8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Dementia Praecox in 20 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| "Catalepsy was measured in rats using both the cross-legged position test and the bar test." | 5.31 | Repeated treatment with 8-OH-DPAT induces tolerance to its ability to produce the 5-HT1A behavioural syndrome, but not to its ability to attenuate haloperidol-induced catalepsy. ( Colpaert, FC; Kleven, MS; Koek, W; Prinssen, EP, 2000) |
| " Volinanserin also increased PPI in control and MK-801-treated mice, presenting an inverted U-shaped dose-response curve." | 1.56 | Effects of combined 5-HT ( Cardoso, AR; Castro, NG; Hammes, CSO; Macena, MV; Marques, AM; Neves, GA; Pinheiro, FML, 2020) |
| " While typical antipsychotics are often switched to atypical agents when adverse effects become limiting, there is little preclinical information to support this strategy, both in terms of efficacy and side effects." | 1.32 | Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine. ( Matsuoka, N; Mutoh, S; Shirakawa, K; Tada, M, 2004) |
| "Catalepsy was measured in rats using both the cross-legged position test and the bar test." | 1.31 | Repeated treatment with 8-OH-DPAT induces tolerance to its ability to produce the 5-HT1A behavioural syndrome, but not to its ability to attenuate haloperidol-induced catalepsy. ( Colpaert, FC; Kleven, MS; Koek, W; Prinssen, EP, 2000) |
| "Pretreatment with haloperidol (13 to 130 nmol/kg sc), but not equimolar doses of UH 232, prevented the disruption of PPI produced by the highest dose (0." | 1.29 | Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat. ( Caine, SB; Geyer, MA; Swerdlow, NR, 1995) |
| " Parallel analyses of rat brain tissue showed no changes in 5-HT1A or 5-HT2A receptor mRNAs or binding site densities after chronic administration of haloperidol." | 1.29 | 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. ( Burnet, PW; Eastwood, SL; Harrison, PJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (60.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 3 (15.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marques, AM | 1 |
| Macena, MV | 1 |
| Cardoso, AR | 1 |
| Hammes, CSO | 1 |
| Pinheiro, FML | 1 |
| Castro, NG | 1 |
| Neves, GA | 1 |
| Thwaites, SJ | 1 |
| Gogos, A | 2 |
| Van den Buuse, M | 3 |
| Kwek, P | 1 |
| Tada, M | 1 |
| Shirakawa, K | 1 |
| Matsuoka, N | 1 |
| Mutoh, S | 1 |
| Huang, YY | 1 |
| Battistuzzi, C | 1 |
| Oquendo, MA | 1 |
| Harkavy-Friedman, J | 1 |
| Greenhill, L | 1 |
| Zalsman, G | 1 |
| Brodsky, B | 1 |
| Arango, V | 1 |
| Brent, DA | 1 |
| Mann, JJ | 1 |
| Gray, L | 1 |
| Scarr, E | 1 |
| Dean, B | 1 |
| Caine, SB | 1 |
| Geyer, MA | 1 |
| Swerdlow, NR | 1 |
| Taubes, G | 1 |
| Sumiyoshi, T | 1 |
| Stockmeier, CA | 1 |
| Overholser, JC | 1 |
| Dilley, GE | 1 |
| Meltzer, HY | 1 |
| Burnet, PW | 2 |
| Eastwood, SL | 2 |
| Harrison, PJ | 2 |
| Simpson, MD | 2 |
| Lubman, DI | 1 |
| Slater, P | 3 |
| Deakin, JF | 3 |
| Doyle, CA | 1 |
| Lahti, AC | 1 |
| Weiler, M | 1 |
| Carlsson, A | 1 |
| Tamminga, CA | 1 |
| Prinssen, EP | 1 |
| Koek, W | 1 |
| Colpaert, FC | 1 |
| Kleven, MS | 1 |
| Hrib, NJ | 1 |
| Jurcak, JG | 1 |
| Bregna, DE | 1 |
| Dunn, RW | 1 |
| Geyer, HM | 1 |
| Hartman, HB | 1 |
| Roehr, JE | 1 |
| Rogers, KL | 1 |
| Rush, DK | 1 |
| Szczepanik, AM | 1 |
| Royston, MC | 1 |
| Rigdon, GC | 1 |
| Weatherspoon, JK | 1 |
| Hashimoto, T | 1 |
| Nishino, N | 1 |
| Nakai, H | 1 |
| Tanaka, C | 1 |
1 trial available for 8-hydroxy-2-(di-n-propylamino)tetralin and Dementia Praecox
| Article | Year |
|---|---|
Effects of the D3 and autoreceptor-preferring dopamine antagonist (+)-UH232 in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Autoreceptors; Behavior; Dopamine Antagonists; Dose-R | 1998 |
19 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Dementia Praecox
| Article | Year |
|---|---|
Effects of combined 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzoxazines; Cannabinoid Receptor Antagonists; Can | 2020 |
Schizophrenia-like disruptions of sensory gating by serotonin receptor stimulation in rats: effect of MDMA, DOI and 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Evoked Potentials; Male; N-Methyl-3,4 | 2013 |
The role of estrogen and testosterone in female rats in behavioral models of relevance to schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dizocilpine Maleate; Estrogens; Female; Ovariectomy | 2012 |
Exploring the role of 5-HT1A receptors in the regulation of prepulse inhibition in mice: implications for cross-species comparisons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Ligands; Mice; Mi | 2013 |
Combined treatment of quetiapine with haloperidol in animal models of antipsychotic effect and extrapyramidal side effects: comparison with risperidone and chlorpromazine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Antipsychotic Agents; Basal G | 2004 |
Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Alleles; Anxiety Disorders; Autoradiography; Depressi | 2004 |
Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Bipolar Disorder; Brain Mapping; Female; Fronta | 2006 |
Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Apomorphine; Dopamine Agonist | 1995 |
Will new dopamine receptors offer a key to schizophrenia?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Brain; Clozapine; Dopamine Antagonists; Humans; Receptors, D | 1994 |
Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Autopsy; Female; Humans; Kinetics; Male; Middle Aged; | 1996 |
5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Animals; Antipsychotic Agents; Autoradiography; | 1996 |
[3H]WAY-100635 for 5-HT1A receptor autoradiography in human brain: a comparison with [3H]8-OH-DPAT and demonstration of increased binding in the frontal cortex in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Autoradiography; Female; Frontal Lobe; Humans; | 1997 |
Autoradiography with [3H]8-OH-DPAT reveals increases in 5-HT(1A) receptors in ventral prefrontal cortex in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Autoradiography; Female; Humans; Male; Middle Aged; Prefront | 1996 |
Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebellum; Chronic Disease; Female; | 1998 |
Repeated treatment with 8-OH-DPAT induces tolerance to its ability to produce the 5-HT1A behavioural syndrome, but not to its ability to attenuate haloperidol-induced catalepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Behav | 2000 |
3-[4-[1-(6-Fluorobenzo[b]thiophen-3-yl)-4-piperazinyl]butyl]- 2,5,5-trimethyl-4-thiazolidinone: a new atypical antipsychotic agent for the treatment of schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Mice; Rats; Receptors, Dopami | 1992 |
Social signalling and schizophrenia: the significance of neurochemical and morphological abnormalities of the basolateral circuit.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Brain Chemistry; Frontal Lobe; Humans; Schizophrenia; Schizo | 1992 |
5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Buspirone; Dose-Response Rela | 1992 |
Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Binding, Competitive; Cell Membrane; Cerebral Cortex; | 1991 |