8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Obsessive-Compulsive Disorder in 17 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be effective in treating obsessive-compulsive disorder." | 8.31 | Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. ( Botvinnik, A; Lerer, B; Lifschytz, T; Lotan, A; Saban, M; Salama, A; Shahar, O; Singh, S; Wolf, G; Yakobi, C, 2023) |
| " In the present study, we examined the effect of perospirone on marble-burying behavior, which has been considered an animal model of obsessive-compulsive disorder (OCD), compared with the effects of other antipsychotics such as haloperidol and risperidone." | 7.73 | Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder. ( Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R, 2005) |
| " Chronic administration of AKBA at 50 mg/kg and 100 mg/kg p." | 5.91 | Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations. ( Chhabra, S; Khan, Z; Mehan, S; Sethi, P, 2023) |
| "Preliminary clinical findings, supported by preclinical studies employing behavioral paradigms such as marble burying, suggest that psilocybin may be effective in treating obsessive-compulsive disorder." | 4.31 | Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. ( Botvinnik, A; Lerer, B; Lifschytz, T; Lotan, A; Saban, M; Salama, A; Shahar, O; Singh, S; Wolf, G; Yakobi, C, 2023) |
| " In the present study, we examined the effect of perospirone on marble-burying behavior, which has been considered an animal model of obsessive-compulsive disorder (OCD), compared with the effects of other antipsychotics such as haloperidol and risperidone." | 3.73 | Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder. ( Egashira, N; Fujiwara, M; Harada, S; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Okuno, R, 2005) |
| " Chronic administration of AKBA at 50 mg/kg and 100 mg/kg p." | 1.91 | Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations. ( Chhabra, S; Khan, Z; Mehan, S; Sethi, P, 2023) |
| "Melatonin has beneficial effects on various illnesses, including Alzheimer's, Parkinson's, and depression, indicating its potential efficacy in treating OCD." | 1.91 | Melatonin-mediated IGF-1/GLP-1 activation in experimental OCD rats: Evidence from CSF, blood plasma, brain and in-silico investigations. ( Giri, A; Gupta, GD; Khan, Z; Mehan, S; Narula, AS, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Singh, S | 1 |
| Botvinnik, A | 1 |
| Shahar, O | 1 |
| Wolf, G | 1 |
| Yakobi, C | 1 |
| Saban, M | 1 |
| Salama, A | 1 |
| Lotan, A | 1 |
| Lerer, B | 1 |
| Lifschytz, T | 1 |
| Sethi, P | 1 |
| Mehan, S | 2 |
| Khan, Z | 2 |
| Chhabra, S | 1 |
| Giri, A | 1 |
| Gupta, GD | 1 |
| Narula, AS | 1 |
| Janikova, M | 1 |
| Mainerova, K | 1 |
| Vojtechova, I | 1 |
| Petrasek, T | 1 |
| Svoboda, J | 1 |
| Stuchlik, A | 1 |
| Tucci, MC | 1 |
| Dvorkin-Gheva, A | 2 |
| Johnson, E | 1 |
| Cheon, P | 1 |
| Taji, L | 1 |
| Agarwal, A | 1 |
| Foster, J | 1 |
| Szechtman, H | 2 |
| S N, U | 1 |
| J M, V | 1 |
| N S, J | 1 |
| P V, D | 1 |
| Albelda, N | 1 |
| Joel, D | 1 |
| Shanahan, NA | 1 |
| Velez, LP | 1 |
| Masten, VL | 1 |
| Dulawa, SC | 1 |
| Alkhatib, AH | 1 |
| Olvera-Hernández, S | 1 |
| Chavira, R | 1 |
| Fernández-Guasti, A | 4 |
| Ulloa, RE | 2 |
| Nicolini, H | 2 |
| van Kuyck, K | 1 |
| Demeulemeester, H | 2 |
| Feys, H | 2 |
| De Weerdt, W | 2 |
| Dewil, M | 1 |
| Tousseyn, T | 1 |
| De Sutter, P | 2 |
| Gybels, J | 2 |
| Bogaerts, K | 1 |
| Dom, R | 1 |
| Nuttin, B | 2 |
| Matsushita, M | 1 |
| Egashira, N | 1 |
| Harada, S | 1 |
| Okuno, R | 1 |
| Mishima, K | 1 |
| Iwasaki, K | 1 |
| Nishimura, R | 1 |
| Fujiwara, M | 1 |
| Agrati, D | 1 |
| Reyes, R | 1 |
| Ferreira, A | 1 |
| Goris, I | 1 |
| Zwaenepoel, I | 1 |
| Plets, C | 1 |
| Yadin, E | 1 |
| Friedman, E | 1 |
| Bridger, WH | 1 |
1 review available for 8-hydroxy-2-(di-n-propylamino)tetralin and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Deep Brain Stimulation; Disease Models, Animal; Dop | 2012 |
16 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Escitalopram; Hallucinogens; Male; Mice; | 2023 |
Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Fluvoxamine; NF-E2-Related Factor | 2023 |
Melatonin-mediated IGF-1/GLP-1 activation in experimental OCD rats: Evidence from CSF, blood plasma, brain and in-silico investigations.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Glucagon-Like Peptide 1; Insulin-Like Growth | 2023 |
Memantine and Riluzole Exacerbate, Rather Than Ameliorate Behavioral Deficits Induced by 8-OH-DPAT Sensitization in a Spatial Task.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Disease Models, Animal; Male; Mem | 2021 |
Performance of compulsive behavior in rats is not a unitary phenomenon - validation of separate functional components in compulsive checking behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Compulsive Behavior; Disease Models, Animal; Male; | 2014 |
Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Dehydroepia | 2009 |
Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Adrenergic beta-Antagonists; Adrenergi | 2011 |
Quinpirole and 8-OH-DPAT induce compulsive checking behavior in male rats by acting on different functional parts of an OCD neurocircuit.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Compulsive Behavior; Disea | 2013 |
Sex- and endocrine-stage-differences in middle-aged rats in an animal model of OCD.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Analysis of Variance; Animals; Disease Models, | 2013 |
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Antidepressive Agents, Tricyclic; Clomiprami | 2003 |
Effects of electrical stimulation or lesion in nucleus accumbens on the behaviour of rats in a T-maze after administration of 8-OH-DPAT or vehicle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Disease Models, Animal; Electric | 2003 |
Sex differences on spontaneous alternation in prepubertal rats: implications for an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Disease Models, Animal; Fe | 2004 |
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Disease Mod | 2005 |
Ovarian steroids counteract serotonergic drugs actions in an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Estradiol; Estrous Cycle; Female; Fluoxetine; Obses | 2006 |
Effect of the serotonin agonist 8-OH-DPAT on the sensorimotor system of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Disease Models, Animal; Male; Obsessive-Compulsive | 2001 |
Spontaneous alternation behavior: an animal model for obsessive-compulsive disorder?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Disease Models, Animal; Fluoxetin | 1991 |