8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Anxiety in 109 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 7.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| " The opiate antagonist naloxone (1 mg/kg and 10 mg/kg) neither blocked this open arm-induced antinociception (OAIA) nor modified indices of anxiety in EPM." | 7.70 | Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam. ( Canto-de-Souza, A; da-Costa, M; Fornari, RV; Graeff, FG; Nunes-de-Souza, RL; Pelá, IR, 2000) |
| " Kainic acid in the dorsal raphe caudal subnucleus increased anxiety, but also impaired escape expression in the elevated T-maze." | 3.96 | Serotonin 2C receptors in the basolateral amygdala mediate the anxiogenic effect caused by serotonergic activation of the dorsal raphe dorsomedial subnucleus. ( Corrêa, FM; Fortaleza, EA; Matthiesen, M; Mendes, LD; Spiacci, A; Zangrossi, H, 2020) |
| " The present study sought to determine the impact of stressor controllability and the dorsal raphé nucleus (DRN) on sucrose preference and juvenile social exploration, putative measures of anhedonia and anxiety that are commonly used in studies of stress per se." | 3.74 | The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. ( Christianson, JP; Irani, M; Kubala, KH; Maier, SF; Paul, ED; Thompson, BM; Watkins, LR; Yirmiya, R, 2008) |
| "This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)." | 3.73 | Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents. ( Estrada-Camarena, E; Hernandez-Aragon, A; Picazo, O, 2006) |
| "Fluoxetine, a selective serotonin reuptake inhibitor, shows moderate efficacy and potency in the rat forced swimming depression test and the shock-induced ultrasonic vocalization anxiety test, whereas the 5-HT(1A) receptor agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) is highly efficient and potent in both models." | 3.72 | 5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat. ( Dalmus, M; De Vry, J; Jentzsch, KR; Melon, C; Schreiber, R, 2004) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 3.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| "The effects of intra-amygdala injection of midazolam (20 nmol) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 8 and 16 nmol) were investigated in rats submitted to the elevated T-maze, a new animal model of anxiety." | 3.70 | Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze. ( Graeff, FG; Viana, MB; Zangrossi, H, 1999) |
| " The opiate antagonist naloxone (1 mg/kg and 10 mg/kg) neither blocked this open arm-induced antinociception (OAIA) nor modified indices of anxiety in EPM." | 3.70 | Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam. ( Canto-de-Souza, A; da-Costa, M; Fornari, RV; Graeff, FG; Nunes-de-Souza, RL; Pelá, IR, 2000) |
| "The purpose of the present study was to determine the role of the 5-HT1A receptors in the lateral septum in the mediation of the anxiogenic effects of nicotine in the social interaction and elevated plus maze tests of anxiety in the rat." | 3.70 | The role of 5-HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration. ( Cheeta, S; File, SE; Kenny, PJ, 2000) |
| "The behavioural response of rats in the high light unfamiliar condition of the social interaction test of anxiety was observed following direct administration of the 5-HT1A receptor agonist, (+/-)-8-hydroxy-dipropylaminotetralin (8-OH-DPAT, 50, 100 or 200 ng) or antagonist tertatolol (3 micrograms) into the median raphe nucleus or dorsal hippocampus." | 3.69 | 5-HT1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively. ( Andrews, N; File, SE; Gonzalez, LE; Hogg, S, 1994) |
| "The present study determined the effect of pretreatment with "silent" selective 5-HT1A receptor antagonists on cholecystokinin (CCK)-mediated effects on rat behaviour in the elevated x-maze model of anxiety." | 3.69 | Attenuation of CCK-induced aversion in rats on the elevated x-maze by the selective 5-HT1A receptor antagonists (+) WAY100135 and WAY100635. ( Bickerdike, MJ; Fletcher, A; Marsden, CA, 1995) |
| "The response of rats naive to, or experienced with, the elevated plus-maze test of anxiety was observed following direct administration of the 5-HT1A-receptor agonist (+/-)-8-hydroxy-dipropylaminotetralin (8-OH-DPAT) (50, 100, or 200 ng) or antagonist tertatolol (3 micrograms) into the dorsal raphé nucleus or bilaterally into the ventral hippocampus." | 3.69 | Anxiolytic effects in the plus-maze of 5-HT1A-receptor ligands in dorsal raphé and ventral hippocampus. ( File, SE; Gonzalez, LE, 1996) |
| "The escape behaviour induced in rats by injecting D,L-homocysteic acid (DHL) into the dorsal periaqueductal grey area (DPAG) was used as an animal model of panic attacks to investigate the effect of imipramine, a drug used for the treatment of panic disorder, on the sensitivity of 5-HT1A receptors in the DPAG." | 3.69 | Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats. ( Marsden, CA; Mongeau, R, 1997) |
| "Targeting serotonin (5-HT) bioavailability with selective 5-HT reuptake inhibitors (SSRIs) remains the most widely used treatment for mood disorders." | 1.40 | Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis. ( Fisher, RA; Maity, B; Meng, F; Stewart, A; Wemmie, JA; Wu, Q; Wunsch, AM, 2014) |
| "The present work was aimed at a comparative investigation of the effects of chronic administration of the 5-HT1A receptor agonist 8-OH-DPAT (0." | 1.38 | [Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions]. ( Fedotova, IuO; Ordian, NÉ; Pivina, SG, 2012) |
| " The chronic administration of m-CPP at the estrous phase produced an anxiolytic effect, while at the proestrous phase, the same drug produced an anxiogenic effect." | 1.37 | [Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats]. ( Fedotova, IuO, 2011) |
| "Aripiprazole is a first next-generation atypical antipsychotic drug with dopamine system stabilizing, serotonin (5-hydroxytryptamine, 5-HT) 5-HT1A receptor partial agonistic, and 5-HT2A receptor antagonistic properties." | 1.35 | Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms. ( Abe, M; Egashira, N; Fujiwara, M; Iwasaki, K; Matsushita, M; Mishima, K; Nishimura, R; Oishi, R; Okuno, R, 2008) |
| "), given 60 min before the test, exhibited a dose-response anxiolytic effect evaluated in terms of increase in the percentage of total entries and time spent in the open and decrease of total entries and time spent in the closed arms." | 1.34 | 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. ( Braida, D; Limonta, V; Malabarba, L; Sala, M; Zani, A, 2007) |
| " The influence of chronic administration of 5-HT1A receptor agonist 8-OH-DPAT (0." | 1.32 | Effects of 5-HT1A receptor agonist and antagonist on anxiety in intact and ovariectomized female rats. ( Fedotova, JO; Hartmann, G; Lénárd, L; Sapronov, NS, 2004) |
| "Treatment with paroxetine (0." | 1.31 | 8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze. ( Abramov, U; Beljajev, S; Bourin, M; Kõks, S; Koovit, I; Vasar, E, 2001) |
| " However, at a specific dosage and acting on postsynaptic receptors of the medial septal area, 8-OH-DPAT can increase anxiety." | 1.30 | 8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats. ( Charchat, H; De Almeida, RM; Giovenardi, M; Lucion, AB, 1998) |
| "The treatment with alnespirone did not modify baseline 5-HText but significantly attenuated the ability of 0." | 1.30 | Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. ( Artigas, F; Casanovas, JM; Mengod, G; Vilaró, MT, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 38 (34.86) | 18.2507 |
| 2000's | 39 (35.78) | 29.6817 |
| 2010's | 28 (25.69) | 24.3611 |
| 2020's | 4 (3.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kurita, JPF | 1 |
| Leão, AHFF | 1 |
| Bioni, VS | 1 |
| Wuo-Silva, R | 1 |
| Lima, AC | 1 |
| Paiva-Santos, MA | 1 |
| Marinho, GF | 1 |
| Cunha, DMG | 1 |
| Becegato, M | 1 |
| Lopes-Silva, LB | 1 |
| Ribeiro, AM | 1 |
| Silva, RH | 1 |
| Matthiesen, M | 1 |
| Mendes, LD | 1 |
| Spiacci, A | 1 |
| Fortaleza, EA | 1 |
| Corrêa, FM | 1 |
| Zangrossi, H | 7 |
| Rombolà, L | 1 |
| Scuteri, D | 1 |
| Watanabe, C | 1 |
| Sakurada, S | 1 |
| Hamamura, K | 1 |
| Sakurada, T | 1 |
| Tonin, P | 1 |
| Corasaniti, MT | 1 |
| Bagetta, G | 1 |
| Morrone, LA | 1 |
| Schönfeld, LM | 1 |
| Schäble, S | 1 |
| Zech, MP | 1 |
| Kalenscher, T | 1 |
| Cai, CY | 1 |
| Wu, HY | 1 |
| Luo, CX | 1 |
| Zhu, DY | 1 |
| Zhang, Y | 1 |
| Zhou, QG | 1 |
| Zhang, J | 1 |
| Strauss, CV | 1 |
| Vicente, MA | 2 |
| Fuss, J | 1 |
| Vogt, MA | 1 |
| Weber, KJ | 1 |
| Burke, TF | 1 |
| Gass, P | 1 |
| Hensler, JG | 1 |
| Quesseveur, G | 1 |
| David, DJ | 1 |
| Gaillard, MC | 1 |
| Pla, P | 1 |
| Wu, MV | 1 |
| Nguyen, HT | 1 |
| Nicolas, V | 1 |
| Auregan, G | 1 |
| David, I | 1 |
| Dranovsky, A | 2 |
| Hantraye, P | 1 |
| Hen, R | 2 |
| Gardier, AM | 1 |
| Déglon, N | 1 |
| Guiard, BP | 1 |
| Audero, E | 1 |
| Mlinar, B | 1 |
| Baccini, G | 1 |
| Skachokova, ZK | 1 |
| Corradetti, R | 1 |
| Gross, C | 2 |
| Arrant, AE | 1 |
| Coburn, E | 1 |
| Jacobsen, J | 1 |
| Kuhn, CM | 1 |
| Brandewiede, J | 1 |
| Jakovcevski, M | 1 |
| Stork, O | 2 |
| Schachner, M | 2 |
| Stewart, A | 1 |
| Maity, B | 1 |
| Wunsch, AM | 1 |
| Meng, F | 1 |
| Wu, Q | 1 |
| Wemmie, JA | 1 |
| Fisher, RA | 1 |
| Ferreira, R | 2 |
| Nobre, MJ | 2 |
| Mosienko, V | 1 |
| Matthes, S | 1 |
| Hirth, N | 1 |
| Beis, D | 1 |
| Flinders, M | 1 |
| Bader, M | 1 |
| Hansson, AC | 1 |
| Alenina, N | 1 |
| Hui, YP | 1 |
| Wang, T | 1 |
| Han, LN | 1 |
| Li, LB | 1 |
| Sun, YN | 1 |
| Liu, J | 1 |
| Qiao, HF | 1 |
| Zhang, QJ | 1 |
| Wauson, SE | 1 |
| Sarkodie, K | 1 |
| Schuette, LM | 1 |
| Currie, PJ | 1 |
| Garcia-Garcia, AL | 1 |
| Meng, Q | 1 |
| Richardson-Jones, J | 1 |
| Leonardo, ED | 1 |
| de Paula, BB | 1 |
| Leite-Panissi, CR | 1 |
| Mitchell, E | 1 |
| Klein, SL | 1 |
| Argyropoulos, KV | 1 |
| Sharma, A | 1 |
| Chan, RB | 1 |
| Toth, JG | 1 |
| Barboza, L | 1 |
| Bavley, C | 1 |
| Bortolozzi, A | 1 |
| Chen, Q | 1 |
| Liu, B | 1 |
| Ingenito, J | 1 |
| Mark, W | 1 |
| Dudakov, J | 1 |
| Gross, S | 1 |
| Di Paolo, G | 1 |
| Artigas, F | 2 |
| van den Brink, M | 1 |
| Toth, M | 1 |
| Brandão, ML | 1 |
| Luckhart, C | 1 |
| Philippe, TJ | 1 |
| Le François, B | 1 |
| Vahid-Ansari, F | 1 |
| Geddes, SD | 1 |
| Béïque, JC | 1 |
| Lagace, DC | 1 |
| Daigle, M | 1 |
| Albert, PR | 1 |
| Amigó, J | 1 |
| Díaz, A | 1 |
| Pilar-Cuéllar, F | 1 |
| Vidal, R | 1 |
| Martín, A | 1 |
| Compan, V | 1 |
| Pazos, A | 1 |
| Castro, E | 1 |
| Christianson, JP | 2 |
| Paul, ED | 2 |
| Irani, M | 1 |
| Thompson, BM | 1 |
| Kubala, KH | 1 |
| Yirmiya, R | 1 |
| Watkins, LR | 2 |
| Maier, SF | 2 |
| Egashira, N | 1 |
| Okuno, R | 1 |
| Matsushita, M | 1 |
| Abe, M | 1 |
| Mishima, K | 1 |
| Iwasaki, K | 1 |
| Nishimura, R | 1 |
| Oishi, R | 1 |
| Fujiwara, M | 1 |
| Moraes, CL | 1 |
| Bertoglio, LJ | 1 |
| Carobrez, AP | 1 |
| dos Santos, L | 3 |
| de Macedo, CE | 1 |
| Andrade, TG | 2 |
| Briones-Aranda, A | 2 |
| Castillo-Salazar, M | 1 |
| Picazo, O | 3 |
| Lambás-Señas, L | 1 |
| Mnie-Filali, O | 1 |
| Certin, V | 1 |
| Faure, C | 1 |
| Lemoine, L | 1 |
| Zimmer, L | 1 |
| Haddjeri, N | 1 |
| Sano, Y | 1 |
| Ornthanalai, VG | 1 |
| Yamada, K | 1 |
| Homma, C | 1 |
| Suzuki, H | 1 |
| Suzuki, T | 1 |
| Murphy, NP | 1 |
| Itohara, S | 1 |
| Vianna, DM | 1 |
| Carrive, P | 1 |
| Gomes, KS | 1 |
| Nunes-De-Souza, RL | 3 |
| Clément, Y | 1 |
| Le Guisquet, AM | 1 |
| Venault, P | 1 |
| Chapouthier, G | 1 |
| Belzung, C | 1 |
| Ragole, T | 1 |
| Amat, J | 1 |
| Greenwood, BN | 1 |
| Strong, PV | 1 |
| Fleshner, M | 1 |
| Mombereau, C | 1 |
| Gur, TL | 1 |
| Onksen, J | 1 |
| Blendy, JA | 1 |
| Paterson, NE | 1 |
| Hanania, T | 1 |
| Rogel-Salazar, G | 1 |
| López-Rubalcava, C | 4 |
| Fedotova, IuO | 2 |
| Solati, J | 1 |
| Salari, AA | 1 |
| Bakhtiari, A | 1 |
| Haleem, DJ | 2 |
| Lifschytz, T | 1 |
| Broner, EC | 1 |
| Zozulinsky, P | 1 |
| Slonimsky, A | 1 |
| Eitan, R | 1 |
| Greenbaum, L | 1 |
| Lerer, B | 1 |
| Pivina, SG | 1 |
| Ordian, NÉ | 1 |
| Renoir, T | 1 |
| Pang, TY | 1 |
| Mo, C | 1 |
| Chan, G | 1 |
| Chevarin, C | 1 |
| Lanfumey, L | 1 |
| Hannan, AJ | 1 |
| Sena, LM | 1 |
| Bueno, C | 1 |
| Pobbe, RL | 1 |
| Viana, MB | 2 |
| Kagamiishi, Y | 1 |
| Yamamoto, T | 1 |
| Watanabe, S | 1 |
| Carvalho-Netto, EF | 1 |
| De Vry, J | 2 |
| Schreiber, R | 1 |
| Melon, C | 1 |
| Dalmus, M | 1 |
| Jentzsch, KR | 1 |
| de Andrade, TG | 2 |
| Bert, B | 1 |
| Felicio, LF | 1 |
| Fink, H | 2 |
| Nasello, AG | 1 |
| Sokal, DM | 1 |
| Giarola, AS | 1 |
| Large, CH | 1 |
| Zanoveli, JM | 1 |
| Nogueira, RL | 1 |
| Estrada-Camarena, E | 1 |
| Hernandez-Aragon, A | 1 |
| Hofmann, CE | 1 |
| Patyk, IA | 1 |
| Weinberg, J | 1 |
| Fedotova, JO | 1 |
| Hartmann, G | 1 |
| Lénárd, L | 1 |
| Sapronov, NS | 1 |
| Braida, D | 1 |
| Limonta, V | 1 |
| Malabarba, L | 1 |
| Zani, A | 1 |
| Sala, M | 1 |
| Zajdel, P | 1 |
| Subra, G | 1 |
| Bojarski, AJ | 1 |
| Duszyńska, B | 1 |
| Tatarczyńska, E | 1 |
| Nikiforuk, A | 1 |
| Chojnacka-Wójcik, E | 1 |
| Pawłowski, M | 1 |
| Martinez, J | 1 |
| Samad, N | 1 |
| Tsetsenis, T | 1 |
| Ma, XH | 1 |
| Lo Iacono, L | 1 |
| Beck, SG | 1 |
| van den Buuse, M | 1 |
| Martin, S | 1 |
| Holgate, J | 1 |
| Matthaei, K | 1 |
| Hendry, I | 1 |
| Zangrossi Junior, H | 1 |
| Koenig, J | 1 |
| Cosquer, B | 1 |
| Cassel, JC | 2 |
| McBlane, JW | 2 |
| Handley, SL | 2 |
| Andrews, N | 2 |
| Hogg, S | 1 |
| Gonzalez, LE | 5 |
| File, SE | 6 |
| Naito, H | 1 |
| Arishima, K | 1 |
| Tonoue, T | 1 |
| Shimada, T | 1 |
| Matsumoto, K | 1 |
| Osanai, M | 1 |
| Matsuda, H | 1 |
| Terasawa, K | 1 |
| Watanabe, H | 1 |
| Chaouloff, F | 2 |
| Shepherd, JK | 3 |
| Grewal, SS | 2 |
| Fletcher, A | 3 |
| Bill, DJ | 2 |
| Dourish, CT | 2 |
| Belcheva, I | 1 |
| Belcheva, S | 1 |
| Petkov, VV | 1 |
| Petkov, VD | 1 |
| Klint, T | 1 |
| Andersson, G | 1 |
| Bickerdike, MJ | 1 |
| Marsden, CA | 3 |
| González, MI | 1 |
| Albonetti, E | 1 |
| Siddiqui, A | 1 |
| Farabollini, F | 1 |
| Wilson, CA | 1 |
| Bilkei-Gorzó, A | 1 |
| Gyertyán, I | 1 |
| Szabados, T | 1 |
| Kulikov, A | 1 |
| Aguerre, S | 1 |
| Berton, O | 1 |
| Ramos, A | 1 |
| Mormede, P | 1 |
| Rex, A | 1 |
| Mongeau, R | 1 |
| Collinson, N | 1 |
| Dawson, GR | 1 |
| Overstreet, DH | 2 |
| Fernández-Guasti, A | 1 |
| Ogren, SO | 1 |
| Misane, I | 1 |
| De Almeida, RM | 1 |
| Giovenardi, M | 1 |
| Charchat, H | 1 |
| Lucion, AB | 1 |
| Casanovas, JM | 1 |
| Vilaró, MT | 1 |
| Mengod, G | 1 |
| Menard, J | 1 |
| Treit, D | 1 |
| McGrath, C | 1 |
| Norman, TR | 1 |
| Ouagazzal, AM | 1 |
| Graeff, FG | 2 |
| Welzl, H | 1 |
| Wotjak, CT | 1 |
| Hoyer, D | 1 |
| Delling, M | 1 |
| Cremer, H | 1 |
| Heslop, KE | 1 |
| Curzon, G | 1 |
| Micheau, J | 1 |
| Van Marrewijk, B | 1 |
| Bertrand, F | 1 |
| Lehmann, O | 1 |
| Lazarus, C | 1 |
| Jeltsch, H | 1 |
| Cervo, L | 1 |
| Mocaër, E | 1 |
| Bertaglia, A | 1 |
| Samanin, R | 1 |
| Canto-de-Souza, A | 1 |
| da-Costa, M | 1 |
| Fornari, RV | 1 |
| Pelá, IR | 1 |
| Duxon, MS | 1 |
| Starr, KR | 1 |
| Upton, N | 1 |
| Cheeta, S | 1 |
| Kenny, PJ | 1 |
| Santarelli, L | 1 |
| Gobbi, G | 1 |
| Debs, PC | 1 |
| Sibille, ET | 1 |
| Blier, P | 1 |
| Heath, MJ | 1 |
| Kõks, S | 1 |
| Beljajev, S | 1 |
| Koovit, I | 1 |
| Abramov, U | 1 |
| Bourin, M | 1 |
| Vasar, E | 1 |
| Nakamura, K | 1 |
| Kurasawa, M | 1 |
| Harkany, T | 1 |
| O'Mahony, S | 1 |
| Keijser, J | 1 |
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| Borostyánkoi, ZA | 1 |
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| Vaarmann, A | 1 |
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| Allikmets, L | 1 |
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| Jones, BJ | 1 |
| Oakley, NR | 1 |
| Kostowski, W | 1 |
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| Krzascik, P | 1 |
| Järbe, T | 1 |
| Archer, T | 1 |
| Blanchard, DC | 1 |
| Rodgers, RJ | 1 |
| Blanchard, RJ | 1 |
| Kennett, GA | 1 |
| Moser, PC | 1 |
| Tricklebank, MD | 1 |
| Middlemiss, DN | 1 |
| Mir, AK | 1 |
| Hibert, MF | 1 |
| Fozard, JR | 1 |
3 reviews available for 8-hydroxy-2-(di-n-propylamino)tetralin and Anxiety
| Article | Year |
|---|---|
Serotonin mechanisms in animal models of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Disease Mo | 1993 |
5-HT1A receptor agonists: recent developments and controversial issues.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Depression; Humans; Serotonin; Serotonin R | 1995 |
Mechanisms of serotonergic affect control.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Busp | 1991 |
106 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Anxiety
| Article | Year |
|---|---|
Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learning; Basolateral Nuclear Co | 2023 |
Serotonin 2C receptors in the basolateral amygdala mediate the anxiogenic effect caused by serotonergic activation of the dorsal raphe dorsomedial subnucleus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Animals; Anxiety; Basolateral Nuclear Comple | 2020 |
Role of 5-HT1A Receptor in the Anxiolytic-Relaxant Effects of Bergamot Essential Oil in Rodent.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Dis | 2020 |
5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anxiety; Behavior, Animal; Choice Behavio | 2020 |
Extracellular regulated protein kinaseis critical for the role of 5-HT1a receptor in modulating nNOS expression and anxiety-related behaviors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety; Dark Adaptation; Disease | 2019 |
Activation of 5-HT1A receptors in the rat basolateral amygdala induces both anxiolytic and antipanic-like effects.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Dark Adapta | 2013 |
Hippocampal serotonin-1A receptor function in a mouse model of anxiety induced by long-term voluntary wheel running.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Disease Models, Animal; Hippocampus; Mice; | 2013 |
BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 2013 |
Suppression of serotonin neuron firing increases aggression in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Aggression; Animals; Anxiety; Autoradiogr | 2013 |
Lower anxiogenic effects of serotonin agonists are associated with lower activation of amygdala and lateral orbital cortex in adolescent male rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Amygdala; Animals; Anxiety; Behavior, Animal; D | 2013 |
Role of stress system disturbance and enhanced novelty response in spatial learning of NCAM-deficient mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Corticosterone; Hippocampus; Hypothalamo-H | 2013 |
Regulator of G-protein signaling 6 (RGS6) promotes anxiety and depression by attenuating serotonin-mediated activation of the 5-HT(1A) receptor-adenylyl cyclase axis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Animals; Animals, Newborn; Anxiety; Cells | 2014 |
Conditioned fear in low- and high-anxious rats is differentially regulated by cortical subcortical and midbrain 5-HT(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Basolateral Nuclear Complex; Brain; Cerebr | 2014 |
Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Brain; Depression; Female; Hypothermia; Ma | 2014 |
Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Anima | 2015 |
Midbrain raphe 5-HT1A receptor activation alters the effects of ghrelin on appetite and performance in the elevated plus maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Appetite; Behavior, Animal; Dose-Response | 2015 |
Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Animals; Anxiety; Conflict, Psychological; Cort | 2016 |
Distinct effect of 5-HT1A and 5-HT2A receptors in the medial nucleus of the amygdala on tonic immobility behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Corticomedial Nuclear Complex; Fear; Guine | 2016 |
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; | 2016 |
5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Cerebral Cortex; Fear; F | 2016 |
Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Physiological; Animals; Anxiety; Behavior, Anima | 2016 |
The absence of 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anhedonia; Animals; Antidepressive Agents, Second-Generation | 2016 |
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Conditioning, Psychologi | 2008 |
Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Anxiety; Aripiprazole; Behavi | 2008 |
Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Di | 2008 |
Involvement of median raphe nucleus 5-HT1A receptors in the regulation of generalized anxiety-related defensive behaviours in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learning; Behavior, Animal; Dise | 2008 |
Adrenalectomy modifies the hippocampal 5-HT(1A) receptors and the anxiolytic-like effect of 8-OH-DPAT in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenalectomy; Animals; Anti-Anxiety Agents; Anxiety; Autora | 2009 |
Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Behavior, Animal; Brain C | 2009 |
X11-like protein deficiency is associated with impaired conflict resolution in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Analysis of Variance; Animals; An | 2009 |
Inhibition of the cardiovascular response to stress by systemic 5-HT1A activation: sympathoinhibition or anxiolysis?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Blood Pressure; Body Temperature; Cardiova | 2009 |
Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Analysis of Variance; Animals; Anxiety; Behavi | 2009 |
Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Bicucul | 2009 |
5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aminopyridines; Amygdala; Analysis of Variance; Animals; Ani | 2010 |
Differential effects of acute and repeated citalopram in mouse models of anxiety and depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 2010 |
The modified Geller-Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5-HT1A receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Conditioning, Operant; C | 2010 |
Evaluation of the anxiolytic-like effects of clomipramine in two rat strains with different anxiety vulnerability (Wistar and Wistar-Kyoto rats): participation of 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Clo | 2011 |
[Effects of 5-HT1 and 5-HT2 serotonin receptors on anxiety- and depression-like behavior in female rats].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; D | 2011 |
5HT(1A) and 5HT(1B) receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Exploratory Behavior; | 2011 |
Behavioral deficits and exaggerated feedback control over raphe-hippocampal serotonin neurotransmission in restrained rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; | 2011 |
Relationship between Rgs2 gene expression level and anxiety and depression-like behaviour in a mutant mouse model: serotonergic involvement.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety; Brain Chemistry; Dep | 2012 |
[Analysis of 8-OH-DPAT and NAN-190 effects in young prenatally stressed rats under experimental estrogen deficiency conditions].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Estrogens; Female; Male; | 2012 |
Differential effects of early environmental enrichment on emotionality related behaviours in Huntington's disease transgenic mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Depression; Disease Mode | 2013 |
Influence of forced swimming-induced stress on the anxiolytic-like effect of 5HT(1A) agents in mice.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anx | 2002 |
The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learnin | 2003 |
Hippocampal serotonergic system is involved in anxiety-like behavior induced by corticotropin-releasing factor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Corticotropin-Releasing Hormone; Dose-Resp | 2003 |
Use of the elevated T-maze to study anxiety in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; | 2004 |
5-HT1A receptors are differentially involved in the anxiolytic- and antidepressant-like effects of 8-OH-DPAT and fluoxetine in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidep | 2004 |
Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learning; Carbolines; Escape Rea | 2005 |
The use of sudden darkness in mice: a behavioural and pharmacological approach.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Darkness; Female; Male; | 2005 |
Effects of GABA(B), 5-HT(1A), and 5-HT(2) receptor stimulation on activation and inhibition of the rat lateral amygdala following medial geniculate nucleus stimulation in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Amygdala; Animals; Anxiety; Baclofen; Evoked P | 2005 |
Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Antidepressive Agents, Tricyclic; Anx | 2005 |
Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; | 2006 |
Prenatal ethanol exposure: sex differences in anxiety and anxiolytic response to a 5-HT1A agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Feeding Behavior; Female; Humans; Male; Pr | 2005 |
Effects of 5-HT1A receptor agonist and antagonist on anxiety in intact and ovariectomized female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Estradiol; Female; Ovariectomy; Piperazine | 2004 |
5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Arachidonic Acids; Dronabinol; Endocannabi | 2007 |
Novel class of arylpiperazines containing N-acylated amino acids: their synthesis, 5-HT1A, 5-HT2A receptor affinity, and in vivo pharmacological evaluation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amino Acids; Animals; Anti-Anxiety Agents; Antidepressive Ag | 2007 |
Serotonin-1A receptor responsiveness in stress and following adaptation to stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Animals; Anxiety; Behavior, Anima | 2007 |
Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anxiety; Autoradiography; Behavior, Anima | 2007 |
Mice deficient in the alpha subunit of G(z) show changes in pre-pulse inhibition, anxiety and responses to 5-HT(1A) receptor stimulation, which are strongly dependent on the genetic background.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anxiety; Exploratory Behavior | 2007 |
5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Electric Stimulation; Ex | 2008 |
Activation of septal 5-HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water-maze task.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Anesthetics, Local; Animals; Anxiety; | 2008 |
Effects of two stressors on behaviour in the elevated X-maze: preliminary investigation of their interaction with 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Body Weight; Brain Chemi | 1994 |
5-HT1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Analysis of Variance; Animals; | 1994 |
Neonatal damage to neocortex abolishes the anxiolytic action of diazepam in adult rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety; Cerebral Cortex; Diazepa | 1995 |
The modified light/dark transition test in mice: evaluation of classic and putative anxiolytic and anxiogenic drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Darkness; | 1995 |
Influence of physical exercise on 5-HT1A receptor- and anxiety-related behaviours.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Eating; Male; Physical E | 1994 |
Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chl | 1994 |
Hippocampal asymmetry in the behavioral responses to the 5-HT1A receptor agonist 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; B | 1994 |
Ultrasound vocalization is not related to corticosterone response in isolated rat pups.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Anxiety; Buspirone; Corticosteron | 1994 |
Attenuation of CCK-induced aversion in rats on the elevated x-maze by the selective 5-HT1A receptor antagonists (+) WAY100135 and WAY100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Cholecystokinin; Disease | 1995 |
Anxiolytic effects in the plus-maze of 5-HT1A-receptor ligands in dorsal raphé and ventral hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; A | 1996 |
Neonatal organizational effects of the 5-HT2 and 5-HT1A subsystems on adult behavior in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Animals, Newborn; Anxiety; Behavior, | 1996 |
Pre- or postsynaptic activity of 5-HT1A compounds in mice depends on the anxiety paradigm.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Buspirone; Disease Model | 1996 |
5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholinesterase; Adrenergic beta-Antagonists; Amygdala; | 1996 |
mCPP-induced anxiety--a potential new method for screening anxiolytic activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; | 1996 |
Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Citalopram; Female; Hipp | 1997 |
Cortical 5-HT-CCK interactions and anxiety-related behaviour of guinea-pigs: a microdialysis study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Behavior, Animal; Cerebral Cortex; Female; | 1997 |
Effect of imipramine treatments on the 5-HT1A-receptor-mediated inhibition of panic-like behaviours in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Antidepressive Agents, Tricyc | 1997 |
On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Buspirone; Exploratory Behavior; Male; Pip | 1997 |
Behavioural and pharmacological characterisation of the canopy stretched attend posture test as a model of anxiety in mice and rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chl | 1997 |
Selectively bred lines of rats differ in social interaction and hippocampal 5-HT1A receptor function: a link between anxiety and depression?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Depressive Disorder; Hippocampus; Interper | 1998 |
Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; | 1998 |
Animal models for studying serotonin (5-HT) receptor subtypes: relationship to 5-HT system pathologies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learning; Disease Models, Animal | 1998 |
8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Female; Microinjections; Raphe Nuclei; Rat | 1998 |
Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Autoradiography; Brain Chemistry; Dendrite | 1999 |
The septum and the hippocampus differentially mediate anxiolytic effects of R(+)-8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Drug Administration R | 1998 |
(+)-S-20499 -- a potential antidepressant? A behavioural and neurochemical investigation in the olfactory bulbectomised rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; | 1999 |
Chronic fluoxetine in tests of anxiety in rat lines selectively bred for differential 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents, Second-Generation; Anxiety; | 1999 |
Anxiolytic effect of intra-amygdala injection of midazolam and 8-hydroxy-2-(di-n-propylamino)tetralin in the elevated T-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents | 1999 |
Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Autoradiography; Bind | 1999 |
Effect of reserpine on behavioural responses to agonists at 5-HT1A, 5-HT1B, 5-HT2A, and 5-HT2C receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Anxiety; Behavior, Animal; Body Tempe | 1999 |
Stimulation of 5-HT1A receptors by systemic or medial septum injection induces anxiogenic-like effects and facilitates acquisition of a spatial discrimination task in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Discrimination Learning; Injections; Male; | 1999 |
Intraseptal infusions of 8-OH-DPAT in the rat impairs water-maze performances: effects on memory or anxiety?
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Cholinergic Fibers; Maze Learning; Memory; | 2000 |
Roles of 5-HT(1A) receptors in the dorsal raphe and dorsal hippocampus in anxiety assessed by the behavioral effects of 8-OH-DPAT and S 15535 in a modified Geller-Seifter conflict model.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Conditioning, Operant; Conflict, Psycholog | 2000 |
Anxiety-induced antinociception in mice: effects of systemic and intra-amygdala administration of 8-OH-DPAT and midazolam.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Analgesia; Animals; Anti-Anxiety Agents; Anxiety; | 2000 |
Latency to paroxetine-induced anxiolysis in the rat is reduced by co-administration of the 5-HT(1A) receptor antagonist WAY100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Anima | 2000 |
The role of 5-HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Drug Interactions; Male; Maze Learning; Ne | 2000 |
Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cor | 2001 |
8-OH-DPAT, but not deramciclane, antagonizes the anxiogenic-like action of paroxetine in an elevated plus-maze.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Camphanes; Exploratory Behavior; Male; Mot | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bro | 2001 |
Beta-amyloid(1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amyloid beta-Peptides; Animals; Anxiety; Basal Nucleus of Me | 2001 |
Role of 5-HT1A receptors in the mediation of acute citalopram effects: a 8-OH-DPAT challenge study.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Brain; Citalopram; Drug Synergism; Explora | 2002 |
Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychologic | 1992 |
5-Hydroxytryptamine1A receptor agonists in animal models of depression and anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Buspirone; Chromans; Depression; Disease M | 1992 |
Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense Test Battery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anxiety; Cats; Female; Male; Motor Acti | 1992 |
Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conditioni | 1990 |