) imaging, and assessed the utility of a receptor occupancy (RO) assay to establish a pharmacodynamic index translatable between animals and humans." | 1.39 | A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder. ( Higuchi, M; Ishihara, H; Maeda, J; Nakatani, Y; Sakai, M; Suhara, T; Suzuki, M; Takenaka, O; Tokunaga, M; Yoshinaga, T; Zhang, MR, 2013) |
| "Bladder outlet obstruction was induced in adult female rats, hypertropic bladders were harvested after 6 weeks and isometric contractions of bladder strips were recorded." | 1.34 | Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats. ( Chugh, A; Malhotra, S; Mittra, S; Naruganahalli, KS, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakatani, Y | 1 |
| Suzuki, M | 1 |
| Tokunaga, M | 1 |
| Maeda, J | 1 |
| Sakai, M | 1 |
| Ishihara, H | 1 |
| Yoshinaga, T | 1 |
| Takenaka, O | 1 |
| Zhang, MR | 1 |
| Suhara, T | 1 |
| Higuchi, M | 1 |
| Mittra, S | 1 |
| Malhotra, S | 1 |
| Naruganahalli, KS | 1 |
| Chugh, A | 1 |
2 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Urinary Bladder, Overactive
| Article | Year |
|---|---|
A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Computer Simulation; Hippocam | 2013 |
Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Dose-Response Relatio | 2007 |