Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin
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8-hydroxy-2-(di-n-propylamino)tetralin and Depressive Disorder

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Depressive Disorder in 23 studies

8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively

Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Research Excerpts

ExcerptRelevanceReference
"Triiodothyronine (T3) has been shown to accelerate and potentiate the clinical response to tricyclic antidepressant (TCA) treatment in depressive disorders."3.71Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain. ( Jeanningros, R; Mazzola-Pomietto, P; Moreau, X, 2001)
" Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats."1.40Chronic administration of 5-HT1A receptor agonist relieves depression and depression-induced hypoalgesia. ( Jiang, ZC; Luo, F; Qi, WJ; Wang, JY, 2014)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's10 (43.48)18.2507
2000's9 (39.13)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jiang, ZC1
Qi, WJ1
Wang, JY1
Luo, F1
Llamosas, N1
Bruzos-Cidón, C1
Rodríguez, JJ1
Ugedo, L1
Torrecilla, M1
Shayit, M1
Yadid, G1
Overstreet, DH5
Weller, A1
Fajardo, O1
Galeno, J1
Urbina, M1
Carreira, I1
Lima, L1
Bellido, I1
Hansson, AC1
Gómez-Luque, AJ1
Andbjer, B1
Agnati, LF1
Fuxe, K1
Lifschytz, T1
Gur, E1
Lerer, B1
Newman, ME1
Popa, D1
Léna, C1
Alexandre, C1
Adrien, J1
Carlsson, A1
Kelly, JP1
Leonard, BE1
Arranz, B1
Eriksson, A1
Mellerup, E1
Plenge, P1
Marcusson, J1
Janowsky, DS3
Pucilowski, O1
Rezvani, AH2
Dey, S1
Przegaliński, E1
Moryl, E1
Papp, M1
Meijer, OC1
Van Oosten, RV1
De Kloet, ER1
Gonzalez, LE1
File, SE1
Daws, LC1
Schiller, GD1
Orbach, J1
Baumann, MH1
Rothman, RB1
Hervás, I1
Vilaró, MT1
Romero, L1
Scorza, MC1
Mengod, G1
Artigas, F1
Kantor, S1
Graf, M1
Anheuer, ZE1
Bagdy, G1
Moreau, X1
Jeanningros, R1
Mazzola-Pomietto, P1
Arango, V1
Underwood, MD1
Boldrini, M1
Tamir, H1
Kassir, SA1
Hsiung, S1
Chen, JJ1
Mann, JJ1
Kennett, GA1
Dourish, CT1
Curzon, G1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Muscarinic Cholinergic Receptor Imaging in Depression[NCT00050700]107 participants (Actual)Observational2002-12-16Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

23 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Depressive Disorder

ArticleYear
Chronic administration of 5-HT1A receptor agonist relieves depression and depression-induced hypoalgesia.
    TheScientificWorldJournal, 2014, Volume: 2014

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Depressive Disorder; Hypesthesia; Locomotion; Male;

2014
Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior.
    The international journal of neuropsychopharmacology, 2015, May-08, Volume: 18, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antidepressive Agents, Second-Ge

2015
5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression.
    Brain research, 2003, Aug-01, Volume: 980, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Tem

2003
Serotonin, serotonin 5-HT(1A) receptors and dopamine in blood peripheral lymphocytes of major depression patients.
    International immunopharmacology, 2003, Volume: 3, Issue:9

    Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Chromatog

2003
Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors.
    Neuroreport, 2004, Jun-28, Volume: 15, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenalectomy; Animals; Corticosterone; Depressive Disorder;

2004
Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences.
    Journal of neuroscience methods, 2004, Dec-30, Volume: 140, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Brain; Brain Chemistry; Depressive D

2004
Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Apr-02, Volume: 28, Issue:14

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Antidepress

2008
Recent observations on new potential and established antidepressant drugs.
    Pharmacopsychiatria, 1982, Volume: 15, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Animals; Antidepressive Agents; Brain; Brompheniramine

1982
The effect of tianeptine and sertraline in three animal models of depression.
    Neuropharmacology, 1994, Volume: 33, Issue:8

    Topics: 1-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepress

1994
Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims.
    Biological psychiatry, 1994, Apr-01, Volume: 35, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Age Factors; Brain; Depressive Disorder;

1994
Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats.
    Psychiatric genetics, 1994,Summer, Volume: 4, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Depressive Disorder; Disease

1994
Physical exercise as a novel antidepressant agent: possible role of serotonin receptor subtypes.
    Physiology & behavior, 1994, Volume: 55, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Defecation; Depressive Disorder;

1994
The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression.
    Neuropharmacology, 1995, Volume: 34, Issue:10

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Depressive Disorder; Disease Models, An

1995
Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression.
    Neuroscience, 1997, Volume: 80, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Glands; Animals; Circadian Rhythm; Corticosterone; D

1997
Selectively bred lines of rats differ in social interaction and hippocampal 5-HT1A receptor function: a link between anxiety and depression?
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Depressive Disorder; Hippocampus; Interper

1998
Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression.
    Pharmacology, biochemistry, and behavior, 1998, Volume: 59, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Body Temperature Regulation; Depressive Diso

1998
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
    Biological psychiatry, 1998, Oct-01, Volume: 44, Issue:7

    Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal

1998
Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Depressive Disorder; Fluoxetine; Male; Neuro

2001
Rapid desensitization of 5-HT(1A) receptors in Fawn-Hooded rats after chronic fluoxetine treatment.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2001, Volume: 11, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety Disorders; Body Temperature; Depressive Dis

2001
Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brai

2001
Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 25, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aged, 80 and over; Autoradiography; Brain Stem;

2001
Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism.
    Biological psychiatry, 1992, May-01, Volume: 31, Issue:9

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Alcoholism; Animals; Arousal; Avoidance Le

1992
Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression.
    European journal of pharmacology, 1987, Feb-24, Volume: 134, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodi

1987