8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Depression, Endogenous in 23 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Excerpt | Relevance | Reference |
---|---|---|
"Triiodothyronine (T3) has been shown to accelerate and potentiate the clinical response to tricyclic antidepressant (TCA) treatment in depressive disorders." | 3.71 | Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain. ( Jeanningros, R; Mazzola-Pomietto, P; Moreau, X, 2001) |
" Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats." | 1.40 | Chronic administration of 5-HT1A receptor agonist relieves depression and depression-induced hypoalgesia. ( Jiang, ZC; Luo, F; Qi, WJ; Wang, JY, 2014) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (8.70) | 18.7374 |
1990's | 10 (43.48) | 18.2507 |
2000's | 9 (39.13) | 29.6817 |
2010's | 2 (8.70) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Jiang, ZC | 1 |
Qi, WJ | 1 |
Wang, JY | 1 |
Luo, F | 1 |
Llamosas, N | 1 |
Bruzos-Cidón, C | 1 |
Rodríguez, JJ | 1 |
Ugedo, L | 1 |
Torrecilla, M | 1 |
Shayit, M | 1 |
Yadid, G | 1 |
Overstreet, DH | 5 |
Weller, A | 1 |
Fajardo, O | 1 |
Galeno, J | 1 |
Urbina, M | 1 |
Carreira, I | 1 |
Lima, L | 1 |
Bellido, I | 1 |
Hansson, AC | 1 |
Gómez-Luque, AJ | 1 |
Andbjer, B | 1 |
Agnati, LF | 1 |
Fuxe, K | 1 |
Lifschytz, T | 1 |
Gur, E | 1 |
Lerer, B | 1 |
Newman, ME | 1 |
Popa, D | 1 |
Léna, C | 1 |
Alexandre, C | 1 |
Adrien, J | 1 |
Carlsson, A | 1 |
Kelly, JP | 1 |
Leonard, BE | 1 |
Arranz, B | 1 |
Eriksson, A | 1 |
Mellerup, E | 1 |
Plenge, P | 1 |
Marcusson, J | 1 |
Janowsky, DS | 3 |
Pucilowski, O | 1 |
Rezvani, AH | 2 |
Dey, S | 1 |
Przegaliński, E | 1 |
Moryl, E | 1 |
Papp, M | 1 |
Meijer, OC | 1 |
Van Oosten, RV | 1 |
De Kloet, ER | 1 |
Gonzalez, LE | 1 |
File, SE | 1 |
Daws, LC | 1 |
Schiller, GD | 1 |
Orbach, J | 1 |
Baumann, MH | 1 |
Rothman, RB | 1 |
Hervás, I | 1 |
Vilaró, MT | 1 |
Romero, L | 1 |
Scorza, MC | 1 |
Mengod, G | 1 |
Artigas, F | 1 |
Kantor, S | 1 |
Graf, M | 1 |
Anheuer, ZE | 1 |
Bagdy, G | 1 |
Moreau, X | 1 |
Jeanningros, R | 1 |
Mazzola-Pomietto, P | 1 |
Arango, V | 1 |
Underwood, MD | 1 |
Boldrini, M | 1 |
Tamir, H | 1 |
Kassir, SA | 1 |
Hsiung, S | 1 |
Chen, JJ | 1 |
Mann, JJ | 1 |
Kennett, GA | 1 |
Dourish, CT | 1 |
Curzon, G | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Muscarinic Cholinergic Receptor Imaging in Depression[NCT00050700] | 107 participants (Actual) | Observational | 2002-12-16 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
23 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Depression, Endogenous
Article | Year |
---|---|
Chronic administration of 5-HT1A receptor agonist relieves depression and depression-induced hypoalgesia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Depressive Disorder; Hypesthesia; Locomotion; Male; | 2014 |
Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Antidepressive Agents, Second-Ge | 2015 |
5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Tem | 2003 |
Serotonin, serotonin 5-HT(1A) receptors and dopamine in blood peripheral lymphocytes of major depression patients.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Chromatog | 2003 |
Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenalectomy; Animals; Corticosterone; Depressive Disorder; | 2004 |
Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: regional differences.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoreceptors; Brain; Brain Chemistry; Depressive D | 2004 |
Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Animals, Newborn; Antidepress | 2008 |
Recent observations on new potential and established antidepressant drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Animals; Antidepressive Agents; Brain; Brompheniramine | 1982 |
The effect of tianeptine and sertraline in three animal models of depression.
Topics: 1-Naphthylamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Antidepress | 1994 |
Brain 5-HT1A, 5-HT1D, and 5-HT2 receptors in suicide victims.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Age Factors; Brain; Depressive Disorder; | 1994 |
Swim test immobility co-segregates with serotonergic but not cholinergic sensitivity in cross-breeds of Flinders Line rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Depressive Disorder; Disease | 1994 |
Physical exercise as a novel antidepressant agent: possible role of serotonin receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Defecation; Depressive Disorder; | 1994 |
The effect of 5-HT1A receptor ligands in a chronic mild stress model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Depressive Disorder; Disease Models, An | 1995 |
Elevated basal trough levels of corticosterone suppress hippocampal 5-hydroxytryptamine(1A) receptor expression in adrenally intact rats: implication for the pathogenesis of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Glands; Animals; Circadian Rhythm; Corticosterone; D | 1997 |
Selectively bred lines of rats differ in social interaction and hippocampal 5-HT1A receptor function: a link between anxiety and depression?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Depressive Disorder; Hippocampus; Interper | 1998 |
Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Body Temperature Regulation; Depressive Diso | 1998 |
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal | 1998 |
Desensitization of 5-HT(1A) autoreceptors by a low chronic fluoxetine dose effect of the concurrent administration of WAY-100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Depressive Disorder; Fluoxetine; Male; Neuro | 2001 |
Rapid desensitization of 5-HT(1A) receptors in Fawn-Hooded rats after chronic fluoxetine treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety Disorders; Body Temperature; Depressive Dis | 2001 |
Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brai | 2001 |
Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aged, 80 and over; Autoradiography; Brain Stem; | 2001 |
Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Alcoholism; Animals; Arousal; Avoidance Le | 1992 |
Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodi | 1987 |