8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Bladder, Overactive in 2 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we analyzed the occupancy of 5-HT1A receptors in living Sprague-Dawley rat brains by a novel candidate drug for OAB, E2110, using positron emission tomography (PET) imaging, and assessed the utility of a receptor occupancy (RO) assay to establish a pharmacodynamic index translatable between animals and humans." | 1.39 | A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder. ( Higuchi, M; Ishihara, H; Maeda, J; Nakatani, Y; Sakai, M; Suhara, T; Suzuki, M; Takenaka, O; Tokunaga, M; Yoshinaga, T; Zhang, MR, 2013) |
| "Bladder outlet obstruction was induced in adult female rats, hypertropic bladders were harvested after 6 weeks and isometric contractions of bladder strips were recorded." | 1.34 | Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats. ( Chugh, A; Malhotra, S; Mittra, S; Naruganahalli, KS, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakatani, Y | 1 |
| Suzuki, M | 1 |
| Tokunaga, M | 1 |
| Maeda, J | 1 |
| Sakai, M | 1 |
| Ishihara, H | 1 |
| Yoshinaga, T | 1 |
| Takenaka, O | 1 |
| Zhang, MR | 1 |
| Suhara, T | 1 |
| Higuchi, M | 1 |
| Mittra, S | 1 |
| Malhotra, S | 1 |
| Naruganahalli, KS | 1 |
| Chugh, A | 1 |
2 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Bladder, Overactive
| Article | Year |
|---|---|
A small-animal pharmacokinetic/pharmacodynamic PET study of central serotonin 1A receptor occupancy by a potential therapeutic agent for overactive bladder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Oral; Animals; Computer Simulation; Hippocam | 2013 |
Role of peripheral 5-HT1A receptors in detrusor over activity associated with partial bladder outlet obstruction in female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Dose-Response Relatio | 2007 |