8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Nerve Degeneration in 7 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " MPTP-treated mice maintained at 4 degrees C demonstrated (1) a greater hypothermic response, (2) a significant reduction in striatal DA content and tyrosine hydroxylase (TH) activity, and (3) significantly greater striatal 1-methyl-4-phenylpyridinium (MPP+) levels, as compared to mice dosed with MPTP at room temperature." | 1.30 | Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice. ( Albers, DS; Moy, LY; Sonsalla, PK, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Q | 1 |
| Wang, S | 1 |
| Zhang, L | 1 |
| Zhang, H | 1 |
| Qiao, H | 1 |
| Niu, X | 1 |
| Liu, J | 1 |
| Alter, SP | 1 |
| Stout, KA | 1 |
| Lohr, KM | 1 |
| Taylor, TN | 1 |
| Shepherd, KR | 1 |
| Wang, M | 1 |
| Guillot, TS | 1 |
| Miller, GW | 1 |
| Gobbi, M | 1 |
| Regondi, MC | 1 |
| Pompeiano, M | 1 |
| Palacios, JM | 1 |
| Mennini, T | 1 |
| Laporte, AM | 1 |
| Fattaccini, CM | 1 |
| Lombard, MC | 1 |
| Chauveau, J | 1 |
| Hamon, M | 2 |
| Moy, LY | 1 |
| Albers, DS | 1 |
| Sonsalla, PK | 1 |
| Liang, SL | 1 |
| Pan, JT | 1 |
| Verge, D | 1 |
| Daval, G | 1 |
| Patey, A | 1 |
| Gozlan, H | 1 |
| el Mestikawy, S | 1 |
7 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Nerve Degeneration
| Article | Year |
|---|---|
Decreased response of interneurons in the medial prefrontal cortex to 5-HT₁A receptor activation in the rat 6-hydroxydopamine Parkinson model.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Dose-Response Relationship, Drug | 2014 |
Reduced vesicular monoamine transport disrupts serotonin signaling but does not cause serotonergic degeneration.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Corpus Striatum; Mice; Mice, Transgen | 2016 |
Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Ci | 1994 |
Effects of dorsal rhizotomy and selective lesion of serotonergic and noradrenergic systems on 5-HT1A, 5-HT1B, and 5-HT3 receptors in the rat spinal cord.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Benzamide | 1995 |
Lowering ambient or core body temperature elevates striatal MPP+ levels and enhances toxicity to dopamine neurons in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; 8-Hydroxy-2-(di-n-propyla | 1998 |
An endogenous serotonergic rhythm acting on 5-HT(2A) receptors may be involved in the diurnal changes in tuberoinfundibular dopaminergic neuronal activity and prolactin secretion in female rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amp | 2000 |
Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Hippocamp | 1985 |