8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Depression in 67 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain." | 7.83 | Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. ( Ceci, A; Doods, H; Hu, B; Treede, RD, 2016) |
| " To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied." | 7.69 | Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994) |
| "or s." | 5.72 | The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat. ( Depoortere, R; Jastrzębska-Więsek, M; Kołaczkowski, M; Newman-Tancredi, A; Varney, MA; Wesołowska, A, 2022) |
| "The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain." | 3.83 | Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. ( Ceci, A; Doods, H; Hu, B; Treede, RD, 2016) |
| "Neonatal treatment with clomipramine induces behavioral alterations during adulthood that resemble symptoms observed in human depression." | 3.70 | Pharmacological features of masculine sexual behavior in an animal model of depression. ( Bonilla-Jaime, H; Retana-Marquez, S; Velazquez-Moctezuma, J, 1998) |
| " To further investigate a previous postulate that increased serotonergic activity may cause depression, the effects of chronic mianserin administration on 5-HT, its metabolites, and the subtypes of 5-HT receptors were studied." | 3.69 | Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model. ( Akiyoshi, J; Kuranaga, H; Mizobe, Y; Nagayama, H; Nakamura, M; Tsuchiyama, K, 1994) |
| "or s." | 1.72 | The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat. ( Depoortere, R; Jastrzębska-Więsek, M; Kołaczkowski, M; Newman-Tancredi, A; Varney, MA; Wesołowska, A, 2022) |
| "Depression is one of the most common and disabling mental disorders." | 1.62 | Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression. ( Li, N; Shi, HJ; Sun, YQ; Wang, S; Zhu, LJ, 2021) |
| "Depression is one of the most common neuropsychiatric disturbances in Parkinson's disease (PD), but its pathophysiology is not definite." | 1.56 | Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats. ( Guo, Y; Hu, W; Jiang, YF; La, XM; Liu, J; Wang, HS; Xie, W; Yang, J; Zhang, J; Zhang, L, 2020) |
| "Targeting serotonin (5-HT) bioavailability with selective 5-HT reuptake inhibitors (SSRIs) remains the most widely used treatment for mood disorders." | 1.40 | Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. ( Fisher, RA; Maity, B; Meng, F; Stewart, A; Wemmie, JA; Wu, Q; Wunsch, AM, 2014) |
| "Depression is a common symptom in Parkinson's disease (PD), but its pathophysiology remains unclear." | 1.40 | Activation of prelimbic 5-HT1A receptors produces antidepressant-like effects in a unilateral rat model of Parkinson's disease. ( Chen, L; Guo, Y; Hui, YP; Liu, J; Qiao, HF; Wang, Y; Zhang, L; Zhang, QJ, 2014) |
| " Chronic administration of ACTH caused a significant decrease in hippocampal cell proliferation." | 1.40 | Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats. ( Asanuma, M; Kitamura, Y; Miyake, A; Miyazaki, I; Sendo, T, 2014) |
| "Depression is a major health problem worldwide." | 1.38 | Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects. ( Alvarado, G; Artigas, F; Bortolozzi, A; Carmona, MC; Castañé, A; Cortés, R; Fernández, G; Ferrés-Coy, A; Montefeltro, A; Perales, JC; Santana, N; Semakova, J; Toth, M, 2012) |
| " The chronic administration of m-CPP at the estrous phase produced an anxiolytic effect, while at the proestrous phase, the same drug produced an anxiogenic effect." | 1.37 | [Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats]. ( Fedotova, IuO, 2011) |
| "Depression is the most common psychiatric disorder in Huntington's disease (HD) patients." | 1.37 | Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. ( Chevarin, C; Du, X; Hannan, AJ; Lanfumey, L; Leang, L; Pang, TY; Renoir, T; Zajac, MS, 2011) |
| "We studied the effect of chronic administration of 5-HT(1A)-receptor agonist 8-OH-DPAT (0." | 1.36 | Effects of 8-OH-DPAT and NAN-190 on anxious-depressive-like behavior of female rats during the estrous cycle. ( Fedotova, YO; Ordyan, NE, 2010) |
| "Depression is a multifactorial illness and genetic factors play a role in its etiology." | 1.32 | Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. ( Adrien, J; Bouali, S; Costentin, J; El Yacoubi, M; Hamon, M; Leroux-Nicollet, I; Naudon, L; Popa, D; Vaugeois, JM, 2003) |
| "Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system." | 1.32 | Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom. ( Bae, H; Cho, JH; Hong, M; Jang, CG; Kang, M; Kim, H; Lee, J; Lee, SB; Park, S; Park, SK; Shim, IS; Shin, MK, 2004) |
| "Reboxetine is a non-tricyclic antidepressant with selective noradrenergic (NA) reuptake-blocking effects." | 1.31 | Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. ( Blier, P; Szabo, ST, 2001) |
| "The treatment with alnespirone did not modify baseline 5-HText but significantly attenuated the ability of 0." | 1.30 | Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. ( Artigas, F; Casanovas, JM; Mengod, G; Vilaró, MT, 1999) |
| " Paroxetine, in combination with WAY 100635, attenuated the hypothermic effects of 8-OH-DPAT as early as 3 days, with a full reversal evident following 7 days, whereas paroxetine, although attenuating the hypothermic effects in OB group by day 7, only reversed it fully after 14 days." | 1.30 | Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. ( Cryan, JF; Leonard, BE; McGrath, C; Norman, TR, 1999) |
| " Furthermore, binding studies demonstrate that chronic administration of Fos-inducing agents produces a neuroadaptive downregulation of the 5-HT7 receptor in the hypothalamus." | 1.30 | Effects of antidepressants on 5-HT7 receptor regulation in the rat hypothalamus. ( Eison, AS; Gianutsos, G; Mullins, UL, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.49) | 18.7374 |
| 1990's | 19 (28.36) | 18.2507 |
| 2000's | 20 (29.85) | 29.6817 |
| 2010's | 23 (34.33) | 24.3611 |
| 2020's | 4 (5.97) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Li, J | 2 |
| Huang, Y | 1 |
| Gong, Q | 1 |
| Fu, Y | 1 |
| Xu, Y | 1 |
| Huang, J | 1 |
| You, H | 1 |
| Zhang, D | 2 |
| Mao, F | 1 |
| Zhu, J | 1 |
| Wang, H | 1 |
| Zhang, H | 2 |
| Jastrzębska-Więsek, M | 1 |
| Wesołowska, A | 1 |
| Kołaczkowski, M | 1 |
| Varney, MA | 1 |
| Newman-Tancredi, A | 1 |
| Depoortere, R | 1 |
| Jiang, YF | 1 |
| Liu, J | 2 |
| Yang, J | 1 |
| Guo, Y | 2 |
| Hu, W | 1 |
| Zhang, J | 1 |
| La, XM | 1 |
| Xie, W | 1 |
| Wang, HS | 1 |
| Zhang, L | 3 |
| Zhu, LJ | 1 |
| Sun, YQ | 1 |
| Wang, S | 1 |
| Shi, HJ | 1 |
| Li, N | 1 |
| Hu, P | 1 |
| Ma, L | 1 |
| Wang, YG | 1 |
| Ye, F | 1 |
| Wang, C | 1 |
| Zhou, WH | 1 |
| Zhao, X | 1 |
| Quesseveur, G | 1 |
| David, DJ | 1 |
| Gaillard, MC | 1 |
| Pla, P | 1 |
| Wu, MV | 1 |
| Nguyen, HT | 1 |
| Nicolas, V | 1 |
| Auregan, G | 1 |
| David, I | 1 |
| Dranovsky, A | 1 |
| Hantraye, P | 1 |
| Hen, R | 1 |
| Gardier, AM | 1 |
| Déglon, N | 1 |
| Guiard, BP | 1 |
| Limón-Morales, O | 2 |
| Soria-Fregozo, C | 1 |
| Arteaga-Silva, M | 1 |
| Vázquez-Palacios, G | 2 |
| Bonilla-Jaime, H | 3 |
| Stewart, A | 1 |
| Maity, B | 1 |
| Wunsch, AM | 1 |
| Meng, F | 1 |
| Wu, Q | 1 |
| Wemmie, JA | 1 |
| Fisher, RA | 1 |
| Hui, YP | 1 |
| Zhang, QJ | 1 |
| Chen, L | 1 |
| Qiao, HF | 1 |
| Wang, Y | 1 |
| Miyake, A | 1 |
| Kitamura, Y | 1 |
| Miyazaki, I | 1 |
| Asanuma, M | 1 |
| Sendo, T | 1 |
| Mosienko, V | 1 |
| Matthes, S | 1 |
| Hirth, N | 1 |
| Beis, D | 1 |
| Flinders, M | 1 |
| Bader, M | 1 |
| Hansson, AC | 1 |
| Alenina, N | 1 |
| Fedotova, IuO | 2 |
| Pivina, SG | 1 |
| Akulova, VK | 1 |
| Ordian, NÉ | 1 |
| Kalliokoski, O | 1 |
| Teilmann, AC | 1 |
| Jacobsen, KR | 1 |
| Abelson, KS | 1 |
| Hau, J | 1 |
| Guadarrama-Cruz, G | 1 |
| Alarcon-Aguilar, FJ | 1 |
| Hu, B | 1 |
| Doods, H | 1 |
| Treede, RD | 1 |
| Ceci, A | 1 |
| Luckhart, C | 1 |
| Philippe, TJ | 1 |
| Le François, B | 1 |
| Vahid-Ansari, F | 1 |
| Geddes, SD | 1 |
| Béïque, JC | 1 |
| Lagace, DC | 1 |
| Daigle, M | 1 |
| Albert, PR | 1 |
| Amigó, J | 1 |
| Díaz, A | 1 |
| Pilar-Cuéllar, F | 1 |
| Vidal, R | 1 |
| Martín, A | 1 |
| Compan, V | 1 |
| Pazos, A | 1 |
| Castro, E | 1 |
| Dabrowska, J | 1 |
| Nowak, P | 1 |
| Brus, R | 1 |
| Sharp, SI | 1 |
| Ballard, CG | 1 |
| Ziabreva, I | 1 |
| Piggott, MA | 1 |
| Perry, RH | 1 |
| Perry, EK | 1 |
| Aarsland, D | 1 |
| Ehrt, U | 1 |
| Larsen, JP | 1 |
| Francis, PT | 1 |
| Lambás-Señas, L | 1 |
| Mnie-Filali, O | 1 |
| Certin, V | 1 |
| Faure, C | 1 |
| Lemoine, L | 1 |
| Zimmer, L | 1 |
| Haddjeri, N | 1 |
| Mombereau, C | 1 |
| Gur, TL | 1 |
| Onksen, J | 1 |
| Blendy, JA | 1 |
| Wang, W | 1 |
| Jiang, Z | 1 |
| Shang, J | 1 |
| Fedotova, YO | 1 |
| Ordyan, NE | 1 |
| Idova, GV | 2 |
| Iur'ev, DV | 1 |
| Kuznetsova, SM | 2 |
| Renoir, T | 2 |
| Zajac, MS | 1 |
| Du, X | 1 |
| Pang, TY | 2 |
| Leang, L | 1 |
| Chevarin, C | 2 |
| Lanfumey, L | 2 |
| Hannan, AJ | 2 |
| Bortolozzi, A | 1 |
| Castañé, A | 1 |
| Semakova, J | 1 |
| Santana, N | 1 |
| Alvarado, G | 1 |
| Cortés, R | 1 |
| Ferrés-Coy, A | 1 |
| Fernández, G | 1 |
| Carmona, MC | 1 |
| Toth, M | 1 |
| Perales, JC | 1 |
| Montefeltro, A | 1 |
| Artigas, F | 2 |
| Lifschytz, T | 1 |
| Broner, EC | 1 |
| Zozulinsky, P | 1 |
| Slonimsky, A | 1 |
| Eitan, R | 1 |
| Greenbaum, L | 1 |
| Lerer, B | 2 |
| Jur'ev, DV | 1 |
| Zhukova, EN | 1 |
| Mo, C | 1 |
| Chan, G | 1 |
| El Yacoubi, M | 2 |
| Bouali, S | 1 |
| Popa, D | 1 |
| Naudon, L | 2 |
| Leroux-Nicollet, I | 2 |
| Hamon, M | 1 |
| Costentin, J | 2 |
| Adrien, J | 1 |
| Vaugeois, JM | 2 |
| Bellido, I | 1 |
| Gomez-Luque, A | 1 |
| Garcia-Carrera, P | 1 |
| Rius, F | 1 |
| de la Cuesta, FS | 1 |
| Hernández, A | 1 |
| Constandil, L | 1 |
| Laurido, C | 1 |
| Pelissier, T | 1 |
| Marchand, F | 1 |
| Ardid, D | 1 |
| Alloui, A | 1 |
| Eschalier, A | 1 |
| Soto-Moyano, R | 1 |
| Jang, CG | 1 |
| Kang, M | 1 |
| Cho, JH | 1 |
| Lee, SB | 1 |
| Kim, H | 1 |
| Park, S | 1 |
| Lee, J | 1 |
| Park, SK | 1 |
| Hong, M | 1 |
| Shin, MK | 1 |
| Shim, IS | 1 |
| Bae, H | 1 |
| Roman, V | 1 |
| Walstra, I | 1 |
| Luiten, PG | 1 |
| Meerlo, P | 1 |
| Bekku, N | 1 |
| Yoshimura, H | 1 |
| Araki, H | 1 |
| Zahorodna, A | 1 |
| Hess, G | 1 |
| Boldrini, M | 1 |
| Underwood, MD | 1 |
| Mann, JJ | 1 |
| Arango, V | 1 |
| Hildreth, CM | 1 |
| Padley, JR | 1 |
| Pilowsky, PM | 1 |
| Goodchild, AK | 1 |
| Akiyoshi, J | 1 |
| Tsuchiyama, K | 1 |
| Mizobe, Y | 1 |
| Nakamura, M | 1 |
| Kuranaga, H | 1 |
| Nagayama, H | 1 |
| Matsuda, T | 1 |
| Somboonthum, P | 1 |
| Suzuki, M | 1 |
| Asano, S | 1 |
| Baba, A | 1 |
| Albinsson, A | 1 |
| Björk, A | 1 |
| Svartengren, J | 1 |
| Klint, T | 1 |
| Andersson, G | 1 |
| Papp, M | 1 |
| Klimek, V | 1 |
| Willner, P | 1 |
| De Vry, J | 1 |
| Retana-Marquez, S | 1 |
| Velazquez-Moctezuma, J | 1 |
| Cryan, JF | 2 |
| McGrath, C | 2 |
| Leonard, BE | 3 |
| Norman, TR | 2 |
| Stockmeier, CA | 1 |
| Shapiro, LA | 1 |
| Dilley, GE | 1 |
| Kolli, TN | 1 |
| Friedman, L | 1 |
| Rajkowska, G | 1 |
| Casanovas, JM | 1 |
| Vilaró, MT | 1 |
| Mengod, G | 1 |
| Harkin, A | 1 |
| Kelly, JP | 1 |
| McNamara, M | 1 |
| Connor, TJ | 1 |
| Dredge, K | 1 |
| Redmond, A | 1 |
| File, SE | 1 |
| Ouagazzal, AM | 1 |
| Gonzalez, LE | 1 |
| Overstreet, DH | 1 |
| Kole, MH | 1 |
| Fuchs, E | 1 |
| Ziemann, U | 1 |
| Paulus, W | 1 |
| Ebert, U | 1 |
| Chau, D | 1 |
| Rada, PV | 1 |
| Kosloff, RA | 1 |
| Hoebel, BG | 1 |
| Mullins, UL | 1 |
| Gianutsos, G | 1 |
| Eison, AS | 1 |
| Rasmussen, K | 1 |
| Calligaro, DO | 1 |
| Czachura, JF | 1 |
| Dreshfield-Ahmad, LJ | 1 |
| Evans, DC | 1 |
| Hemrick-Luecke, SK | 1 |
| Kallman, MJ | 1 |
| Kendrick, WT | 1 |
| Leander, JD | 1 |
| Nelson, DL | 1 |
| Overshiner, CD | 1 |
| Wainscott, DB | 1 |
| Wolff, MC | 1 |
| Wong, DT | 1 |
| Branchek, TA | 1 |
| Zgombick, JM | 1 |
| Xu, YC | 1 |
| Onodera, T | 1 |
| Watanabe, R | 1 |
| Tha, KK | 1 |
| Hayashi, Y | 1 |
| Murayama, T | 1 |
| Okuma, Y | 1 |
| Ono, C | 1 |
| Oketani, Y | 1 |
| Hosokawa, M | 1 |
| Nomura, Y | 1 |
| Gur, E | 1 |
| Dremencov, E | 1 |
| Newman, ME | 1 |
| Colpaert, FC | 1 |
| Bruins Slot, LA | 1 |
| Koek, W | 1 |
| Dupuis, DS | 1 |
| Szabo, ST | 1 |
| Blier, P | 1 |
| Papaioannou, A | 1 |
| Gerozissis, K | 1 |
| Prokopiou, A | 1 |
| Bolaris, S | 1 |
| Stylianopoulou, F | 1 |
| Lejeune, F | 1 |
| Gobert, A | 1 |
| Millan, MJ | 1 |
| Kostowski, W | 1 |
| Dyr, W | 1 |
| Krzascik, P | 1 |
| Järbe, T | 1 |
| Archer, T | 1 |
| Engleman, EA | 1 |
| Murphy, JM | 1 |
| Zhou, FC | 1 |
| Hingtgen, JN | 1 |
| Kennett, GA | 1 |
| Cervo, L | 2 |
| Samanin, R | 2 |
| Grignaschi, G | 1 |
| Nowakowska, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double Blind, Randomized, Placebo Controlled Clinical Trial to Evaluate the Efficacy of Repetitive Transcranial Magnetic Stimulation in Patients Victims of Landmines With Phantom Limb Pain[NCT01872481] | Phase 3 | 54 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for 8-hydroxy-2-(di-n-propylamino)tetralin and Depression
| Article | Year |
|---|---|
5-HT1A receptor agonists: recent developments and controversial issues.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Depression; Humans; Serotonin; Serotonin R | 1995 |
Mechanisms of serotonergic affect control.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Busp | 1991 |
65 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Depression
| Article | Year |
|---|---|
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antidepressive Agents; Binding Sites; Brain; Choli | 2022 |
The selective 5-HT 1A receptor agonist, NLX-112, overcomes tetrabenazine-induced catalepsy and depression-like behavior in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Buspirone; Catalepsy; Depres | 2022 |
Involvement of the Dorsal Hippocampus 5-HT1A Receptors in the Regulation of Depressive-Like Behaviors in Hemiparkinsonian Rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Behavior, Animal; Depression; Disease Mod | 2020 |
Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylation; Animals; Depression; Hippocampus; Histone Deace | 2021 |
Genistein, a dietary soy isoflavone, exerts antidepressant-like effects in mice: Involvement of serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Depression; Dose-Response Re | 2017 |
BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 2013 |
Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Body Temperature; Clomipra | 2014 |
Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Animals, Newborn; Anxiety; Cells | 2014 |
Activation of prelimbic 5-HT1A receptors produces antidepressant-like effects in a unilateral rat model of Parkinson's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Depression; Dietary Sucrose; | 2014 |
Effects of (+)-8-OH-DPAT on the duration of immobility during the forced swim test and hippocampal cell proliferation in ACTH-treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Antidepressive Agents; | 2014 |
Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Brain; Depression; Female; Hypothermia; Ma | 2014 |
[Effects of 8-OH-DPAT and m-CPP on depression-like behavior in prenatally stressed ovariectomized rats treated with low dose of 17beta-estradiol].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Depression; Estradiol; Estrogens; | 2014 |
The lonely mouse - single housing affects serotonergic signaling integrity measured by 8-OH-DPAT-induced hypothermia in male mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Depression; Housing, Animal; Hypothermia; Lonelines | 2014 |
Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Biological Products; Depress | 2015 |
Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Neurons; Analgesics; Animals; Antidepressive Agen | 2016 |
Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Physiological; Animals; Anxiety; Behavior, Anima | 2016 |
The absence of 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anhedonia; Animals; Antidepressive Agents, Second-Generation | 2016 |
Reactivity of 5-HT1A receptor in adult rats after neonatal noradrenergic neurons' lesion--implications for antidepressant-like action.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Agents; Animals; Animals, Newborn; Antidepressive | 2008 |
Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Antidepressive Agents; Antiparkinso | 2008 |
Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Behavior, Animal; Brain C | 2009 |
Differential effects of acute and repeated citalopram in mouse models of anxiety and depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 2010 |
Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Depression; Fluoxetine; Interferon-alpha | 2010 |
Effects of 8-OH-DPAT and NAN-190 on anxious-depressive-like behavior of female rats during the estrous cycle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety Disorders; Depression | 2010 |
[Immune response under activation of pre- and postsynaptic serotonin 5-HT1A-receptors in mice with depressive-like behavior].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antibody Formation; Autoreceptors; Depression; Male | 2010 |
[Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; D | 2011 |
Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Depression; Disease Models, Anima | 2011 |
Selective siRNA-mediated suppression of 5-HT1A autoreceptors evokes strong anti-depressant-like effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Intranasal; Animals; Antidepressive Agents; | 2012 |
Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety; Brain Chemistry; Dep | 2012 |
Immune response during activation of pre- and postsynaptic serotonin 5-HT(1A) receptors in C57Bl/6J mice at various stages of a depression-like state.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antibody-Producing Cells; Behavior, Animal; Depress | 2011 |
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Depression; Disease Mode | 2013 |
Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Animals; Antidepressive Agents; A | 2003 |
Female rats show an increased sensibility to the forced swim test depressive-like stimulus in the hippocampus and frontal cortex 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Depression; Exploratory Behavior; | 2003 |
Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Body Temper | 2004 |
Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like symptom.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Autoradiography; Depression; | 2004 |
Too little sleep gradually desensitizes the serotonin 1A receptor system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Chronic Disease; Depression; Dise | 2005 |
Factors producing a menopausal depressive-like state in mice following ovariectomy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affect; Amphetamines; Animals; Depression; Disease Models, A | 2006 |
Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT(1A) and 5-HT(2) receptors in rat frontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Second-Generat | 2006 |
Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Autoradiography; Autoreceptors; Binding Sites; Carrier Prote | 2008 |
Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autonomic Nervous System; Baroreflex; Blood Pressur | 2008 |
Effects of chronic mianserin administration on serotonin metabolism and receptors in the 5-hydroxytryptophan depression model.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain Chemistry; Cerebral Cort | 1994 |
Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Dep | 1995 |
Preclinical pharmacology of FG5893: a potential anxiolytic drug with high affinity for both 5-HT1A and 5-HT2A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, | 1994 |
Effects of imipramine on serotonergic and beta-adrenergic receptor binding in a realistic animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Depression; Dihydroalprenolol; Im | 1994 |
Pharmacological features of masculine sexual behavior in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Clo | 1998 |
Combining pindolol and paroxetine in an animal model of chronic antidepressant action--can early onset of action be detected?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; | 1998 |
Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aged, 80 and over; Autoreceptors; Depression; F | 1998 |
Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Brain Chemistry; Dendrite | 1999 |
Activity and onset of action of reboxetine and effect of combination with sertraline in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analgesics; Animals; Antidepressive Agents; Body T | 1999 |
Chronic fluoxetine in tests of anxiety in rat lines selectively bred for differential 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 1999 |
Changes in 5-HT1A and NMDA binding sites by a single rapid transcranial magnetic stimulation procedure in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Autoradiography; Brain Chemistry; Cerebra | 1999 |
Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Depressio | 1999 |
Cholinergic, M1 receptors in the nucleus accumbens mediate behavioral depression. A possible downstream target for fluoxetine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Arecoline; Depression; Female; Fluox | 1999 |
Effects of antidepressants on 5-HT7 receptor regulation in the rat hypothalamus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Circadian Rhythm; Depression | 1999 |
The novel 5-Hydroxytryptamine(1A) antagonist LY426965: effects on nicotine withdrawal and interactions with fluoxetine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Body Temperature; Columbidae; | 2000 |
Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Benzazepines; Brain; Depre | 2000 |
Chronic repetitive transcranial magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor activity in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Depression; Male; Microdialysis; Oxa | 2000 |
Memory of an operant response and of depressed mood retained in activation states of 5-HT(1A) receptors: evidence from rodent models.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Behavior, Animal; Conditionin | 2000 |
Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-Agonists; Adrenergic Upt | 2001 |
Sex differences in the effects of neonatal handling on the animal's response to stress and the vulnerability for depressive behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Corticosterone; Depression; Femal | 2002 |
A chronic treatment with fluoxetine decreases 5-HT(1A) receptors labeling in mice selected as a genetic model of helplessness.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Brain; Depression; Disease Mo | 2002 |
The selective neurokinin (NK)(1) antagonist, GR205,171, stereospecifically enhances mesocortical dopaminergic transmission in the rat: a combined dialysis and electrophysiological study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antiemetics; Apomorphine; Depres | 2002 |
5-Hydroxytryptamine1A receptor agonists in animal models of depression and anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Buspirone; Chromans; Depression; Disease M | 1992 |
Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Depression; Disease | 1992 |
Effect of chronic treatment with 8-OH-DPAT in the forced swimming test requires the integrity of presynaptic serotonergic mechanisms.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Conditioning, Operant; Dep | 1991 |
1-(3-Trifluoromethylphenyl) piperazine (TFMPP) in the ventral tegmental area reduces the effect of desipramine in the forced swimming test in rats: possible role of serotonin receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Depression; Desipramine; Injections; Male; Metergol | 1989 |