8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Anesthesia in 30 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Under pentobarbital anesthesia, central administration of the selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ipsapirone decreased plasma CS levels, relative to saline-treated control rats, at all doses tested (0." | 3.68 | Central 5-HT1A receptors inhibit adrenocortical secretion. ( Dunn, AJ; Farrar, GE; Saphier, D; Welch, JE, 1993) |
| "Pretreatment with NAN 190 reduced baseline values of mean arterial pressure and prevented 8-OH-DPAT-induced hypotension." | 1.34 | Peripheral 5-HT1A receptors are not essential for increased ventilation evoked by systemic 8-OH-DPAT challenge in anaesthetized rats. ( Kaczyńska, K; Szereda-Przestaszewska, M, 2007) |
| "63 mg/kg) shifted the dose-response curve of each agonist to the right in a dose-dependent manner." | 1.31 | Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. ( Assié, MB; Koek, W, 2000) |
| " Chronic administration of idazoxan (0." | 1.28 | Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function. ( Crespi, F; Garratt, JC; Marsden, CA; Mason, R, 1991) |
| " With guanfacine the maximal fall of blood pressure was comparable to that obtained with the 5-HT1A receptor ligands; however, in contrast to the latter, the dose-response curve was U-shaped, the highest dose eliciting a pressor effect with reversal of the vasodilatation." | 1.28 | 8-OH-DPAT, flesinoxan and guanfacine: systemic and regional haemodynamic effects of centrally acting antihypertensive agents in anaesthetized rabbits. ( Fozard, JR; Hof, RP, 1989) |
| " Cumulative dose-response (i." | 1.28 | Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and alpha 2-adrenoceptor agonists in anaesthetized cats. ( Ramage, AG; Wilkinson, SJ, 1989) |
| " Cumulative dose-response curves were constructed for 8-OH-DPAT, ipsapirone and clonidine." | 1.27 | Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats. ( Fozard, JR; Ramage, AG, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (30.00) | 18.7374 |
| 1990's | 10 (33.33) | 18.2507 |
| 2000's | 11 (36.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Crespi, F | 2 |
| Oskutyte, D | 1 |
| Jordan, D | 3 |
| Ramage, AG | 7 |
| Hayes, ES | 1 |
| Adaikan, PG | 1 |
| Carro-Juárez, M | 1 |
| Cruz, SL | 1 |
| Rodríguez-Manzo, G | 1 |
| Ootsuka, Y | 1 |
| Blessing, WW | 1 |
| Querejeta, E | 1 |
| Oviedo-Chávez, A | 1 |
| Araujo-Alvarez, JM | 1 |
| Quiñones-Cárdenas, AR | 1 |
| Delgado, A | 1 |
| Rex, A | 1 |
| Fink, H | 1 |
| Szereda-Przestaszewska, M | 1 |
| Kaczyńska, K | 1 |
| Kreiss, DS | 1 |
| Wieland, S | 1 |
| Lucki, I | 1 |
| Shepheard, SL | 2 |
| Futuro-Neto, HA | 1 |
| Pires, JG | 1 |
| Gilbey, MP | 1 |
| Welch, JE | 1 |
| Farrar, GE | 1 |
| Dunn, AJ | 1 |
| Saphier, D | 1 |
| Assié, MB | 1 |
| Koek, W | 1 |
| Siddiqui, A | 1 |
| Kotecha, K | 1 |
| Salicioni, AM | 1 |
| Kalia, V | 1 |
| Murray, JF | 1 |
| Wilson, CA | 1 |
| Wang, Y | 1 |
| Perren, MJ | 1 |
| Feniuk, W | 2 |
| Humphrey, PP | 1 |
| Garratt, JC | 1 |
| Mason, R | 1 |
| Marsden, CA | 1 |
| Stubbs, CM | 1 |
| Connor, HE | 1 |
| Dreteler, GH | 1 |
| Wouters, W | 1 |
| Saxena, PR | 1 |
| Bouhelal, R | 1 |
| Loubatières-Mariani, MM | 1 |
| Mir, AK | 1 |
| Sharp, T | 2 |
| Bramwell, SR | 2 |
| Clark, D | 1 |
| Grahame-Smith, DG | 2 |
| Laubie, M | 1 |
| Drouillat, M | 1 |
| Dabiré, H | 2 |
| Cherqui, C | 2 |
| Schmitt, H | 2 |
| Docherty, JR | 1 |
| Hof, RP | 1 |
| Fozard, JR | 2 |
| Hjorth, S | 1 |
| Wilkinson, SJ | 1 |
| Fournier, B | 1 |
| Doods, HN | 1 |
| Kalkman, HO | 1 |
| De Jonge, A | 1 |
| Thoolen, MJ | 1 |
| Wilffert, B | 1 |
| Timmermans, PB | 1 |
| Van Zwieten, PA | 1 |
30 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Anesthesia
| Article | Year |
|---|---|
Apamin increases 5-HT cell firing in raphe dorsalis and extracellular 5-HT levels in amygdala: a concomitant in vivo study in anesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Amygdala; Anesthesia; Animals; Apamin; Ex | 2009 |
Evidence that 5-hydroxytryptamine(7) receptors play a role in the mediation of afferent transmission within the nucleus tractus solitarius in anaesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Afferent Pathways; Anesthesia; Animals; E | 2009 |
Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Male; Penile Erection; Penis; Piperazin | 2002 |
Evidence for the involvement of a spinal pattern generator in the control of the genital motor pattern of ejaculation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Copulation; Denervation; Ejaculation; E | 2003 |
5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically mediated cutaneous vasoconstriction in rabbits.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Body Temperature; Cold Temperature; Con | 2003 |
In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Anesthesia; Animals; Behavior, Animal; De | 2005 |
Effects of 8-OH-DPAT on hippocampal NADH fluorescence in vivo in anaesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Hippocampus; Lasers; Male; NAD; Neurons | 2006 |
Peripheral 5-HT1A receptors are not essential for increased ventilation evoked by systemic 8-OH-DPAT challenge in anaesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Male; Nodose Ganglion; | 2007 |
The presence of a serotonin uptake inhibitor alters pharmacological manipulations of serotonin release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Chromatography, High Pressure Liquid; C | 1993 |
Comparison of the effects of IVth ventricular administration of some tryptamine analogues with those of 8-OH-DPAT on autonomic outflow in the anaesthetized cat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Autonomic Nervous System; Blood Pressur | 1994 |
Evidence for the ability of central 5-HT1A receptors to modulate the vagal bradycardia induced by stimulating the upper airways of anesthetized rabbits with smoke.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Apnea; Atenolol; Blood Pressure; Buspir | 1993 |
Central 5-HT1A receptors inhibit adrenocortical secretion.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Cortex; Anesthesia; Animals; Corticosterone; Injecti | 1993 |
Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Benzamides; Buspirone; Dose-Response Re | 2000 |
Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Estradiol; Female; Luteinizing Hormone; | 2000 |
The role of central 5-HT(1A) receptors in the control of B-fibre cardiac and bronchoconstrictor vagal preganglionic neurones in anaesthetized cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Autonomic Fibers, Preganglionic; Bronch | 2001 |
Vascular 5-HT1-like receptors that mediate contraction of the dog isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized dogs are not of the 5-HT1A or 5-HT1D subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Atropine; Carotid Arteries; Dogs; Gangl | 1991 |
Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Anesthesia; Animals; Dioxanes; | 1991 |
BMY 7378 is an agonist at 5-HT1A receptors mediating hypotension and renal sympatho-inhibition in anaesthetised cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Cats; Female; Heart Rat | 1991 |
Comparison of the cardiovascular effects of the 5-HT1A receptor agonist flesinoxan with that of 8-OH-DPAT in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Antihypertensive Agents; Atropine; Bloo | 1990 |
Investigation of the mechanism(s) of 8-OH-DPAT-mediated inhibition of plasma insulin in spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Glucose; Blood Pressure; Clonidin | 1990 |
Actions of 8-OH-DPAT on sympathetic and respiratory drives, blood pressure and heart rate in the rabbit.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Anesthesia; Animals; Atropine; Blood Pres | 1990 |
In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Dialysis; Elec | 1989 |
Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (+/-)8-OH-DPAT in anaesthetized dogs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Anesthesia; Animals; Blood Pressure; C | 1989 |
An investigation of the effects of intravenous injection of the 5-hydroxytryptamine 2 receptor antagonists ketanserin and LY 53857 on blood pressure in anesthetized spontaneously hypertensive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Ergolines; Heart Rate; | 1989 |
8-OH-DPAT, flesinoxan and guanfacine: systemic and regional haemodynamic effects of centrally acting antihypertensive agents in anaesthetized rabbits.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Anesthesia; Animals; Antihypert | 1989 |
Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Anesthesia; Animals; Biogenic M | 1989 |
Evidence that different regional sympathetic outflows vary in their sensitivity to the sympathoinhibitory actions of putative 5-HT1A and alpha 2-adrenoceptor agonists in anaesthetized cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Anesthesia; Animals; Cats; Clonid | 1989 |
Evidence that the putative 5-HT1A receptor agonists, 8-OH-DPAT and ipsapirone, have a central hypotensive action that differs from that of clonidine in anaesthetised cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Antihypertensive Agents; Atropine; Bloo | 1987 |
Comparison of effects of some 5-HT1 agonists on blood pressure and heart rate of normotensive anaesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Blood Pressure; Heart Rate; Male; Metho | 1987 |
Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Anesthesia; Animals; Binding Sites; Blood Pressure; In Vitro | 1985 |