8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Panic Disorder in 6 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Panic Disorder: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The escape behaviour induced in rats by injecting D,L-homocysteic acid (DHL) into the dorsal periaqueductal grey area (DPAG) was used as an animal model of panic attacks to investigate the effect of imipramine, a drug used for the treatment of panic disorder, on the sensitivity of 5-HT1A receptors in the DPAG." | 3.69 | Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats. ( Marsden, CA; Mongeau, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roncon, CM | 1 |
| Yamashita, PSM | 1 |
| Frias, AT | 1 |
| Audi, EA | 1 |
| Graeff, FG | 1 |
| Coimbra, NC | 1 |
| Zangrossi, H | 4 |
| Strauss, CV | 1 |
| Vicente, MA | 1 |
| Nascimento, JO | 1 |
| Kikuchi, LS | 1 |
| de Bortoli, VC | 1 |
| Viana, MB | 2 |
| Miguel, TL | 1 |
| Pobbe, RL | 2 |
| Spiacci Junior, A | 1 |
| Zangrossi Junior, H | 1 |
| Sena, LM | 1 |
| Bueno, C | 1 |
| Andrade, TG | 1 |
| Mongeau, R | 1 |
| Marsden, CA | 1 |
6 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Panic Disorder
| Article | Year |
|---|---|
μ-Opioid and 5-HT1A receptors in the dorsomedial hypothalamus interact for the regulation of panic-related defensive responses.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly | 2017 |
Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Dark Adapta | 2013 |
Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Avoidance Learning; Disease M | 2014 |
Dorsal raphe nucleus regulation of a panic-like defensive behavior evoked by chemical stimulation of the rat dorsal periaqueductal gray matter.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Escape Reaction; Homocystei | 2010 |
The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learnin | 2003 |
Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Tricyc | 1997 |