Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin
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8-hydroxy-2-(di-n-propylamino)tetralin and Pregnancy

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Pregnancy in 37 studies

8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Recurrent apneas are important causes of hospitalization and morbidity in newborns."7.79Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat. ( Bairam, A; Caravagna, C; Fournier, S; Gulemetova, R; Julien, C; Kinkead, R; Soliz, J; Steele, S, 2013)
"Recurrent apneas are important causes of hospitalization and morbidity in newborns."3.79Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat. ( Bairam, A; Caravagna, C; Fournier, S; Gulemetova, R; Julien, C; Kinkead, R; Soliz, J; Steele, S, 2013)
"The present work was aimed at a comparative investigation of the effects of chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT (0."1.38[Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions]. ( Fedotova, IuO; Ordian, NÉ; Pivina, SG, 2012)
"Paroxetine treatment desensitized 5-HT(1A) receptor-mediated increases in oxytocin, ACTH and corticosterone to a comparable extent in all offspring and reduced the E(max) for ACTH only in prenatal cocaine-exposed offspring."1.33Paroxetine is effective in desensitizing 5-HT1A receptor function in adult offspring exposed prenatally to cocaine. ( Battaglia, G; Carrasco, GA; Chen, Z; Muma, NA; Shankaran, M; Sripathirathan, K; Tetzlaff, J; Van De Kar, LD, 2005)
" Neither the prolactin nor the ACTH response was augmented significantly in the animals exposed prenatally to either nicotine dosage regimen, although there was a strong trend for the augmentation to occur in the low-dose nicotine exposed animals."1.29Exposure to threshold doses of nicotine in utero: III. Augmentation of the prolactin and ACTH response to 8-OH DPAT by desipramine treatment is compromised in adult male offspring. ( Acosta, S; Au, D; Lutchmansingh, P; McCracken, JT; McGeoy, S; Poland, RE; Que, M, 1996)
" We performed acute dose-response and time course behavioral studies in 1-day-old rats with the putative selective agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (5-HT1A), 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H-indole (RU 24969) (5-HT1B), and (+-)1-(2,5-dimethoxy-4-iodo-phenyl aminopropane)-2 (DOI) (5-HT2/1C)."1.28Serotonin receptor ontogeny: effects of agonists in 1-day-old rats. ( Pranzatelli, MR, 1992)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.70)18.7374
1990's16 (43.24)18.2507
2000's13 (35.14)29.6817
2010's7 (18.92)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, CC1
Lin, HC1
Chan, YH1
Gean, PW1
Yang, YK1
Chen, PS1
Miyazaki, I1
Asanuma, M1
Murakami, S1
Takeshima, M1
Torigoe, N1
Kitamura, Y1
Miyoshi, K1
Fedotova, IuO2
Pivina, SG2
Akulova, VK1
Ordian, NÉ2
Kiryanova, V1
Smith, VM1
Dyck, RH1
Antle, MC1
Cordeaux, Y1
Pasupathy, D1
Bacon, J1
Charnock-Jones, DS1
Smith, GC1
Lovic, V1
Belay, H1
Walker, CD1
Burton, CL1
Meaney, MJ1
Sokolowski, M1
Fleming, AS1
Fournier, S2
Steele, S1
Julien, C1
Gulemetova, R1
Caravagna, C1
Soliz, J1
Bairam, A1
Kinkead, R1
Cannizzaro, C1
Martire, M1
Cannizzaro, E1
Monastero, R1
Gagliano, M1
Mineo, A1
Provenzano, G1
Lai, M1
McCormick, JA1
Chapman, KE1
Kelly, PA1
Seckl, JR1
Yau, JL1
Arborelius, L1
Hawks, BW1
Owens, MJ1
Plotsky, PM1
Nemeroff, CB1
Lee, HJ1
Ban, JY1
Cho, SO1
Seong, YH1
Chen, Z1
Tetzlaff, J1
Sripathirathan, K1
Carrasco, GA1
Shankaran, M1
Van De Kar, LD2
Muma, NA1
Battaglia, G3
Griffin, WC1
Skinner, HD1
Birkle, DL1
Hofmann, CE1
Patyk, IA1
Weinberg, J1
Sodero, AO1
Orsingher, OA1
Ramírez, OA1
Vicentic, A2
Francis, D1
Moffett, M1
Lakatos, A1
Rogge, G1
Hubert, GW1
Harley, J1
Kuhar, MJ1
Maciag, D1
Coppinger, D1
Paul, IA1
Riad, M1
Emerit, MB1
Hamon, M1
Pranzatelli, MR2
Durkin, MM1
Barkai, AI1
Cabrera, TM1
Klint, T1
Andersson, G1
Blatt, GJ1
Chen, JC1
Rosene, DL1
Volicer, L1
Galler, JR1
Johansson-Wallsten, CE1
Berg, M1
Meyerson, BJ1
Poland, RE1
Lutchmansingh, P1
Au, D1
McGeoy, S1
Que, M1
Acosta, S1
McCracken, JT1
Kim, JA1
Gillespie, RA1
Druse, MJ1
Maswood, N1
Uphouse, L1
Watanabe, M1
Kodama, Y1
Hagino, Y1
Nonaka, R1
Kaichi, Y1
Cabrera-Vera, TM1
Garcia, F1
Pinto, W1
Jahn, GA1
Kalia, V1
Hole, D1
Wilson, CA1
Deis, RP1
Shirayama, Y1
Muneoka, KT1
Takigawa, M1
Minabe, Y1
Pletnikov, MV1
Rubin, SA1
Vogel, MW1
Moran, TH1
Carbone, KM1
Mokler, DJ1
Sullivan, SA1
Winterson, BJ1
Bell, J1
Zhang, XN1
Whitaker-Azmitia, PM1
de Rooy, EC1
Coscina, DV1
Weiss, S1
Sebben, M1
Kemp, DE1
Bockaert, J1

Other Studies

37 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Pregnancy

ArticleYear
5-HT1A-receptor agonist modified amygdala activity and amygdala-associated social behavior in a valproate-induced rat autism model.
    The international journal of neuropsychopharmacology, 2013, Volume: 16, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Autistic Disorder; Behavior, Animal; Cina

2013
Targeting 5-HT(1A) receptors in astrocytes to protect dopaminergic neurons in Parkinsonian models.
    Neurobiology of disease, 2013, Volume: 59

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Agents; Animals; Astrocytes; Brain; Buspirone; Ce

2013
[Effects of 8-OH-DPAT and m-CPP on depression-like behavior in prenatally stressed ovariectomized rats treated with low dose of 17beta-estradiol].
    Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Depression; Estradiol; Estrogens;

2014
Circadian behavior of adult mice exposed to stress and fluoxetine during development.
    Psychopharmacology, 2017, Volume: 234, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Circadian Rhythm; Female; Fluoxet

2017
Characterization of serotonin receptors in pregnant human myometrium.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Breech Presentation; Cesarean Section; Delivery, Obstetric;

2009
[Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Estrogens; Female; Male;

2012
Early postnatal experience and DRD2 genotype affect dopamine receptor expression in the rat ventral striatum.
    Behavioural brain research, 2013, Jan-15, Volume: 237

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Basal Gangl

2013
Gestational stress promotes pathological apneas and sex-specific disruption of respiratory control development in newborn rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-09, Volume: 33, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Apnea; Corticosterone; Female; Hy

2013
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2003, Volume: 13, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diaze

2003
Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture.
    Neuroscience, 2003, Volume: 118, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Amitriptyline; Animals; Animals

2003
Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation.
    Psychopharmacology, 2004, Volume: 176, Issue:3-4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding Sites; Citalopram; Dose-Re

2004
Stimulation of 5-HT1A receptor with 8-OH-DPAT inhibits hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells.
    Pharmacological research, 2005, Volume: 51, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Do

2005
Paroxetine is effective in desensitizing 5-HT1A receptor function in adult offspring exposed prenatally to cocaine.
    Psychopharmacology, 2005, Volume: 180, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Cocaine; Corticosteron

2005
Prenatal stress influences 8-OH-DPAT modulated startle responding and [3H]-8-OH-DPAT binding in rats.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Binding, Competitive; Dose-Re

2005
Prenatal ethanol exposure: sex differences in anxiety and anxiolytic response to a 5-HT1A agonist.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Feeding Behavior; Female; Humans; Male; Pr

2005
Altered serotonergic function of dorsal raphe nucleus in perinatally protein-deprived rats: effects of fluoxetine administration.
    European journal of pharmacology, 2006, Feb-27, Volume: 532, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Dose-Response Relationship, Drug

2006
Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain.
    Neuroscience, 2006, Jun-19, Volume: 140, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Age Factors; Analysis of Varian

2006
Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Brain research, 2006, Dec-13, Volume: 1125, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Analysis of Variance; Animals; Animals, Newborn

2006
Neurotrophic effects of ipsapirone and other 5-HT1A receptor agonists on septal cholinergic neurons in culture.
    Brain research. Developmental brain research, 1994, Oct-14, Volume: 82, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Autoradiography; Brain; Cell Divisio

1994
Quantitative autoradiography of 5-hydroxytryptamine1A binding sites in rats with chronic neonatal 5,7-dihydroxytryptamine lesions.
    Brain research. Developmental brain research, 1994, Jul-15, Volume: 80, Issue:1-2

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Autoradi

1994
Potentiation of 5-HT1A receptor-mediated neuroendocrine responses in male but not female rat progeny after prenatal cocaine: evidence for gender differences.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Cocaine; Corticosteron

1994
Ultrasound vocalization is not related to corticosterone response in isolated rat pups.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety; Buspirone; Corticosteron

1994
Prenatal protein malnutrition effects on the serotonergic system in the hippocampal formation: an immunocytochemical, ligand binding, and neurochemical study.
    Brain research bulletin, 1994, Volume: 34, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Chromatography, High Pressure Liquid; Citalopram; F

1994
The effects of long-term treatment with the 5-HT1A receptor agonist 8-OH-DPAT and the 5-HT2/1C receptor agonist DOI in the neonatal rat.
    European journal of pharmacology, 1993, Oct-19, Volume: 243, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Animals, Newborn; Dose-Response Relat

1993
Exposure to threshold doses of nicotine in utero: III. Augmentation of the prolactin and ACTH response to 8-OH DPAT by desipramine treatment is compromised in adult male offspring.
    Neurotoxicology, 1996,Summer, Volume: 17, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Adrenocorticotropic Hormone; A

1996
Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring.
    Alcoholism, clinical and experimental research, 1997, Volume: 21, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Autoradiography; Brain; Brain Map

1997
Modulation of the behavioral effects of 8-OH-DPAT by estrogen and DOI.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Body Temperature; E

1997
Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly.
    Brain research, 1998, Mar-23, Volume: 787, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkylating Agents; Amitriptyline; Animals; Antidepressive Ag

1998
Prenatal cocaine exposure produces long-term impairments in brain serotonin function in rat offspring.
    Annals of the New York Academy of Sciences, 1998, Jun-21, Volume: 846

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Brain; Cocaine; Female

1998
Receptors and neurotransmitters involved in the dual modulation of prolactin release by the serotoninergic system in pregnant and lactating rats.
    Journal of reproduction and fertility, 1999, Volume: 116, Issue:2

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Adrenergi

1999
Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.
    Neuroreport, 2001, Dec-04, Volume: 12, Issue:17

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Aging; Animals; Animals, Newborn; Antihypertensiv

2001
Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments.
    Brain research, 2002, Jul-19, Volume: 944, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animal Diseases; Animals; Animals, Newborn; Borna Disease; B

2002
Behaviors induced by 5-hydroxytryptophan in neonatal, preweaning, postweaning, and adult Sprague-Dawley rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 42, Issue:3

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Animals,

1992
Serotonin receptor ontogeny: effects of agonists in 1-day-old rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Animals, Newborn; Female; Indo

1992
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
    Brain research, 1992, Feb-07, Volume: 571, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem

1992
Effects of systemic 8-OH-DPAT on the feeding induced by hypothalamic NE infusion.
    Pharmacology, biochemistry, and behavior, 1990, Volume: 36, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cricetinae; Drug Interactions; Eating; Female; Hypo

1990
Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons.
    European journal of pharmacology, 1986, Jan-21, Volume: 120, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Brain; Cerebral Cortex; Corpus S

1986