8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Aura in 11 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 6 (54.55) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Tokarski, K | 1 |
| Zahorodna, A | 1 |
| Bobula, B | 1 |
| Hess, G | 1 |
| Salgado, D | 1 |
| Alkadhi, KA | 2 |
| Statnick, MA | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Browning, RA | 1 |
| Salgado-Commissariat, D | 1 |
| Lu, KT | 1 |
| Gean, PW | 1 |
| Filakovszky, J | 1 |
| Kantor, S | 1 |
| Halasz, P | 1 |
| Bagdy, G | 1 |
| Nakamura, M | 1 |
| Wada, Y | 1 |
| Hasegawa, H | 1 |
| Yamaguchi, N | 1 |
| Thompson, PM | 1 |
| Zebrowski, G | 1 |
| Neuman, RS | 1 |
| Janusz, W | 1 |
| Kleinrok, Z | 1 |
| Löscher, W | 1 |
| Czuczwar, SJ | 1 |
11 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Aura
| Article | Year |
|---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Comparison of the effects of 5-HT1A and 5-HT4 receptor activation on field potentials and epileptiform activity in rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic | 2002 |
Inhibition of epileptiform activity by serotonin in rat CA1 neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Electric Stimulation; Epilepsy; Evoked | 1995 |
Abnormalities in 5-HT1A and 5-HT1B receptor binding in severe-seizure genetically epilepsy-prone rats (GEPR-9s).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Dose-Response Relationship, D | 1996 |
Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Bicuculline; Convulsants; Drug Evaluation, Preclini | 1996 |
Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Epilepsy; Excitatory Postsynaptic Potential | 1998 |
8-OH-DPAT and MK-801 affect epileptic activity independently of vigilance.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Attention; Behavior, Animal; Dizocilpine Maleate; E | 2001 |
Serotonergic mechanism in hippocampal kindled seizures.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain; Cats; | 1992 |
Alteration of neocortical activity in response to noxious stimulation: participation of the dorsal raphe.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Baclofen; Cerebral Cortex; Cortical Synchronization | 1991 |
The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Epilepsy; Male; M | 1989 |
Evaluation of the 5-hydroxytryptamine receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin in different rodent models of epilepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Convulsants; Disease Models, Anima | 1985 |