8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Hypothermia, Accidental in 84 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)(1A)-receptor full agonist, -induced hypothermia was examined in rats." | 7.72 | Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats. ( Araki, H; Gomita, Y; Kitamura, Y; Shibata, K; Tanizaki, Y, 2003) |
| "Flesinoxan is a high affinity and selective 5-hydroxytryptamine1A (5-HT1A) ligand which, unlike the 5-HT1A agonists of the azapirone class, does not generate 1-(2-pyrimidinyl)piperazine, an alpha 2-adrenoreceptor antagonist." | 5.29 | Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. ( Blier, P; de Montigny, C; Dennis, T; Hadrava, V; Ortemann, C, 1995) |
| "Based on our previous results and the present data, it should be presumed that presynaptic 5-HT(1A) autoreceptor mechanisms may be involved in the inhibitory effect of spinosin on 8-OH-DPAT-induced hypothermia and also in the potentiating effect of spinosin on pentobarbital-induced LORR in mice." | 3.78 | Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor. ( Wang, LE; Yin, YQ; Zhang, XQ; Zhang, YH, 2012) |
| " The 5-HT1A antagonist WAY 100635 decreased 5-HTP-induced hypothermia in SERT+/+ and +/- mice with no effect in SERT-/- mice, whereas the 5-HT7 antagonist SB 269970 decreased this exaggerated response in SERT-/- mice only." | 3.74 | Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. ( Fox, MA; French, HT; Huang, SJ; Jensen, CL; Murphy, DL; Stein, AR; Tolliver, TJ, 2008) |
| "The effects of imipramine on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), the 5-hydroxytryptamine (5-HT)(1A)-receptor full agonist, -induced hypothermia was examined in rats." | 3.72 | Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats. ( Araki, H; Gomita, Y; Kitamura, Y; Shibata, K; Tanizaki, Y, 2003) |
| ") antagonized the hypothermia induced by the D2/D1 receptor agonist, apomorphine (16 mg/kg, s." | 3.70 | Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms. ( Baker, GB; Bourin, M; Colombel, MC; Redrobe, JP, 1998) |
| " Nevertheless, (+)-flesinoxan and LY 165,163 mimicked 8-OH-DPAT and WY 48,723 in eliciting a pronounced rise in plasma corticosterone and a marked hypothermia: these actions were blocked by the 5-HT1A receptor antagonist, (-)-alprenolol, but they were not affected by the alpha 1-antagonist prazosin." | 3.69 | 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm. ( Bervoets, K; Canton, H; Gobert, A; Millan, MJ; Rivet, JM; Veiga, S, 1994) |
| "5]- decane-7,9-dione (BMY 7378) (5 mg/kg) did not significantly depress body temperature, but pretreatment with BMY 7378 blocked hypothermia induced by the selective 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)." | 3.68 | Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance. ( Bohmaker, K; Chalfin, M; Meller, E, 1992) |
| "Depression is a major health problem worldwide." | 1.38 | Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. ( Alvarado, G; Artigas, F; Bortolozzi, A; Carmona, MC; Castañé, A; Cortés, R; Fernández, G; Ferrés-Coy, A; Montefeltro, A; Perales, JC; Santana, N; Semakova, J; Toth, M, 2012) |
| "In zatebradine/vehicle-treated rats, the incidence of ventricular and supraventricular premature beats during defeat increased 2." | 1.35 | 8-OH-DPAT prevents cardiac arrhythmias and attenuates tachycardia during social stress in rats. ( Mastorci, F; Nalivaiko, E; Sgoifo, A, 2009) |
| "Down syndrome is produced by the trisomy of chromosome 21." | 1.33 | Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. ( Costa, AC; Scott-McKean, JJ; Stasko, MR, 2006) |
| "Lesopitron inhibits haloperidol-induced catalepsy that is the consequence of its action on 5-HT1A autoreceptors." | 1.32 | Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors. ( Camarasa, J; Escubedo, E; Farré, A; Fisas, MA, 2004) |
| " Analysis of the dose-response curves provided evidence for a 9." | 1.30 | Comparison of relative potencies of i.v. and i.c.v. administered 8-OH-DPAT gives evidence of different sites of action for hypothermia, lower lip retraction and tail flicks. ( Bagdy, G; To, CT, 1997) |
| " A dose-response determination for the tricyclic antidepressants, imipramine and desipramine, the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor, fluoxetine, the 5-HT2 receptor antagonist, ketanserin, the 5-HT1A receptor agonist, (+/-)8-hydroxy-di-propylamino tetralin (8-OH-DPAT) and the dopamine releasing compound, amphetamine, were assessed in both rat stocks." | 1.30 | Holtzman and Harlan Sprague-Dawley rats: differences in DRL 72-sec performance and 8-hydroxy-di-propylamino tetralin-induced hypothermia. ( Balcells-Olivero, M; Cousins, MS; Seiden, LS, 1998) |
| " Acute or chronic treatment of rats with the 5-HT2 receptor antagonist mianserin, or chronic administration of the 5-HT2A receptor antagonist ketanserin, did not alter 8-OH-DPAT-induced hypothermia or forepaw treading." | 1.30 | Effect of chronic serotonin-2 receptor agonist or antagonist administration on serotonin-1A receptor sensitivity. ( Hensler, JG; Truett, KA, 1998) |
| " It has previously been found that chronic administration of corticosterone leads to adrenal suppression and an attenuation of somatodendritic 5-HT1A receptor function." | 1.30 | Effects of adrenalectomy on 8-OH-DPAT induced hypothermia in mice. ( Man, MS; McAllister-Williams, RH; Young, AH, 1999) |
| " Paroxetine, in combination with WAY 100635, attenuated the hypothermic effects of 8-OH-DPAT as early as 3 days, with a full reversal evident following 7 days, whereas paroxetine, although attenuating the hypothermic effects in OB group by day 7, only reversed it fully after 14 days." | 1.30 | Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. ( Cryan, JF; Leonard, BE; McGrath, C; Norman, TR, 1999) |
| "Sumatriptan failed to produce either of these effects due to a poor brain penetration." | 1.29 | 5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates. ( Barf, TA; de Boer, P; Ennis, MD; Ghazal, NB; McGuire, JC; Peroutka, SJ; Smith, MW; Swensson, K; Wikström, H, 1996) |
| "In conclusion, hypothermia is a highly specific and sensitive response to activation of postsynaptic 5-HT1A receptors." | 1.29 | Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. ( Canton, H; Gobert, A; Le Marouille-Girardon, S; Millan, MJ; Rivet, JM, 1993) |
| "Flesinoxan is a high affinity and selective 5-hydroxytryptamine1A (5-HT1A) ligand which, unlike the 5-HT1A agonists of the azapirone class, does not generate 1-(2-pyrimidinyl)piperazine, an alpha 2-adrenoreceptor antagonist." | 1.29 | Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. ( Blier, P; de Montigny, C; Dennis, T; Hadrava, V; Ortemann, C, 1995) |
| " In addition, chronic administration of anxiolytics and neuroleptics was also effective in this respect." | 1.28 | Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. ( Heal, DJ; Hearson, M; Martin, KF; Phillips, I; Prow, MR, 1992) |
| "However, hyperphagia was most evident in diestrous females and least evident in proestrous and estrous rats." | 1.28 | Gender and estrous cycle differences in the response to the 5-HT1A agonist 8-OH-DPAT. ( Caldarola-Pastuszka, M; Salamanca, S; Uphouse, L, 1991) |
| "Neither hypothermia is antagonized by 5-HT1A antagonists (ipsapirone, spiperone), a 5-HT1C antagonist (mesulergine), 5-HT2 antagonists (cyproheptadine, mianserin, methysergide), 5-HT3 antagonists (ICS 205930, metoclopramide)." | 1.27 | Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors? ( Chojnacka-Wójcik, E; Dereń, A; Kłodzińska, A; Maj, J; Moryl, E, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (3.57) | 18.7374 |
| 1990's | 33 (39.29) | 18.2507 |
| 2000's | 31 (36.90) | 29.6817 |
| 2010's | 17 (20.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barf, TA | 1 |
| de Boer, P | 2 |
| Wikström, H | 1 |
| Peroutka, SJ | 1 |
| Swensson, K | 1 |
| Ennis, MD | 1 |
| Ghazal, NB | 1 |
| McGuire, JC | 1 |
| Smith, MW | 1 |
| Mensonides-Harsema, MM | 1 |
| Liao, Y | 1 |
| Böttcher, H | 1 |
| Bartoszyk, GD | 1 |
| Greiner, HE | 1 |
| Harting, J | 1 |
| Wikström, HV | 1 |
| Orús, L | 1 |
| Pérez-Silanes, S | 1 |
| Oficialdegui, AM | 1 |
| Martínez-Esparza, J | 1 |
| Del Castillo, JC | 1 |
| Mourelle, M | 1 |
| Langer, T | 1 |
| Guccione, S | 1 |
| Donzella, G | 1 |
| Krovat, EM | 1 |
| Poptodorov, K | 1 |
| Lasheras, B | 2 |
| Ballaz, S | 2 |
| Hervías, I | 1 |
| Tordera, R | 1 |
| Del Río, J | 2 |
| Monge, A | 1 |
| Herold, F | 1 |
| Izbicki, Ł | 1 |
| Chodkowski, A | 1 |
| Dawidowski, M | 1 |
| Król, M | 1 |
| Kleps, J | 1 |
| Turło, J | 1 |
| Wolska, I | 1 |
| Nowak, G | 1 |
| Stachowicz, K | 1 |
| Dybała, M | 1 |
| Siwek, A | 1 |
| Nowak, M | 1 |
| Pieniazek, E | 1 |
| Jarończyk, M | 1 |
| Sylte, I | 1 |
| Mazurek, AP | 1 |
| Hernández-Hernández, E | 1 |
| Miralles, A | 1 |
| Esteban, S | 1 |
| García-Fuster, MJ | 1 |
| Audero, E | 1 |
| Mlinar, B | 1 |
| Baccini, G | 1 |
| Skachokova, ZK | 1 |
| Corradetti, R | 1 |
| Gross, C | 1 |
| Brandewiede, J | 1 |
| Jakovcevski, M | 1 |
| Stork, O | 1 |
| Schachner, M | 1 |
| Mosienko, V | 1 |
| Matthes, S | 1 |
| Hirth, N | 1 |
| Beis, D | 1 |
| Flinders, M | 1 |
| Bader, M | 1 |
| Hansson, AC | 1 |
| Alenina, N | 1 |
| Kalliokoski, O | 1 |
| Teilmann, AC | 1 |
| Jacobsen, KR | 1 |
| Abelson, KS | 1 |
| Hau, J | 1 |
| Mitchell, E | 1 |
| Klein, SL | 1 |
| Argyropoulos, KV | 1 |
| Sharma, A | 1 |
| Chan, RB | 1 |
| Toth, JG | 1 |
| Barboza, L | 1 |
| Bavley, C | 1 |
| Bortolozzi, A | 3 |
| Chen, Q | 1 |
| Liu, B | 1 |
| Ingenito, J | 1 |
| Mark, W | 1 |
| Dudakov, J | 1 |
| Gross, S | 1 |
| Di Paolo, G | 1 |
| Artigas, F | 3 |
| van den Brink, M | 1 |
| Toth, M | 3 |
| Amigó, J | 1 |
| Díaz, A | 1 |
| Pilar-Cuéllar, F | 1 |
| Vidal, R | 1 |
| Martín, A | 1 |
| Compan, V | 1 |
| Pazos, A | 1 |
| Castro, E | 1 |
| Fox, MA | 1 |
| Jensen, CL | 1 |
| French, HT | 1 |
| Stein, AR | 1 |
| Huang, SJ | 1 |
| Tolliver, TJ | 1 |
| Murphy, DL | 1 |
| Nalivaiko, E | 1 |
| Mastorci, F | 1 |
| Sgoifo, A | 1 |
| Lambás-Señas, L | 1 |
| Mnie-Filali, O | 1 |
| Certin, V | 1 |
| Faure, C | 1 |
| Lemoine, L | 1 |
| Zimmer, L | 1 |
| Haddjeri, N | 1 |
| Li, JX | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| Abbas, AI | 1 |
| Yadav, PN | 1 |
| Yao, WD | 1 |
| Arbuckle, MI | 1 |
| Grant, SG | 1 |
| Caron, MG | 1 |
| Roth, BL | 1 |
| Naumenko, VS | 2 |
| Kondaurova, EM | 1 |
| Popova, NK | 2 |
| Tanaka, K | 1 |
| Kunishige-Yamamoto, A | 1 |
| Hashimoto, H | 1 |
| Shintani, N | 1 |
| Hayata, A | 1 |
| Baba, A | 2 |
| Mombereau, C | 1 |
| Gur, TL | 1 |
| Onksen, J | 1 |
| Blendy, JA | 1 |
| Kõiv, K | 1 |
| Harro, J | 1 |
| Lifschytz, T | 1 |
| Zozulinsky, P | 1 |
| Eitan, R | 1 |
| Landshut, G | 1 |
| Ohayon, S | 1 |
| Lerer, B | 1 |
| Castañé, A | 2 |
| Semakova, J | 1 |
| Santana, N | 2 |
| Alvarado, G | 1 |
| Cortés, R | 2 |
| Ferrés-Coy, A | 2 |
| Fernández, G | 1 |
| Carmona, MC | 2 |
| Perales, JC | 1 |
| Montefeltro, A | 2 |
| Voronova, IP | 1 |
| Khramova, GM | 1 |
| Kozyreva, TV | 1 |
| Diaz, SL | 1 |
| Doly, S | 1 |
| Narboux-Nême, N | 1 |
| Fernández, S | 1 |
| Mazot, P | 1 |
| Banas, SM | 1 |
| Boutourlinsky, K | 1 |
| Moutkine, I | 1 |
| Belmer, A | 1 |
| Roumier, A | 1 |
| Maroteaux, L | 1 |
| Wang, LE | 1 |
| Zhang, XQ | 1 |
| Yin, YQ | 1 |
| Zhang, YH | 1 |
| Renoir, T | 1 |
| Pang, TY | 1 |
| Mo, C | 1 |
| Chan, G | 1 |
| Chevarin, C | 1 |
| Lanfumey, L | 1 |
| Hannan, AJ | 1 |
| Overstreet, DH | 8 |
| Gonzalez, LE | 1 |
| Parada, MA | 1 |
| Tucci, S | 1 |
| Teneud, L | 1 |
| Hernandez, L | 1 |
| Nicholas, AC | 1 |
| Seiden, LS | 3 |
| Shayit, M | 1 |
| Yadid, G | 1 |
| Weller, A | 1 |
| Bouali, S | 1 |
| Evrard, A | 1 |
| Chastanet, M | 1 |
| Lesch, KP | 1 |
| Hamon, M | 1 |
| Adrien, J | 2 |
| Kitamura, Y | 2 |
| Araki, H | 2 |
| Shibata, K | 2 |
| Gomita, Y | 2 |
| Tanizaki, Y | 1 |
| Hedlund, PB | 1 |
| Kelly, L | 1 |
| Mazur, C | 1 |
| Lovenberg, T | 1 |
| Sutcliffe, JG | 1 |
| Bonaventure, P | 1 |
| Fisas, MA | 1 |
| Farré, A | 1 |
| Camarasa, J | 1 |
| Escubedo, E | 1 |
| Visser, SA | 1 |
| Pozarek, S | 1 |
| Martinsson, S | 1 |
| Forsberg, T | 1 |
| Ross, SB | 2 |
| Gabrielsson, J | 1 |
| Bert, B | 1 |
| Fink, H | 1 |
| Hörtnagl, H | 1 |
| Veh, RW | 1 |
| Davies, B | 1 |
| Theuring, F | 1 |
| Kusserow, H | 1 |
| Stasko, MR | 1 |
| Scott-McKean, JJ | 1 |
| Costa, AC | 1 |
| Kitagawa, K | 1 |
| Fujitani, Y | 1 |
| Sendou, T | 1 |
| Popa, D | 1 |
| Léna, C | 1 |
| Alexandre, C | 1 |
| Millan, MJ | 2 |
| Rivet, JM | 2 |
| Gobert, A | 2 |
| Canton, H | 2 |
| Veiga, S | 1 |
| Bervoets, K | 1 |
| Scott, PA | 1 |
| Chou, JM | 1 |
| Tang, H | 1 |
| Frazer, A | 1 |
| Janowsky, DS | 1 |
| Pucilowski, O | 1 |
| Rezvani, AH | 1 |
| Fletcher, A | 2 |
| Bill, DJ | 2 |
| Bill, SJ | 1 |
| Cliffe, IA | 2 |
| Dover, GM | 2 |
| Forster, EA | 2 |
| Haskins, JT | 1 |
| Jones, D | 2 |
| Mansell, HL | 1 |
| Reilly, Y | 2 |
| Le Marouille-Girardon, S | 1 |
| Coudereau, JP | 1 |
| Monier, C | 1 |
| Frances, H | 1 |
| Hadrava, V | 2 |
| Blier, P | 3 |
| Dennis, T | 1 |
| Ortemann, C | 1 |
| de Montigny, C | 2 |
| Mousseau, DD | 1 |
| Rao, VL | 1 |
| Butterworth, RF | 1 |
| O'Connell, MT | 1 |
| Curzon, G | 1 |
| Bagdy, G | 1 |
| To, CT | 1 |
| Lu, JQ | 1 |
| Nagayama, H | 1 |
| Knapp, DJ | 2 |
| Crews, FT | 1 |
| Aguirre, N | 1 |
| Balcells-Olivero, M | 1 |
| Cousins, MS | 2 |
| Cryan, JF | 3 |
| McGrath, C | 2 |
| Leonard, BE | 3 |
| Norman, TR | 2 |
| Hensler, JG | 1 |
| Truett, KA | 1 |
| Darmani, NA | 1 |
| Ahmad, B | 1 |
| Redrobe, JP | 1 |
| Bourin, M | 1 |
| Colombel, MC | 1 |
| Baker, GB | 1 |
| McAllister-Williams, RH | 1 |
| Man, MS | 1 |
| Young, AH | 1 |
| Kelliher, P | 1 |
| Kelly, JP | 1 |
| Vosmer, G | 1 |
| Commissaris, RL | 1 |
| Ardayfio, PA | 1 |
| McQueen, DA | 1 |
| Gilchrist, GA | 1 |
| Sim-Selley, LJ | 1 |
| Breese, GR | 1 |
| Oerther, S | 2 |
| Eltayb, A | 1 |
| Lindblom, S | 1 |
| Ahlenius, S | 1 |
| Zuideveld, KP | 2 |
| Maas, HJ | 2 |
| Treijtel, N | 2 |
| Hulshof, J | 1 |
| van der Graaf, PH | 2 |
| Peletier, LA | 2 |
| Danhof, M | 2 |
| Gubbens-Stibbe, JM | 1 |
| Papaioannou, A | 1 |
| Gerozissis, K | 1 |
| Prokopiou, A | 1 |
| Bolaris, S | 1 |
| Stylianopoulou, F | 1 |
| Kelder, D | 1 |
| Meller, E | 1 |
| Chalfin, M | 1 |
| Bohmaker, K | 1 |
| Martin, KF | 1 |
| Phillips, I | 1 |
| Hearson, M | 1 |
| Prow, MR | 1 |
| Heal, DJ | 2 |
| Reddy, VP | 1 |
| Bhargava, HN | 1 |
| Stockmeier, CA | 1 |
| Wingenfeld, P | 1 |
| Gudelsky, GA | 1 |
| Bouchard, C | 1 |
| Matsuda, T | 1 |
| Nakano, Y | 1 |
| Kanda, T | 1 |
| Iwata, H | 1 |
| Johansson, CE | 1 |
| Meyerson, BJ | 1 |
| Uphouse, L | 1 |
| Salamanca, S | 1 |
| Caldarola-Pastuszka, M | 1 |
| Komissarov, IV | 1 |
| Dolzhenko, AT | 1 |
| Obraztsova, OG | 1 |
| Zin'kovskaia, LIa | 1 |
| Moser, PC | 1 |
| Redfern, PH | 1 |
| Maj, J | 1 |
| Chojnacka-Wójcik, E | 1 |
| Kłodzińska, A | 1 |
| Dereń, A | 1 |
| Moryl, E | 1 |
| Smith, SL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Acute Plasma Tryptophan Depletion on Serotonin Receptor Occupancy and Binding Affinity Using PET in Healthy and Alcoholic Human Subjects[NCT00011752] | 75 participants | Observational | 2001-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 8-hydroxy-2-(di-n-propylamino)tetralin and Hypothermia, Accidental
| Article | Year |
|---|---|
Behavioral characteristics of rat lines selected for differential hypothermic responses to cholinergic or serotonergic agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cholinergic Agonists; Cholinester | 2002 |
Selective breeding of 5-HT(1A) receptor-mediated responses: application to emotion and receptor action.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Breeding; Emotions; | 2000 |
82 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Hypothermia, Accidental
| Article | Year |
|---|---|
5-HT1D receptor agonist properties of novel 2-[5-[[(trifluoromethyl)sulfonyl]oxy]indolyl]ethylamines and their use as synthetic intermediates.
Topics: 5-Hydroxytryptophan; Acrylamides; Animals; Brain; CHO Cells; Cricetinae; Cyclic AMP; Ethylamines; Gu | 1996 |
Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Frontal Lobe; Guinea Pigs; Hypother | 2000 |
Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Carrier Proteins; Frontal Lobe; Hippocampus; Hypoth | 2002 |
Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Hypothermia; Male; Mice; Models, | 2009 |
Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affect; Animals; Behavior, Animal; Fas-Associated Death Doma | 2018 |
Suppression of serotonin neuron firing increases aggression in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Aggression; Animals; Anxiety; Autoradiogr | 2013 |
Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Corticosterone; Hippocampus; Hypothalamo-H | 2013 |
Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Brain; Depression; Female; Hypothermia; Ma | 2014 |
The lonely mouse - single housing affects serotonergic signaling integrity measured by 8-OH-DPAT-induced hypothermia in male mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Depression; Housing, Animal; Hypothermia; Lonelines | 2014 |
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; | 2016 |
The absence of 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anhedonia; Animals; Antidepressive Agents, Second-Generation | 2016 |
Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Brain Chemistry; Catech | 2008 |
8-OH-DPAT prevents cardiac arrhythmias and attenuates tachycardia during social stress in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Arrhythmias, Cardiac; Behavior, Animal; Benzazepine | 2009 |
Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Behavior, Animal; Brain C | 2009 |
Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Diet; DOM 2,5-Dimeth | 2009 |
PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Antipsychot | 2009 |
Central 5-HT3 receptor-induced hypothermia in mice: interstrain differences and comparison with hypothermia mediated via 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Biguanides; Blood-Brain Barrier; Bo | 2009 |
Increased ethanol preference and serotonin 1A receptor-dependent attenuation of ethanol-induced hypothermia in PACAP-deficient mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcoholism; Animals; Behavior, Animal; Conditioning, Classic | 2010 |
Differential effects of acute and repeated citalopram in mouse models of anxiety and depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 2010 |
Differences in 5-HT1A receptor-mediated hypothermia in rats with low or high exploratory activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dose-Response Relationship, Drug; | 2010 |
Effect of triiodothyronine on antidepressant screening tests in mice and on presynaptic 5-HT1A receptors: mediation by thyroid hormone α receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amiodarone; Animals; Antidepressive Agents; Body Weight; Dos | 2011 |
Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Intranasal; Animals; Antidepressive Agents; | 2012 |
Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biguanides; Body Temperature Regulation; Brain; Car | 2011 |
5-HT(2B) receptors are required for serotonin-selective antidepressant actions.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Bromodeoxyuridine; Cell Diffe | 2012 |
Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Aminopyridines; Analysis of Variance; | 2012 |
Acute 5-HT₁A autoreceptor knockdown increases antidepressant responses and serotonin release in stressful conditions.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Behavior, Animal; Disease Models, An | 2013 |
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Depression; Disease Mode | 2013 |
A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Brain; Breeding; Cerebral Cor | 2003 |
Ambient temperature influences core body temperature response in rat lines bred for differences in sensitivity to 8-hydroxy-dipropylaminotetralin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Temperature Regulation; Hypo | 2003 |
5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Tem | 2003 |
Sex hormone-dependent desensitization of 5-HT1A autoreceptors in knockout mice deficient in the 5-HT transporter.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Autoradiography; Autoreceptors; | 2003 |
Modulation of 8-OH-DPAT-induced hypothermia by imipramine in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Drug Synergism; H | 2003 |
8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Temperature Regulation; Fema | 2004 |
Effects of lesopitron on the central nervous system arising from its interaction with 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Catalepsy; Central Nervous System; Central Nervous | 2004 |
Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Body Temperature; Chlormethiazole; Diz | 2005 |
Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Dentate Gyrus; Dose-Response Relat | 2006 |
Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Disease Models, Animal; Down Syndrome; G Pro | 2006 |
The 5-HT1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats: involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Amphetamines; Animals; Body Tem | 2007 |
Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Antidepress | 2008 |
5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-An | 1994 |
Differential induction of 5-HT1A-mediated responses in vivo by three chemically dissimilar 5-HT1A agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Chromans; Hypothermia; Kinetics; | 1994 |
Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Depressive Disorder; Disease | 1994 |
WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Electrophysiology; Female; Guinea | 1993 |
Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists.
Topics: 5-Hydroxytryptophan; 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body | 1993 |
Effect of isolation on behavioural models involving serotonergic 5-HT2 and 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Disease Models, Animal; Hypotherm | 1995 |
A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Binding Sites; Body Temperature; | 1995 |
Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Hippocampus; Hypothermia; Male; Piperazines; Pyrami | 1995 |
Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Animals; Autoradiography; Brain; Brain Chemistry; Ch | 1996 |
Partial agonistic activity of R- and S-enantiomers of 8-OH-DPAT at 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Hippocampus; Hypothermia; Male; Pyramidal Cells; Ra | 1996 |
A comparison of the effects of 8-OH-DPAT pretreatment of different behavioural responses to 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Feeding Behavior; Hypothermia; Ma | 1996 |
Comparison of relative potencies of i.v. and i.c.v. administered 8-OH-DPAT gives evidence of different sites of action for hypothermia, lower lip retraction and tail flicks.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Dose-Response Relationship, D | 1997 |
Circadian rhythm in the hypothermic response to serotonin1A receptor agonist 8-OH-DPAT in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Circadian Rhythm; Dose-Response Relationship, Drug; | 1997 |
Brain 5-HT1A receptor autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT sensitivity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animal Husbandry; Animals; Autoradiography; Body Temperature | 1998 |
MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Hydroxyindoleacetic Acid; Hypotha | 1998 |
Holtzman and Harlan Sprague-Dawley rats: differences in DRL 72-sec performance and 8-hydroxy-di-propylamino tetralin-induced hypothermia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepressive Agents, Tricy | 1998 |
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; | 1998 |
Effect of chronic serotonin-2 receptor agonist or antagonist administration on serotonin-1A receptor sensitivity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cerebral Cortex; Hypothermia; Ketanserin; Male; Mot | 1998 |
Long-term sequential determination of behavioral ontogeny of 5-HT1A and 5-HT2 receptor functions in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Body Temperature; Female; Head Moveme | 1999 |
Psychopharmacological profile of the selective serotonin reuptake inhibitor, paroxetine: implication of noradrenergic and serotonergic mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amines; Animals; Antidepressive Agents; Apomorphine; Brain; | 1998 |
Effects of adrenalectomy on 8-OH-DPAT induced hypothermia in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenalectomy; Animals; Corticosterone; Hypothermia; Mice; M | 1999 |
Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Depressio | 1999 |
Comparative effects of serotonergic agonists with varying efficacy at the 5-HT(1A) receptor on core body temperature: modification by the selective 5-HT(1A) receptor antagonist WAY 100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dose-Response Relationship, Drug; | 1999 |
Rats selectively bred for responsiveness to 5-hydroxytryptamine(1A) receptor stimulation: differences in differential reinforcement of low rate 72-second performance and response to serotonergic drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Uptake Inhibitors; Age Factors; Animals; Behavior | 2000 |
Conflict behavior and the effects of 8-OHDPAT treatment in rats selectively bred for differential 5-HT(1A)-induced hypothermia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Conflict, Psychological; Dose- | 2000 |
Temperature set-point changes induced by DA D2/3 and 5-HT1A receptor agonists in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dopamine Agonists; Hypothermia; M | 2000 |
Additive hypothermic effects of the 5-HT1A receptor agonist 8-OH-DPAT and the dopamine D2/3 receptor agonist 7-OH-DPAT in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Dopamine Agonists; Hypothermia; M | 2001 |
A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature Regulation; Dose-Response Relation | 2001 |
A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Algorithms; Animals; Binding, Competitive; Body Temperature; | 2002 |
Sex differences in the effects of neonatal handling on the animal's response to stress and the vulnerability for depressive behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Corticosterone; Depression; Femal | 2002 |
Counteraction of the rapid tolerance to 8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia in rats by activation of the GABAA receptor-chloride channel complex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Inflammatory Agents; Bod | 2002 |
Serotonin 5-HT1A receptor-mediated hypothermia in mice: absence of spare receptors and rapid induction of tolerance.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Body Temperature; Col | 1992 |
Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Body Temperature; Buspirone; | 1992 |
Abstinence from U-50,488H, a kappa-opiate receptor agonist, decreases the binding of [3H]DPAT to 5-HT1A receptors in the hypothalamus of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy- | 1992 |
Effects of repeated electroconvulsive shock on serotonin1A receptor binding and receptor-mediated hypothermia in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Cerebral Cortex; Electroshock; Hi | 1992 |
Effect of repeated electroconvulsive shocks on serotonergic neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Brain Stem; Dendrites; Electroco | 1992 |
Gonadal hormones affect the hypothermia induced by serotonin1A (5-HT1A) receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Castration; Dose-Response Relatio | 1991 |
The effects of long-term treatment with 8-OH-DPAT on the lordosis response and hypothermia in female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Drug Tolerance; Female; Hypothermia; Posture; Rats; | 1991 |
Gender and estrous cycle differences in the response to the 5-HT1A agonist 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Estrus; Feeding Behavior; Female; | 1991 |
[An analysis of the hypothermic action of 8-hydroxy-2-(di-N-propylamino)tetralin, 1-(2-pyrimidinyl)piperazine and its derivatives].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Buspirone; Dose-Response Relation | 1990 |
Lack of variation over 24-hours in response to stimulation of 5-HT1 receptors in the mouse brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Circadian Rhythm; Hypothermia; Indoles; Male | 1985 |
Hypothermia induced by m-trifluoromethylphenylpiperazine or m-chlorophenylpiperazine: an effect mediated by 5-HT1B receptors?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Hypothermia; Male; Mice; Piperazines; Rats; Rats, I | 1988 |
The effects of acute and repeated administration of T3 to mice on 5-HT1 and 5-HT2 function in the brain and its influence on the actions of repeated electroconvulsive shock.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Electroshock; Hypothermia; Indoles; Male; Mi | 1988 |