Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin
Page last updated: 2024-10-21

8-hydroxy-2-(di-n-propylamino)tetralin and Spinal Cord Injuries

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Spinal Cord Injuries in 18 studies

8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively

Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

Research Excerpts

ExcerptRelevanceReference
"Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement."1.48Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion. ( Anderson, MA; Anil, S; Asboth, L; Barraud, Q; Batti, L; Baud, L; Beauparlant, J; Courtine, G; Friedli, L; Kreider, J; Martinez-Gonzalez, C; Pagès, S; Pidpruzhnykova, G; Rey, E; Schneider, BL; Shkorbatova, P, 2018)
"Cervical incomplete spinal cord injuries often lead to severe and persistent impairments of sensorimotor functions and are clinically the most frequent type of spinal cord injury."1.37Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome. ( Filli, L; Schwab, ME; Weinmann, O; Zörner, B, 2011)
"After complete spinal cord transections that removed all supraspinal inputs in adult rats, combinations of serotonergic agonists and epidural electrical stimulation were able to acutely transform spinal networks from nonfunctional to highly functional and adaptive states as early as 1 week after injury."1.35Transformation of nonfunctional spinal circuits into functional states after the loss of brain input. ( Ao, Y; Courtine, G; Edgerton, VR; Gerasimenko, Y; Ichiyama, RM; Lavrov, I; Musienko, P; Roy, RR; Sofroniew, MV; Song, B; van den Brand, R; Yew, A; Zhong, H, 2009)
" Dose-response curves for (R)-8-OH-DPAT (0."1.34Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury. ( Dolber, PC; Gu, B; Reiter, JP; Thor, KB, 2007)
"After thoracic spinal cord transection, a paraplegic syndrome occurs."1.325-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat. ( Antri, M; Barthe, JY; Mouffle, C; Orsal, D, 2003)
" Dose-response curves for i."1.32Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. ( Dolber, PC; Gu, B; Olejar, KJ; Reiter, JP; Thor, KB, 2004)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (72.22)29.6817
2010's5 (27.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asboth, L1
Friedli, L1
Beauparlant, J1
Martinez-Gonzalez, C1
Anil, S1
Rey, E1
Baud, L1
Pidpruzhnykova, G1
Anderson, MA1
Shkorbatova, P1
Batti, L1
Pagès, S1
Kreider, J1
Schneider, BL1
Barraud, Q1
Courtine, G2
Sławińska, U2
Miazga, K1
Jordan, LM2
Lapointe, NP3
Ung, RV1
Rouleau, P1
Guertin, PA3
Gerasimenko, Y1
van den Brand, R1
Yew, A1
Musienko, P1
Zhong, H1
Song, B1
Ao, Y1
Ichiyama, RM1
Lavrov, I1
Roy, RR1
Sofroniew, MV1
Edgerton, VR1
Filli, L1
Zörner, B1
Weinmann, O1
Schwab, ME1
Majczyński, H1
Dai, Y1
Ganzer, PD1
Moxon, KA1
Knudsen, EB1
Shumsky, JS1
Teng, YD2
Bingaman, M1
Taveira-DaSilva, AM1
Pace, PP1
Gillis, RA1
Wrathall, JR1
Antri, M1
Mouffle, C1
Orsal, D1
Barthe, JY1
Gu, B3
Olejar, KJ1
Reiter, JP3
Thor, KB3
Dolber, PC3
Choi, H1
Liao, WL1
Newton, KM1
Onario, RC1
King, AM1
Desilets, FC1
Woodard, EJ1
Eichler, ME1
Frontera, WR1
Sabharwal, S1
Tai, C1
Miscik, CL1
Ungerer, TD1
Roppolo, JR1
de Groat, WC2
Zimmer, MB1
Goshgarian, HG1
Landry, ES1
Rouillard, C1
Levesque, D1
Hedlund, PB1
Chang, HY1
Cheng, CL1
Chen, JJ1
Zhang, X1
Fraser, MO1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study on Preliminary Safety and Efficacy of the ARC Therapy Using the ARC-IM Lumbar System to Support Mobility in People With Chronic Spinal Cord Injury[NCT05942339]8 participants (Anticipated)Interventional2023-08-31Not yet recruiting
STIMO-PARKINSON: Study on Feasibility of Targeted Epidural Spinal Stimulation (TESS) to Improve Mobility in Patients With Parkinson's Disease[NCT04956770]2 participants (Actual)Interventional2021-06-14Active, not recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT04994886]8 participants (Anticipated)Interventional2021-06-08Recruiting
Restoring Hemodynamic Stability Using Targeted Epidural Spinal Stimulation Following Spinal Cord Injury[NCT05044923]8 participants (Anticipated)Interventional2021-12-31Recruiting
Epidural Electrical Stimulation to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury[NCT05111093]20 participants (Anticipated)Interventional2021-11-29Recruiting
Priming With High-Frequency Trans-spinal Stimulation to Augment Locomotor Benefits in Spinal Cord Injury[NCT04807764]45 participants (Anticipated)Interventional2021-08-01Recruiting
Tri-therapy (SPINALON)-Elicited Spinal Locomotor Network Activation: Phase I-IIa Clinical Trial in Patients With Chronic Spinal Cord Injury[NCT01484184]Phase 1/Phase 250 participants (Actual)Interventional2013-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

18 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Spinal Cord Injuries

ArticleYear
Cortico-reticulo-spinal circuit reorganization enables functional recovery after severe spinal cord contusion.
    Nature neuroscience, 2018, Volume: 21, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Channelrhodopsins; Disease Models, Animal; F

2018
5-HT₂ and 5-HT₇ receptor agonists facilitate plantar stepping in chronic spinal rats through actions on different populations of spinal neurons.
    Frontiers in neural circuits, 2014, Volume: 8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Electromyography; Female; Hin

2014
Tail pinching-induced hindlimb movements are suppressed by clonidine in spinal cord injured mice.
    Behavioral neuroscience, 2008, Volume: 122, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Behavior, Animal; Clonidine; Dose-Respo

2008
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Transformation of nonfunctional spinal circuits into functional states after the loss of brain input.
    Nature neuroscience, 2009, Volume: 12, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Biomechanical Phenomena; Brai

2009
Motor deficits and recovery in rats with unilateral spinal cord hemisection mimic the Brown-Sequard syndrome.
    Brain : a journal of neurology, 2011, Volume: 134, Issue:Pt 8

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Apomorphine; Brown-Sequard Syndrome; Clonidine; Dis

2011
The upright posture improves plantar stepping and alters responses to serotonergic drugs in spinal rats.
    The Journal of physiology, 2012, Apr-01, Volume: 590, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Female; Foot; Hindlimb; Locomotion; Neurons, Affere

2012
Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury.
    Experimental neurology, 2013, Volume: 241

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Brain Mapping; Cerebral Corte

2013
Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, May-15, Volume: 23, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Buspirone; Female; Piperazines; Rat

2003
5-HT1A receptors are involved in short- and long-term processes responsible for 5-HT-induced locomotor function recovery in chronic spinal rat.
    The European journal of neuroscience, 2003, Volume: 18, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Biomechanical Phenomena; Electrom

2003
Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acrylamides; Animals; Blood Pressure; Carotid Arteries; Cats

2004
Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, May-04, Volume: 25, Issue:18

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Buspirone;

2005
Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-HT1A receptors.
    Experimental neurology, 2006, Volume: 199, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Chronic Disease; Disease Models, Animal; Fema

2006
Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury.
    The journal of spinal cord medicine, 2006, Volume: 29, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Afferent Pathways; Animals; Female; Functional Laterality; M

2006
Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice.
    The European journal of neuroscience, 2006, Volume: 24, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Efferent Pathways; Locomoti

2006
Serotonergic drugs and spinal cord transections indicate that different spinal circuits are involved in external urethral sphincter activity in rats.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electric Stimulation; Electromyography; Female; Hyd

2007
Activation of the external urethral sphincter central pattern generator by a 5-HT(1A) receptor agonist in rats with chronic spinal cord injury.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Chronic Disease; Dose-Response Relationship, Drug;

2007
Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury.
    The Journal of urology, 2007, Volume: 177, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetic Acid; Acrylamides; Animals; Cats; Female; Indoles; Ne

2007
Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice.
    Journal of neurophysiology, 2008, Volume: 100, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Benzazepine

2008