8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Drug Withdrawal Symptoms in 20 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicotine (NIC) and its withdrawal modify dorsal raphe (DR) serotonin (5-HT) neurotransmission in ways that may contribute to the body weight loss vs." | 3.72 | Nicotine and its withdrawal modify dorsal raphe 8-hydroxy-2-(di-n-propylamino) tetralin feeding. ( Bishop, C; Coscina, DV; Parker, GC, 2003) |
| "The escape behaviour induced in rats by injecting D,L-homocysteic acid (DHL) into the dorsal periaqueductal grey area (DPAG) was used as an animal model of panic attacks to investigate the effect of imipramine, a drug used for the treatment of panic disorder, on the sensitivity of 5-HT1A receptors in the DPAG." | 3.69 | Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats. ( Marsden, CA; Mongeau, R, 1997) |
| " In view of a role of 5-hydroxytryptamine (5-HT; serotonin)-1A receptors in the elicitation of EPS, the present study concerns pre- and postsynaptic responses to a selective 5-HT-1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) following acute and chronic administration of haloperidol in rats." | 1.32 | Enhancement of serotonin-1A receptor dependent responses following withdrawal of haloperidol in rats. ( Haleem, DJ; Khan, NH, 2003) |
| "In summary, we conclude that morphine addiction is associated with supersensitivity of 5-HT1A serotonin receptors and alpha2-adrenoceptors (autoreceptors and heteroreceptors) that modulate the synthesis of monoamines in brain." | 1.31 | Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. ( Esteban, S; García-Sevilla, JA; Sastre-Coll, A, 2002) |
| " Further, to evaluate the functional status of the autoreceptors under control conditions and after withdrawal from chronic ethanol, the selective serotonin-1A receptor agonist 8-hydroxy-(2-di-n-propylamino)tetralin was administered intravenously in cumulative doses (1-16 microg/kg) and dose-response curves were generated for both groups." | 1.30 | Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies. ( Diana, M; Gessa, G; Muntoni, AL; Pistis, M, 1997) |
| "Withdrawal from the chronic administration of nicotine has previously been shown to lead to an enhanced auditory startle response in rats." | 1.30 | Serotonin-1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response. ( Helton, DR; Kallman, MJ; Rasmussen, K, 1997) |
| " The sensitivity of serotonergic neurons to 8-OH-DPAT was not changed by the chronic administration of nicotine or saline; slightly increased on day 2 of withdrawal; significantly increased on days 3 and 4 of withdrawal; and no longer significantly increased by day 7 of withdrawal." | 1.30 | Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT1A agonist 8-OH-DPAT. ( Czachura, JF; Rasmussen, K, 1997) |
| " Morphine produces a plethora of pharmacological effects and its chronic administration induces several side-effects." | 1.29 | Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment. ( Cox, BM; Noble, F, 1996) |
| "Umespirone was compared to buspirone, diazepam and clozapine as a potential anxiolytic and antipsychotic agent." | 1.28 | The effects of umespirone as a potential anxiolytic and antipsychotic agent. ( Barnes, NM; Costall, B; Domeney, AM; Gerrard, PA; Kelly, ME; Krähling, H; Naylor, RJ; Tomkins, DM; Williams, TJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (65.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moranta, D | 2 |
| Esteban, S | 3 |
| García-Sevilla, JA | 3 |
| Bishop, C | 1 |
| Parker, GC | 1 |
| Coscina, DV | 1 |
| Haleem, DJ | 1 |
| Khan, NH | 1 |
| Santucci, AC | 1 |
| Madeira, E | 1 |
| Baumann, MH | 2 |
| Becketts, KM | 1 |
| Rothman, RB | 2 |
| King, GR | 1 |
| Joyner, CM | 1 |
| Ellinwood, EH | 1 |
| Kleven, M | 1 |
| Ybema, C | 1 |
| Carilla, E | 1 |
| Hamon, M | 1 |
| Koek, W | 1 |
| Noble, F | 1 |
| Cox, BM | 1 |
| Pistis, M | 1 |
| Muntoni, AL | 1 |
| Gessa, G | 1 |
| Diana, M | 1 |
| Mongeau, R | 1 |
| Marsden, CA | 1 |
| Rasmussen, K | 3 |
| Kallman, MJ | 2 |
| Helton, DR | 1 |
| Czachura, JF | 2 |
| Raap, DK | 1 |
| Garcia, F | 1 |
| Muma, NA | 1 |
| Wolf, WA | 1 |
| Battaglia, G | 1 |
| van de Kar, LD | 1 |
| Calligaro, DO | 1 |
| Dreshfield-Ahmad, LJ | 1 |
| Evans, DC | 1 |
| Hemrick-Luecke, SK | 1 |
| Kendrick, WT | 1 |
| Leander, JD | 1 |
| Nelson, DL | 1 |
| Overshiner, CD | 1 |
| Wainscott, DB | 1 |
| Wolff, MC | 1 |
| Wong, DT | 1 |
| Branchek, TA | 1 |
| Zgombick, JM | 1 |
| Xu, YC | 1 |
| Sastre-Coll, A | 2 |
| Miralles, A | 1 |
| Barnes, NM | 1 |
| Costall, B | 1 |
| Domeney, AM | 1 |
| Gerrard, PA | 1 |
| Kelly, ME | 1 |
| Krähling, H | 1 |
| Naylor, RJ | 1 |
| Tomkins, DM | 1 |
| Williams, TJ | 1 |
| Dzoljic, MR | 1 |
| v Ent, M | 1 |
| Kaplan, CD | 1 |
| Saxena, PR | 1 |
| Gulati, A | 1 |
| Bhargava, HN | 1 |
20 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Benzoxazines; B | 2009 |
Nicotine and its withdrawal modify dorsal raphe 8-hydroxy-2-(di-n-propylamino) tetralin feeding.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Eating; Feeding Behavior; Female; Nico | 2003 |
Enhancement of serotonin-1A receptor dependent responses following withdrawal of haloperidol in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basal Ganglia Diseases; Dopamine Antagonists; Drug | 2003 |
Anxiogenesis in adult rats treated chronically with cocaine during adolescence: effects of extended abstinence and 8-OH-DPAT treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anxiety Disorders; Brain; Brain Chemistry; C | 2008 |
Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Cocaine; Corticosterone; Fenfluramine | 1995 |
Withdrawal from continuous or intermittent cocaine: behavioral responsivity to 5-HT1 receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cocaine; Drug Tolerance; Male; Qu | 1993 |
Modification of behavioral effects of 8-hydroxy-2-(di-n-propylamino)tetralin following chronic ethanol consumption in the rat: evidence for the involvement of 5-HT1A receptors in ethanol dependence.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Corticosterone; Dose-Response Rel | 1995 |
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brai | 1996 |
Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Alcoholism; Analysis of Variance; Animals; | 1997 |
Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Tricyc | 1997 |
Serotonin-1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Auditory Perception; Male; Nicotine; Piperazines; P | 1997 |
Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT1A agonist 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Electrophysiology; Male; Neurons; Nicotine; Nicotin | 1997 |
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal | 1998 |
Sustained desensitization of hypothalamic 5-Hydroxytryptamine1A receptors after discontinuation of fluoxetine: inhibited neuroendocrine responses to 8-hydroxy-2-(Dipropylamino)Tetralin in the absence of changes in Gi/o/z proteins.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Brain; Drug Interactio | 1999 |
The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Body Temperature; Columbidae; | 2000 |
Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Biogenic Monoam | 2002 |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor | 2002 |
The effects of umespirone as a potential anxiolytic and antipsychotic agent.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Brain Ch | 1991 |
Microinjection of 8-OH-DPAT into nucleus accumbens attenuates naloxone-induced morphine withdrawal syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Male; Microinjections; Morphine; Naloxone; Naphthal | 1990 |
Down-regulation of hypothalamic 5-HT1A receptors in morphine-abstinent rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Down-Regulation; Hyp | 1990 |