8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Neuroblastoma in 6 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Carbachol stimulated the rate of inositol phospholipid breakdown in IMR-32 and SK-N-MC human neuroblastoma cells with an EC50 value of about 50 microM in both cases." | 7.68 | Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells. ( Ahlgren, PC; Fowler, CJ; O'Neill, C, 1991) |
| " Carbachol stimulated the rate of inositol phospholipid breakdown in IMR-32 and SK-N-MC human neuroblastoma cells with an EC50 value of about 50 microM in both cases." | 3.68 | Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells. ( Ahlgren, PC; Fowler, CJ; O'Neill, C, 1991) |
| "Serotonin (5-HT) induced a transient rise of the cyclic GMP level in neuroblastoma X glioma hybrid cells, half-maximally at 1 microM 5-HT." | 3.67 | Serotonin raises the cyclic GMP level in a neuronal cell line via 5-HT3 receptors. ( Hamprecht, B; Reiser, G, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cappelli, A | 1 |
| Anzini, M | 1 |
| Vomero, S | 1 |
| Mennuni, L | 1 |
| Makovec, F | 1 |
| Doucet, E | 1 |
| Hamon, M | 1 |
| Bruni, G | 1 |
| Romeo, MR | 1 |
| Menziani, MC | 1 |
| De Benedetti, PG | 1 |
| Langer, T | 1 |
| Mehta, M | 1 |
| Ahmed, Z | 1 |
| Fernando, SS | 1 |
| Cano-Sanchez, P | 1 |
| Adayev, T | 1 |
| Ziemnicka, D | 1 |
| Wieraszko, A | 1 |
| Banerjee, P | 2 |
| Charest, A | 1 |
| Wainer, BH | 1 |
| Albert, PR | 1 |
| Berry-Kravis, E | 1 |
| Bonafede-Chhabra, D | 1 |
| Dawson, G | 1 |
| Fowler, CJ | 1 |
| Ahlgren, PC | 1 |
| O'Neill, C | 1 |
| Reiser, G | 1 |
| Hamprecht, B | 1 |
6 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Neuroblastoma
| Article | Year |
|---|---|
Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
Topics: Animals; Benzene; Binding Sites; Glioma; Guanidine; Mice; Models, Molecular; Molecular Structure; Ne | 1998 |
Plasticity of 5-HT 1A receptor-mediated signaling during early postnatal brain development.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Bromodeoxyuridine; Cell Line, Tum | 2007 |
Cloning and differentiation-induced expression of a murine serotonin1A receptor in a septal cell line.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Base Sequence; Cell Differentiation; Cloning, Molec | 1993 |
Heterologous expression of the serotonin 5-HT1A receptor in neural and non-neural cell lines.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Cell Line; CHO Cells; Cricetinae | 1993 |
Antagonism by 8-hydroxy-2(di-n-propylamino)tetraline and other serotonin agonists of muscarinic M1-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Buspirone; Carbachol; Hippocampus; Humans; Inositol Phosphat | 1991 |
Serotonin raises the cyclic GMP level in a neuronal cell line via 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Line; Cyclic AMP; Cyclic GMP; Glioma; Mice; Ne | 1989 |