8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Down Syndrome in 1 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Down syndrome is produced by the trisomy of chromosome 21." | 1.33 | Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome. ( Costa, AC; Scott-McKean, JJ; Stasko, MR, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stasko, MR | 1 |
| Scott-McKean, JJ | 1 |
| Costa, AC | 1 |
1 other study available for 8-hydroxy-2-(di-n-propylamino)tetralin and Down Syndrome
| Article | Year |
|---|---|
Hypothermic responses to 8-OH-DPAT in the Ts65Dn mouse model of Down syndrome.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Disease Models, Animal; Down Syndrome; G Pro | 2006 |