8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Serotonin Syndrome in 15 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emerging evidence from case reports suggests that fentanyl may precipitate potentially life-threatening serotonin syndrome in patients taking serotonergic drugs." | 7.83 | Effects of fentanyl on serotonin syndrome-like behaviors in rats. ( Kaminaga, S; Kawano, T; Kitamura, S; Locatelli, FM; Tateiwa, H; Yamanaka, D; Yokoyama, M, 2016) |
| "8-OH-DPAT-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with WAY 100635, a selective 5-HT1A antagonist (n = 8)." | 5.42 | A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats. ( Eguchi, S; Iwata, H; Kadono, T; Kaminaga, S; Kawano, T; Takahashi, T; Yamanaka, D; Yokoyama, M, 2015) |
| "Emerging evidence from case reports suggests that fentanyl may precipitate potentially life-threatening serotonin syndrome in patients taking serotonergic drugs." | 3.83 | Effects of fentanyl on serotonin syndrome-like behaviors in rats. ( Kaminaga, S; Kawano, T; Kitamura, S; Locatelli, FM; Tateiwa, H; Yamanaka, D; Yokoyama, M, 2016) |
| " The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only." | 3.74 | Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. ( Fox, MA; French, HT; Huang, SJ; Jensen, CL; Murphy, DL; Stein, AR; Tolliver, TJ, 2008) |
| "8-OH-DPAT-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with WAY 100635, a selective 5-HT1A antagonist (n = 8)." | 1.42 | A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats. ( Eguchi, S; Iwata, H; Kadono, T; Kaminaga, S; Kawano, T; Takahashi, T; Yamanaka, D; Yokoyama, M, 2015) |
| "Rats treated with haloperidol at a dose of 1 mg/kg twice a day for 2 weeks displayed VCMs with twitching of facial musculature that increased in a time dependent manner as the treatment continued to 5 weeks." | 1.34 | Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats. ( Haleem, DJ; Haleem, MA; Samad, N, 2007) |
| "Lesopitron inhibits haloperidol-induced catalepsy that is the consequence of its action on 5-HT1A autoreceptors." | 1.32 | Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors. ( Camarasa, J; Escubedo, E; Farré, A; Fisas, MA, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tran, HQ | 1 |
| Shin, EJ | 1 |
| Hoai Nguyen, BC | 1 |
| Phan, DH | 1 |
| Kang, MJ | 1 |
| Jang, CG | 1 |
| Jeong, JH | 1 |
| Nah, SY | 1 |
| Mouri, A | 1 |
| Saito, K | 1 |
| Nabeshima, T | 1 |
| Kim, HC | 1 |
| Chioca, LR | 1 |
| Ferro, MM | 1 |
| Baretta, IP | 1 |
| Oliveira, SM | 1 |
| Silva, CR | 1 |
| Ferreira, J | 1 |
| Losso, EM | 1 |
| Andreatini, R | 1 |
| Kawano, T | 2 |
| Takahashi, T | 1 |
| Kaminaga, S | 2 |
| Kadono, T | 1 |
| Yamanaka, D | 2 |
| Iwata, H | 1 |
| Eguchi, S | 1 |
| Yokoyama, M | 2 |
| Kitamura, S | 1 |
| Tateiwa, H | 1 |
| Locatelli, FM | 1 |
| Fox, MA | 2 |
| Jensen, CL | 2 |
| French, HT | 1 |
| Stein, AR | 1 |
| Huang, SJ | 1 |
| Tolliver, TJ | 1 |
| Murphy, DL | 2 |
| Jabeen, B | 1 |
| Haleem, DJ | 4 |
| Batool, F | 1 |
| Fisas, MA | 1 |
| Farré, A | 1 |
| Camarasa, J | 1 |
| Escubedo, E | 1 |
| Bert, B | 1 |
| Fink, H | 1 |
| Hörtnagl, H | 1 |
| Veh, RW | 1 |
| Davies, B | 1 |
| Theuring, F | 1 |
| Kusserow, H | 1 |
| Inam, QU | 1 |
| Haleem, MA | 2 |
| Samad, N | 1 |
| Gallagher, PS | 1 |
| Darmani, NA | 2 |
| Zhao, W | 1 |
| Ahmad, B | 1 |
| Borsini, F | 1 |
| Brambilla, A | 1 |
| Cesana, R | 1 |
| Grippa, N | 1 |
15 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Serotonin Syndrome
| Article | Year |
|---|---|
5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Hypothalamus; Male; Mice; Mice, I | 2019 |
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Inhalation; Animals; Anti-Anxiety Agents; Be | 2013 |
A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzodiazepines; Dexmedetomidine; Hypnotics and Sed | 2015 |
Effects of fentanyl on serotonin syndrome-like behaviors in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Fentanyl; Male; Motor Activity; Rats; Rats, Sprague | 2016 |
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Catech | 2008 |
Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: implications for sugar-induced obesity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Brain; Dietary Sucro | 2008 |
Serotonin(1A) receptor agonism in the expression of behavioral dopaminergic supersensitivity in subchronic haloperidol treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basal Ganglia Diseases; Behavior, Animal; Brain; Di | 2008 |
Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Catalepsy; Central Nervous System; Central Nervous | 2004 |
Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Dentate Gyrus; Dose-Response Relat | 2006 |
Effects of long term consumption of sugar as part of meal on serotonin 1-a receptor dependent responses.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Brain; Dietary Sucrose; Eatin | 2006 |
Reversal of haloperidol-induced tardive vacuous chewing movements and supersensitive somatodendritic serotonergic response by buspirone in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Buspirone; Chromatography, Hi | 2007 |
Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Dose-Respons | 2007 |
Production of serotonin syndrome by 8-OH DPAT in Cryptotis parva.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Dose-Response Relation | 1998 |
Long-term sequential determination of behavioral ontogeny of 5-HT1A and 5-HT2 receptor functions in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Body Temperature; Female; Head Moveme | 1999 |
Lack of interaction between flibanserin and antidepressants in inducing serotonergic syndrome in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepressive Agents, Secon | 2001 |