Compounds > 8-hydroxy-2-(di-n-propylamino)tetralin
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8-hydroxy-2-(di-n-propylamino)tetralin and Body Weight

8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Body Weight in 40 studies

8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
" The present study examined the impact of a tryptophan-deficient diet and fluoxetine on the serotonergic regulation of neuroendocrine function and body weight."7.72Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet. ( Battaglia, G; D'Souza, DN; Garcia, F; Van de Kar, LD; Zhang, Y, 2004)
"Nicotine (NIC) and its withdrawal modify dorsal raphe (DR) serotonin (5-HT) neurotransmission in ways that may contribute to the body weight loss vs."3.72Nicotine and its withdrawal modify dorsal raphe 8-hydroxy-2-(di-n-propylamino) tetralin feeding. ( Bishop, C; Coscina, DV; Parker, GC, 2003)
" The present study examined the impact of a tryptophan-deficient diet and fluoxetine on the serotonergic regulation of neuroendocrine function and body weight."3.72Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet. ( Battaglia, G; D'Souza, DN; Garcia, F; Van de Kar, LD; Zhang, Y, 2004)
"Injections of 10 mg/kg fluoxetine produced a significant decrease in body weight gain."3.71Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT(1A) receptors. ( Battaglia, G; D'Souza, DN; Garcia, F; Van De Kar, LD; Zhang, Y, 2002)
"Triiodothyronine (T3) has been shown to accelerate and potentiate the clinical response to tricyclic antidepressant (TCA) treatment in depressive disorders."3.71Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain. ( Jeanningros, R; Mazzola-Pomietto, P; Moreau, X, 2001)
"Fluoxetine treatment completely blocked the oxytocin, ACTH and corticosterone responses to 8-OH-DPAT, but did not inhibit the effect of DOI on any hormone, thus confirming that fluoxetine treatment did not produce a deficit in the functioning of corticotropin releasing hormone or oxytocin containing neurons."1.31Treatment of cycling female rats with fluoxetine induces desensitization of hypothalamic 5-HT(1A) receptors with no change in 5-HT(2A) receptors. ( Battaglia, G; DonCarlos, LL; Garcia, F; Muma, NA; Raap, DK; Van de Kar, LD, 2002)
"The present studies examined the dose-response relationship of fluoxetine-induced desensitization of hypothalamic postsynaptic 5-HT1A receptors, as measured from the reduced neuroendocrine responses to a 5-HT1A agonist."1.30Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins. ( Battaglia, G; Evans, S; Garcia, F; Li, Q; Muma, NA; Raap, DK; Van De Kar, LD; Wolf, WA, 1999)
" There was a significant shift to the right in the dose-response curve for RU24969 in the SCN in fluoxetine treated animals but a shift to the left for the dose-response curve for 8-OH-DPAT in the DRN."1.29Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro. ( Kruk, ZL; O'Connor, JJ, 1994)
"Pretreatment with desipramine and mianserin in combination induced the most intense 5-HT syndrome and the greatest fall in colonic temperature after injection of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT)."1.29Chronic, combined treatment with desipramine and mianserin: enhanced 5-HT1A receptor function and altered 5-HT1A/5-HT2 receptor interaction in rats. ( Lund, A; Mjellem, N, 1993)
"Daily corticosterone treatment decreased body weight and food intake."1.28Repeated corticosterone treatment attenuates behavioural and neuroendocrine responses to 8-hydroxy-2-(di-n-propylamino) tetralin in rats. ( Haleem, DJ, 1992)
"Ipsapirone treatment modified the kinetics, but not the amount of adrenaline released by stress."1.28Repeated treatment with the 5-HT1A receptor agonist, ipsapirone, does not affect 8-OH-DPAT- and stress-induced increases in plasma adrenaline levels in the rat. ( Baudrie, V; Chaouloff, F, 1991)

Research

Studies (40)

TimeframeStudies, this research(%)All Research%
pre-19904 (10.00)18.7374
1990's18 (45.00)18.2507
2000's15 (37.50)29.6817
2010's3 (7.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kalliokoski, O1
Jacobsen, KR1
Darusman, HS1
Henriksen, T1
Weimann, A1
Poulsen, HE1
Hau, J1
Abelson, KS1
Butt, I1
Hong, A1
Di, J1
Aracena, S1
Banerjee, P1
Shen, CH1
Jabeen, B1
Haleem, DJ4
Li, JX1
Koek, W1
France, CP1
Sano, Y1
Ornthanalai, VG1
Yamada, K1
Homma, C1
Suzuki, H1
Suzuki, T1
Murphy, NP1
Itohara, S1
Lifschytz, T1
Zozulinsky, P1
Eitan, R1
Landshut, G1
Ohayon, S1
Lerer, B1
Van de Kar, LD5
Raap, DK2
Battaglia, G4
Muma, NA3
Garcia, F5
DonCarlos, LL1
D'Souza, DN2
Zhang, Y2
Bishop, C1
Parker, GC1
Coscina, DV2
Czyrak, A1
Maćkowiak, M1
Chocyk, A1
Fijał, K1
Gadek-Michalska, A1
Wedzony, K1
Gur, E1
Newman, ME1
Avraham, Y1
Dremencov, E1
Berry, EM1
Gogos, A1
Van den Buuse, M1
Grippo, AJ1
Sullivan, NR1
Damjanoska, KJ1
Crane, JW1
Carrasco, GA1
Shi, J1
Chen, Z1
de Jong, TR1
Snaphaan, LJ1
Pattij, T1
Veening, JG1
Waldinger, MD1
Cools, AR1
Olivier, B1
Piper, BJ1
Vu, HL1
Safain, MG1
Oliver, AJ1
Meyer, JS1
Samad, N1
Flügge, G1
McBlane, JW1
Handley, SL1
Chaouloff, F3
O'Connor, JJ1
Kruk, ZL1
Jhanwar-Uniyal, M1
Moorjani, B1
Kahn, AH1
Fletcher, PJ1
Currie, PJ1
Chambers, JW1
Tejani-Butt, SM1
Yang, J1
Kaviani, A1
Lund, A1
Mjellem, N1
Invernizzi, R1
Bramante, M1
Samanin, R1
Evans, S1
Li, Q1
Wolf, WA1
Moreau, X1
Jeanningros, R1
Mazzola-Pomietto, P1
Fanelli, RJ1
McMonagle-Strucko, K1
Schechter, LE1
Bolaños, FJ1
Gozlan, H1
Lanfumey, L1
Haj-Dahmane, S1
Laporte, AM1
Fattaccini, CM1
Hamon, M1
Blanc, J1
Baudrie, V2
Laude, D1
Elghozi, JL1
Spear, LP1
Frambes, NA1
Goodwin, G1
Gulati, A1
Bhargava, HN1
Bagdy, G1
Calogero, AE1
Aulakh, CS3
Szemeredi, K1
Murphy, DL3
Gilbert, F1
Dourish, CT1
Brazell, C1
McClue, S1
Stahl, SM1
Wang, P1
Hill, JL2

Other Studies

40 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Body Weight

ArticleYear
Mice do not habituate to metabolism cage housing--a three week study of male BALB/c mice.
    PloS one, 2013, Volume: 8, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biomarkers; Body Weight; Eating; Housing, Animal; M

2013
The effects of serotonin1A receptor on female mice body weight and food intake are associated with the differential expression of hypothalamic neuropeptides and the GABAA receptor.
    Neuropeptides, 2014, Volume: 48, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anorexia Nervosa; Body Weight; Bulimia Nervosa; Fee

2014
Desensitization of pre and post synaptic 5-HT-1A receptor responses following long term consumption of sugar rich diet: implications for sugar-induced obesity.
    Pakistan journal of pharmaceutical sciences, 2008, Volume: 21, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Brain; Dietary Sucro

2008
Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats.
    European journal of pharmacology, 2009, Jun-24, Volume: 613, Issue:1-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Diet; DOM 2,5-Dimeth

2009
X11-like protein deficiency is associated with impaired conflict resolution in mice.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, May-06, Volume: 29, Issue:18

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Analysis of Variance; Animals; An

2009
Effect of triiodothyronine on antidepressant screening tests in mice and on presynaptic 5-HT1A receptors: mediation by thyroid hormone α receptors.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amiodarone; Animals; Antidepressive Agents; Body Weight; Dos

2011
Treatment of cycling female rats with fluoxetine induces desensitization of hypothalamic 5-HT(1A) receptors with no change in 5-HT(2A) receptors.
    Neuropharmacology, 2002, Volume: 43, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Second

2002
Destruction of serotonergic nerve terminals prevents fluoxetine-induced desensitization of hypothalamic 5-HT(1A) receptors.
    Psychopharmacology, 2002, Volume: 164, Issue:4

    Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animal

2002
Nicotine and its withdrawal modify dorsal raphe 8-hydroxy-2-(di-n-propylamino) tetralin feeding.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 74, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Eating; Feeding Behavior; Female; Nico

2003
8-OHDPAT-induced disruption of prepulse inhibition in rats is attenuated by prolonged corticosterone treatment.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2003, Volume: 28, Issue:7

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Glands; Animals; Anti-Inflammatory Agents; Autoradio

2003
The differential effects of food restriction on 5-HT1A and 5-HT1B receptor mediated control of serotonergic transmission in the hippocampus and hypothalamus of rats.
    Nutritional neuroscience, 2003, Volume: 6, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Female; Hippocampus; Hypothalamus; Oxa

2003
Fluoxetine-induced changes in body weight and 5-HT1A receptor-mediated hormone secretion in rats on a tryptophan-deficient diet.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2004, Volume: 286, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Body Weight; Brain; Co

2004
Estrogen and progesterone prevent disruption of prepulse inhibition by the serotonin-1A receptor agonist 8-hydroxy-2-dipropylaminotetralin.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Drug Interactions; Estrogens; Female;

2004
Chronic mild stress induces behavioral and physiological changes, and may alter serotonin 1A receptor function, in male and cycling female rats.
    Psychopharmacology, 2005, Volume: 179, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Chronic Disease; Drinking; Estrous Cyc

2005
Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2006, Volume: 16, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Analysis of Variance; Animals; Behavio

2006
Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 317, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Body Weight; Dose-Response

2006
Serotonin-1A receptor responsiveness in stress and following adaptation to stress.
    Pakistan journal of pharmaceutical sciences, 2007, Volume: 20, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Animals; Anxiety; Behavior, Anima

2007
Dynamics of central nervous 5-HT1A-receptors under psychosocial stress.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding Sites; Body Weight; Brain;

1995
Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT.
    Psychopharmacology, 1994, Volume: 116, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Body Weight; Brain Chemi

1994
Effects of repeated 2-deoxy-D-glucose administration on ingestive, psychological, and 5-HT-related behaviours in the rat.
    Neuropharmacology, 1994, Volume: 33, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Medulla; Animals; Behavior, Animal; Body Weight; Deo

1994
Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studied using fast cyclic voltammetry in vitro.
    Brain research, 1994, Mar-21, Volume: 640, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Electric Stimulation

1994
Indications of pre- and post-synaptic 5-HT1A receptor interactions in feeding behavior and neuroendocrine regulation.
    Brain research, 1994, May-23, Volume: 646, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Glucose; Body Weight; Dietary Carbohydrates;

1994
Radiofrequency lesions of the PVN fail to modify the effects of serotonergic drugs on food intake.
    Brain research, 1993, Dec-10, Volume: 630, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Clonidine; Feeding Behavior; Fenfluram

1993
Time course of altered thyroid states on 5-HT1A receptors and 5-HT uptake sites in rat brain: an autoradiographic analysis.
    Neuroendocrinology, 1993, Volume: 57, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Body Weight; Brain Chemistry; Hype

1993
Chronic, combined treatment with desipramine and mianserin: enhanced 5-HT1A receptor function and altered 5-HT1A/5-HT2 receptor interaction in rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal; Body Temperature; B

1993
Role of 5-HT1A receptors in the effects of acute chronic fluoxetine on extracellular serotonin in the frontal cortex.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 54, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Extracellular Space; Fluoxetine; Front

1996
Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Cytosol; Dose-Response Relationship, D

1999
Attenuation of 8-OH-DPAT-induced decreases in 5-Ht synthesis in brain regions of rats adapted to a repeated stress schedule.
    Stress (Amsterdam, Netherlands), 1999, Volume: 3, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Animals; Body Weight; Brain; Eati

1999
Chronic effects of triiodothyronine in combination with imipramine on 5-HT transporter, 5-HT(1A) and 5-HT(2A) receptors in adult rat brain.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2001, Volume: 24, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Tricyclic; Body Weight; Brai

2001
Alteration of 5-HT1A receptor binding sites following chronic treatment with ipsapirone measured by quantitative autoradiography.
    Synapse (New York, N.Y.), 1992, Volume: 12, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Autoradiography; Body Weight;

1992
Repeated corticosterone treatment attenuates behavioural and neuroendocrine responses to 8-hydroxy-2-(di-n-propylamino) tetralin in rats.
    Life sciences, 1992, Volume: 51, Issue:23

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Brain; Corticosteron

1992
Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenyly

1990
Cardiovascular and adrenaline-releasing effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin in streptozotocin diabetic rats.
    Life sciences, 1991, Volume: 48, Issue:26

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Glucose; Blood Pressure; Body Weight; Cortico

1991
Repeated treatment with the 5-HT1A receptor agonist, ipsapirone, does not affect 8-OH-DPAT- and stress-induced increases in plasma adrenaline levels in the rat.
    European journal of pharmacology, 1991, Jun-06, Volume: 198, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Blood Glucose; Body Weight; Chromatography, High Pr

1991
Low doses of the 5-HT1A receptor agonist 8-OH-DPAT increase ingestive behavior in late preweanling and postweanling, but not neonatal rat pups.
    European journal of pharmacology, 1991, Oct-02, Volume: 203, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Animals, Suckling; Body We

1991
Down-regulation of hypothalamic 5-HT1A receptors in morphine-abstinent rats.
    European journal of pharmacology, 1990, Jul-03, Volume: 182, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Down-Regulation; Hyp

1990
Long-term cortisol treatment impairs behavioral and neuroendocrine responses to 5-HT1 agonists in the rat.
    Neuroendocrinology, 1989, Volume: 50, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Body Weight; Catechola

1989
Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats.
    Psychoneuroendocrinology, 1988, Volume: 13, Issue:6

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; B

1988
Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists.
    Psychopharmacology, 1988, Volume: 94, Issue:4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Eating; Fenfluramine; Male; Naphthalen

1988
A comparison of feeding and locomotion responses to serotonin agonists in three rat strains.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 31, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Body Weight; Buspirone; Dose-Resp

1988