8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Epilepsy in 11 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Tokarski, K | 1 |
| Zahorodna, A | 1 |
| Bobula, B | 1 |
| Hess, G | 1 |
| Salgado, D | 1 |
| Alkadhi, KA | 2 |
| Statnick, MA | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Browning, RA | 1 |
| Salgado-Commissariat, D | 1 |
| Lu, KT | 1 |
| Gean, PW | 1 |
| Filakovszky, J | 1 |
| Kantor, S | 1 |
| Halasz, P | 1 |
| Bagdy, G | 1 |
| Nakamura, M | 1 |
| Wada, Y | 1 |
| Hasegawa, H | 1 |
| Yamaguchi, N | 1 |
| Thompson, PM | 1 |
| Zebrowski, G | 1 |
| Neuman, RS | 1 |
| Janusz, W | 1 |
| Kleinrok, Z | 1 |
| Löscher, W | 1 |
| Czuczwar, SJ | 1 |
11 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Epilepsy
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Comparison of the effects of 5-HT1A and 5-HT4 receptor activation on field potentials and epileptiform activity in rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic | 2002 |
Inhibition of epileptiform activity by serotonin in rat CA1 neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked | 1995 |
Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Dose-Response Relationship, D | 1996 |
Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Convulsants; Drug Evaluation, Preclini | 1996 |
Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Epilepsy; Excitatory Postsynaptic Potential | 1998 |
8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Attention; Behavior, Animal; Dizocilpine Maleate; E | 2001 |
Serotonergic mechanism in hippocampal kindled seizures.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Cats; | 1992 |
Alteration of neocortical activity in response to noxious stimulation: participation of the dorsal raphe.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Baclofen; Cerebral Cortex; Cortical Synchronization | 1991 |
The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Epilepsy; Male; M | 1989 |
Evaluation of the 5-hydroxytryptamine receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin in different rodent models of epilepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Convulsants; Disease Models, Anima | 1985 |