8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Alzheimer Disease in 9 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Chronic administration of lecozotan did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model indicative of 5-HT(1A) receptor function." | 1.33 | Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. ( Abou-Gharbia, M; Andree, T; Barrett, JE; Buccafusco, J; Childers, W; Dawson, LA; Harder, JA; Hoebel, B; Jones, D; Kelly, M; Marquis, K; Nawoschik, S; Piesla, M; Rada, P; Rosenzweig-Lipson, S; Schechter, LE; Smith, DL; Sukoff, SJ; Terry, AV; Womack, MD, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Li, J | 2 |
| Huang, Y | 1 |
| Gong, Q | 1 |
| Fu, Y | 1 |
| Xu, Y | 1 |
| Huang, J | 1 |
| You, H | 1 |
| Zhang, D | 2 |
| Mao, F | 1 |
| Zhu, J | 1 |
| Wang, H | 1 |
| Zhang, H | 1 |
| Lai, MK | 3 |
| Tsang, SW | 3 |
| Esiri, MM | 3 |
| Francis, PT | 3 |
| Wong, PT | 1 |
| Chen, CP | 3 |
| Keene, J | 2 |
| Hope, T | 2 |
| Spence, I | 1 |
| Schechter, LE | 1 |
| Smith, DL | 1 |
| Rosenzweig-Lipson, S | 1 |
| Sukoff, SJ | 1 |
| Dawson, LA | 1 |
| Marquis, K | 1 |
| Jones, D | 1 |
| Piesla, M | 1 |
| Andree, T | 1 |
| Nawoschik, S | 1 |
| Harder, JA | 1 |
| Womack, MD | 1 |
| Buccafusco, J | 1 |
| Terry, AV | 1 |
| Hoebel, B | 1 |
| Rada, P | 1 |
| Kelly, M | 1 |
| Abou-Gharbia, M | 1 |
| Barrett, JE | 1 |
| Childers, W | 1 |
| Weinstein, D | 1 |
| Magnuson, D | 1 |
| Lee, J | 1 |
| Andorn, AC | 1 |
| Pappolla, MA | 1 |
| O'Neill, C | 1 |
| Cowburn, RF | 1 |
| Wiehager, B | 1 |
| Alafuzoff, I | 1 |
| Winblad, B | 1 |
| Fowler, CJ | 1 |
| Middlemiss, DN | 1 |
| Palmer, AM | 1 |
| Edel, N | 1 |
| Bowen, DM | 1 |
1 trial available for 8-hydroxy-2-(di-n-propylamino)tetralin and Alzheimer Disease
| Article | Year |
|---|---|
Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Fema | 2003 |
8 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Alzheimer Disease
| Article | Year |
|---|---|
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antidepressive Agents; Binding Sites; Brain; Choli | 2022 |
Differential involvement of hippocampal serotonin1A receptors and re-uptake sites in non-cognitive behaviors of Alzheimer's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Binding | 2011 |
Postmortem serotoninergic correlates of cognitive decline in Alzheimer's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Cog | 2002 |
Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Alzheimer Disease; Animals; Callithrix; Cogni | 2005 |
Altered G-protein coupling of a frontal cortical low affinity [3H]8-hydroxy-N,N-dipropyl-2-aminotetralin serotonergic binding site in Alzheimer's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Alzheimer Disease; Female; GTP-Binding Proteins; Guany | 1996 |
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catec | 2001 |
Preservation of 5-hydroxytryptamine1A receptor-G protein interactions in the cerebral cortex of patients with Alzheimer's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Alzheimer Disease; Cerebral Cortex; Female; Frontal Lo | 1991 |
Binding of the novel serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin in normal and Alzheimer brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alzheimer Disease; Binding Sites; Brain; Cerebral Cortex; Fr | 1986 |