8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Depressive Disorder, Major in 5 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schijven, D | 1 |
| Sousa, VC | 1 |
| Roelofs, J | 1 |
| Olivier, B | 1 |
| Olivier, JD | 1 |
| Underwood, MD | 1 |
| Kassir, SA | 1 |
| Bakalian, MJ | 1 |
| Galfalvy, H | 1 |
| Mann, JJ | 2 |
| Arango, V | 2 |
| Scorza, MC | 1 |
| Lladó-Pelfort, L | 1 |
| Oller, S | 1 |
| Cortés, R | 1 |
| Puigdemont, D | 1 |
| Portella, MJ | 1 |
| Pérez-Egea, R | 1 |
| Alvarez, E | 1 |
| Celada, P | 1 |
| Pérez, V | 1 |
| Artigas, F | 1 |
| Mizrahi, C | 1 |
| Stojanovic, A | 1 |
| Urbina, M | 1 |
| Carreira, I | 1 |
| Lima, L | 1 |
| Huang, YY | 1 |
| Battistuzzi, C | 1 |
| Oquendo, MA | 1 |
| Harkavy-Friedman, J | 1 |
| Greenhill, L | 1 |
| Zalsman, G | 1 |
| Brodsky, B | 1 |
| Brent, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fluoxetine Versus Fluoxetine Plus DU125530 in Latency of Antidepressant Response Shortening in Major Depressive Disorder[NCT01119430] | Phase 2 | 50 participants (Actual) | Interventional | 2004-05-31 | Terminated (stopped due to interim analysis suggested no differences with whole sample) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 8-hydroxy-2-(di-n-propylamino)tetralin and Depressive Disorder, Major
| Article | Year |
|---|---|
Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Animals; Antidepressive Agents; Brain; Depressive Dis | 2012 |
4 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Depressive Disorder, Major
| Article | Year |
|---|---|
Serotonin 1A receptors and sexual behavior in a genetic model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Depressive Disorder, Major; Disease Models, | 2014 |
Neuron density and serotonin receptor binding in prefrontal cortex in suicide.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Autoradiography; Case-Control Studi | 2012 |
Differential cAMP levels and serotonin effects in blood peripheral mononuclear cells and lymphocytes from major depression patients.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Colforsin; Cyclic AMP; Depressive Disorder, Major; Fe | 2004 |
Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Alleles; Anxiety Disorders; Autoradiography; Depressi | 2004 |