8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Hyperactivity, Motor in 12 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amphetamine treatment significantly disrupted PPI in both non-deprived groups, but was absent in both maternally deprived groups." | 1.35 | Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats. ( Choy, KH; van den Buuse, M, 2008) |
| " Dose-response curves created with 8-OH DPAT for the serotonin behavioral syndrome were similar in bile duct-resected and sham-operated rats." | 1.33 | Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat. ( Bozdayi, AM; Bozkaya, H; Celik, T; Cinar, K; Gören, MZ; Gürdal, H; Onder, FO; Tan, A; Terzioğlu, B; Uzunalimoğlu, O; Yurdaydin, C, 2005) |
| " While typical antipsychotics are often switched to atypical agents when adverse effects become limiting, there is little preclinical information to support this strategy, both in terms of efficacy and side effects." | 1.32 | Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine. ( Matsuoka, N; Mutoh, S; Shirakawa, K; Tada, M, 2004) |
| "The influence of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (DPAT) on locomotor hyperactivity induced by the acute and chronic administration of cocaine was assessed." | 1.31 | The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity. ( Cunningham, KA; De La Garza, R, 2000) |
| " In the olfactory bulbectomized rat model of depression, chronic administration (14 days) of metyrapone (50 mg/kg b." | 1.30 | Metyrapone displays antidepressant-like properties in preclinical paradigms. ( Cryan, JF; Harkin, A; Healy, DG; Kelly, JP; Leonard, BE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 8 (66.67) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fox, MA | 1 |
| Panessiti, MG | 1 |
| Hall, FS | 1 |
| Uhl, GR | 1 |
| Murphy, DL | 1 |
| Jabeen, B | 1 |
| Haleem, DJ | 1 |
| Tajiri, M | 1 |
| Hayata-Takano, A | 1 |
| Seiriki, K | 1 |
| Ogata, K | 1 |
| Hazama, K | 1 |
| Shintani, N | 1 |
| Baba, A | 1 |
| Hashimoto, H | 1 |
| Tada, M | 1 |
| Shirakawa, K | 1 |
| Matsuoka, N | 1 |
| Mutoh, S | 1 |
| Müller, CP | 2 |
| Thönnessen, H | 2 |
| De Souza Silva, MA | 1 |
| Fink, H | 1 |
| Bert, B | 1 |
| Carey, RJ | 2 |
| Huston, JP | 2 |
| Barros, M | 1 |
| Tomaz, C | 1 |
| Celik, T | 1 |
| Gören, MZ | 1 |
| Cinar, K | 1 |
| Gürdal, H | 1 |
| Onder, FO | 1 |
| Tan, A | 1 |
| Terzioğlu, B | 1 |
| Bozdayi, AM | 1 |
| Bozkaya, H | 1 |
| Uzunalimoğlu, O | 1 |
| Yurdaydin, C | 1 |
| Choy, KH | 1 |
| van den Buuse, M | 1 |
| Healy, DG | 1 |
| Harkin, A | 1 |
| Cryan, JF | 1 |
| Kelly, JP | 1 |
| Leonard, BE | 1 |
| De La Garza, R | 1 |
| Cunningham, KA | 1 |
| Duxon, MS | 1 |
| Starr, KR | 1 |
| Upton, N | 1 |
| Bristow, LJ | 1 |
| Baucutt, L | 1 |
| Thorn, L | 1 |
| Hutson, PH | 1 |
| Noble, A | 1 |
| Beer, M | 1 |
| Middlemiss, DN | 1 |
| Tricklebank, MD | 1 |
12 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Hyperactivity, Motor
| Article | Year |
|---|---|
An evaluation of the serotonin system and perseverative, compulsive, stereotypical, and hyperactive behaviors in dopamine transporter (DAT) knockout mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Autoreceptors; Brain; Compulsive Beha | 2013 |
Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: implications for sugar-induced obesity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Brain; Dietary Sucro | 2008 |
Serotonin 5-HT(7) receptor blockade reverses behavioral abnormalities in PACAP-deficient mice and receptor activation promotes neurite extension in primary embryonic hippocampal neurons: therapeutic implications for psychiatric disorders.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Cell Count; Cells, Cultured; | 2012 |
Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Antipsychotic Agents; Basal G | 2004 |
Nucleus accumbens serotonin1A receptors control cocaine-induced hyperactivity but not local serotonin increase: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; C | 2004 |
Hippocampus 5-HT(1A)-receptors attenuate cocaine-induced hyperlocomotion and the increase in hippocampal but not nucleus accumbens 5-HT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cocaine; Cocaine-Related Disorders; Dose-Response R | 2004 |
Fatigue of cholestasis and the serotoninergic neurotransmitter system in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Cholestasis; Dose-Response | 2005 |
Attenuated disruption of prepulse inhibition by dopaminergic stimulation after maternal deprivation and adolescent corticosterone treatment in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Animals; Animals, Newborn; Apomorphine; Autorad | 2008 |
Metyrapone displays antidepressant-like properties in preclinical paradigms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepressive Agents, Tricy | 1999 |
The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cocaine; Dose-Response Relationsh | 2000 |
Latency to paroxetine-induced anxiolysis in the rat is reduced by co-administration of the 5-HT(1A) receptor antagonist WAY100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Anima | 2000 |
Behavioural and biochemical evidence of the interaction of the putative antipsychotic agent, BMY 14802 with the 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamine; Animals; Avoidance Learning; Behavior, Animal; | 1991 |