8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Chronic Disease in 11 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain." | 7.83 | Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. ( Ceci, A; Doods, H; Hu, B; Treede, RD, 2016) |
| "The present study was undertaken to evaluate the potential role of 5-HT(1A) receptors and opioids receptors in the analgesic effect of tramadol in neuropathic pain." | 7.74 | Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. ( Berrocoso, E; De Benito, MD; Mico, JA, 2007) |
| "The current study assessed whether antidepressant and/or antinociceptive drugs, duloxetine, fluoxetine as well as (±)-8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT), are able to reverse depression-like behaviour in animals with chronic neuropathic pain." | 3.83 | Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain. ( Ceci, A; Doods, H; Hu, B; Treede, RD, 2016) |
| "The present study was undertaken to evaluate the potential role of 5-HT(1A) receptors and opioids receptors in the analgesic effect of tramadol in neuropathic pain." | 3.74 | Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats. ( Berrocoso, E; De Benito, MD; Mico, JA, 2007) |
| " Dose-response curves for i." | 1.32 | Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. ( Dolber, PC; Gu, B; Olejar, KJ; Reiter, JP; Thor, KB, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 8 (72.73) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liao, S | 1 |
| Lv, J | 1 |
| Zhou, J | 1 |
| Kalavagunta, PK | 1 |
| Shang, J | 1 |
| Hu, B | 1 |
| Doods, H | 1 |
| Treede, RD | 1 |
| Ceci, A | 1 |
| Bambico, FR | 1 |
| Nguyen, NT | 1 |
| Gobbi, G | 1 |
| Gu, B | 2 |
| Olejar, KJ | 1 |
| Reiter, JP | 2 |
| Thor, KB | 2 |
| Dolber, PC | 2 |
| Grippo, AJ | 1 |
| Sullivan, NR | 1 |
| Damjanoska, KJ | 1 |
| Crane, JW | 1 |
| Carrasco, GA | 1 |
| Shi, J | 1 |
| Chen, Z | 1 |
| Garcia, F | 1 |
| Muma, NA | 1 |
| Van de Kar, LD | 1 |
| Roman, V | 1 |
| Walstra, I | 1 |
| Luiten, PG | 1 |
| Meerlo, P | 1 |
| Tai, C | 1 |
| Miscik, CL | 1 |
| Ungerer, TD | 1 |
| Roppolo, JR | 1 |
| de Groat, WC | 1 |
| Zhang, X | 1 |
| Fraser, MO | 1 |
| Berrocoso, E | 1 |
| De Benito, MD | 1 |
| Mico, JA | 1 |
| Slater, P | 1 |
| Doyle, CA | 1 |
| Deakin, JF | 1 |
| Esteban, S | 1 |
| Moranta, D | 1 |
| Sastre-Coll, A | 1 |
| Miralles, A | 1 |
| García-Sevilla, JA | 1 |
11 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Chronic Disease
| Article | Year |
|---|---|
Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Cell Line, Tumor; Cell Proliferat | 2017 |
Duloxetine and 8-OH-DPAT, but not fluoxetine, reduce depression-like behaviour in an animal model of chronic neuropathic pain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic Neurons; Analgesics; Animals; Antidepressive Agen | 2016 |
Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Analysis of Variance; Animals; Chronic Di | 2009 |
Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acrylamides; Animals; Blood Pressure; Carotid Arteries; Cats | 2004 |
Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Chronic Disease; Drinking; Estrous Cyc | 2005 |
Too little sleep gradually desensitizes the serotonin 1A receptor system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Chronic Disease; Depression; Dise | 2005 |
Suppression of bladder reflex activity in chronic spinal cord injured cats by activation of serotonin 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cats; Chronic Disease; Disease Models, Animal; Fema | 2006 |
Activation of the external urethral sphincter central pattern generator by a 5-HT(1A) receptor agonist in rats with chronic spinal cord injury.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Chronic Disease; Dose-Response Relationship, Drug; | 2007 |
Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Chronic Disease; Disease Models | 2007 |
Abnormal persistence of cerebellar serotonin-1A receptors in schizophrenia suggests failure to regress in neonates.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Autoradiography; Cerebellum; Chronic Disease; Female; | 1998 |
Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Cerebral Cor | 2002 |