8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Alcohol Drinking in 16 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compares Long-Evans rats and squirrel monkeys to examine the hypothesis that low doses of the 5-HT(1A) selective agonists, 8-OH-DPAT and alnespirone, will preferentially increase, and at higher doses decrease alcohol drinking, and whether these effects can be antagonized by WAY 100635." | 3.72 | 5-HT1A agonists: alcohol drinking in rats and squirrel monkeys. ( McKenzie-Quirk, SD; Miczek, KA, 2003) |
| "[3H]sulpiride binding was significantly different only in the ventral tegmental area (VTA), where binding was approximately 20% lower in the periadolescent P rats compared with the NP rat pups." | 1.32 | Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups. ( Li, TK; Lumeng, L; McBride, WJ; Strother, WN, 2003) |
| " Further, to evaluate the functional status of the autoreceptors under control conditions and after withdrawal from chronic ethanol, the selective serotonin-1A receptor agonist 8-hydroxy-(2-di-n-propylamino)tetralin was administered intravenously in cumulative doses (1-16 microg/kg) and dose-response curves were generated for both groups." | 1.30 | Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies. ( Diana, M; Gessa, G; Muntoni, AL; Pistis, M, 1997) |
| "Spiroxatrine (4 mg/kg, IP) was without effect on ethanol intake when given alone." | 1.28 | Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. ( Li, TK; Lumeng, L; McBride, WJ; Murphy, JM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Quadros, IM | 1 |
| Hwa, LS | 1 |
| Shimamoto, A | 1 |
| Carlson, J | 1 |
| DeBold, JF | 1 |
| Miczek, KA | 2 |
| West, CH | 1 |
| Boss-Williams, KA | 1 |
| Weiss, JM | 1 |
| Strother, WN | 1 |
| Lumeng, L | 4 |
| Li, TK | 4 |
| McBride, WJ | 3 |
| McKenzie-Quirk, SD | 1 |
| Hensler, JG | 1 |
| Ladenheim, EE | 1 |
| Lyons, WE | 1 |
| Hasnat, A | 1 |
| Haider, S | 1 |
| Perveen, T | 1 |
| Kidwai, IM | 1 |
| Haleem, DJ | 1 |
| Rilke, O | 1 |
| May, T | 1 |
| Oehler, J | 1 |
| Wolffgramm, J | 1 |
| Guan, XM | 1 |
| Chernet, E | 1 |
| Tomkins, DM | 1 |
| Higgins, GA | 1 |
| Sellers, EM | 1 |
| Schreiber, R | 1 |
| Opitz, K | 1 |
| Glaser, T | 1 |
| De Vry, J | 1 |
| Wong, DT | 1 |
| Reid, LR | 1 |
| Pistis, M | 1 |
| Muntoni, AL | 1 |
| Gessa, G | 1 |
| Diana, M | 1 |
| Wilson, AW | 1 |
| Costall, B | 1 |
| Neill, JC | 1 |
| Chen, CC | 1 |
| Fujiwara, Y | 1 |
| Akiyama, K | 1 |
| Ujike, H | 1 |
| Moriya, F | 1 |
| Otsuki, S | 1 |
| Overstreet, DH | 1 |
| Rezvani, AH | 1 |
| Janowsky, DS | 1 |
| Murphy, JM | 1 |
16 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Alcohol Drinking
| Article | Year |
|---|---|
Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Alcohol Drinking; Animals; Central Nervous Syste | 2014 |
Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Antidepressive Agents, Second-Gen | 2011 |
Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Alcohol Drinking; Animals; Autoradiography; Central N | 2003 |
5-HT1A agonists: alcohol drinking in rats and squirrel monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Dose-Response Relationship, Drug; | 2003 |
Ethanol consumption and serotonin-1A (5-HT1A) receptor function in heterozygous BDNF (+/-) mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Autoradiography; Behavior, Animal | 2003 |
Decrease of ethanol intake following repeated injection of serotonin-1A agonist in rats: relationship with receptor responsiveness.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Ethanol; Feedback, Physiological; | 2003 |
Influences of housing conditions and ethanol intake on binding characteristics of D2, 5-HT1A, and benzodiazepine receptors of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Flunitrazepam; Hippocampus; Kinet | 1995 |
Regional serotonin1A receptors in the CNS of alcohol-preferring and -nonpreferring rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Autoradiography; Brain; Brain Che | 1994 |
Low doses of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH DPAT) increase ethanol intake.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Dose-Response Relationship, Drug; | 1994 |
Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats: involvement of presynaptic 5-HT1A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Depression, Chemical; Dose-Respon | 1993 |
Greater abundance of serotonin1A receptor in some brain areas of alcohol-preferring (P) rats compared to nonpreferring (NP) rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Brain Chemistry; Cerebral Cortex; | 1993 |
Effects of acute, chronic ethanol and withdrawal on dorsal raphe neurons: electrophysiological studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Alcoholism; Analysis of Variance; Animals; | 1997 |
Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Amphetamines; Animals; Buspirone; Conditio | 2000 |
Voluntary intake of alcohol is attenuated by ipsapirone in mice and role of 5-HT1A receptor.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Anti-Anxiety Agents; Hippocampus; | 1992 |
Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Alcoholism; Animals; Arousal; Avoidance Le | 1992 |
Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alcohol Drinking; Animals; Dioxanes; Dioxins; Dopamine Antag | 1989 |