8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Aging in 54 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Furthermore, aging does not seem to be associated with a reduced cortical serotonergic innervation, as indicated by the stability of the [3H]paroxetine-labeled 5-HT uptake sites." | 3.68 | Effect of aging in human cortical pre- and postsynaptic serotonin binding sites. ( Arranz, B; Eriksson, A; Marcusson, J; Mellerup, E; Plenge, P, 1993) |
| "Although the use of aging experimental animals for studying serotonergic neuronal changes is limited because of species differences, cholinergic neuronal deterioration does appear to be a feature common to mammalian aging brains." | 3.68 | Serotonergic ligand binding in aging brain of experimental animals. ( Yamagata, A; Yamaguchi, T, 1991) |
| "[3H]sulpiride binding was significantly different only in the ventral tegmental area (VTA), where binding was approximately 20% lower in the periadolescent P rats compared with the NP rat pups." | 1.32 | Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups. ( Li, TK; Lumeng, L; McBride, WJ; Strother, WN, 2003) |
| " We performed acute dose-response and time course behavioral studies in 1-day-old rats with the putative selective agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (5-HT1A), 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H-indole (RU 24969) (5-HT1B), and (+-)1-(2,5-dimethoxy-4-iodo-phenyl aminopropane)-2 (DOI) (5-HT2/1C)." | 1.28 | Serotonin receptor ontogeny: effects of agonists in 1-day-old rats. ( Pranzatelli, MR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.85) | 18.7374 |
| 1990's | 27 (50.00) | 18.2507 |
| 2000's | 22 (40.74) | 29.6817 |
| 2010's | 4 (7.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Petrascheck, M | 1 |
| Ye, X | 1 |
| Buck, LB | 1 |
| Limón-Morales, O | 1 |
| Soria-Fregozo, C | 1 |
| Arteaga-Silva, M | 1 |
| Vázquez-Palacios, G | 1 |
| Bonilla-Jaime, H | 1 |
| Brosda, J | 1 |
| Müller, N | 1 |
| Bert, B | 1 |
| Fink, H | 1 |
| Matsuzaki, H | 1 |
| Izumi, T | 1 |
| Matsumoto, M | 1 |
| Togashi, H | 1 |
| Yamaguchi, T | 2 |
| Yoshida, T | 1 |
| Watanabe, M | 1 |
| Yoshioka, M | 1 |
| Günther, L | 1 |
| Donix, M | 1 |
| Jähkel, M | 1 |
| Oehler, J | 1 |
| Rhoads, DE | 1 |
| Grimes, N | 1 |
| Kaushal, S | 1 |
| Mallari, J | 1 |
| Orlando, K | 1 |
| Duncan, MJ | 2 |
| Hensler, JG | 1 |
| Yohrling IV, GJ | 1 |
| Jiang, GC | 1 |
| DeJohn, MM | 1 |
| Robertson, DJ | 1 |
| Vrana, KE | 1 |
| Cha, JH | 1 |
| Strother, WN | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| McBride, WJ | 1 |
| Fernández-Guasti, A | 2 |
| Ulloa, RE | 2 |
| Nicolini, H | 2 |
| Lazaris, A | 1 |
| Bertrand, F | 1 |
| Lazarus, C | 1 |
| Galani, R | 1 |
| Stemmelin, J | 1 |
| Poirier, R | 1 |
| Kelche, C | 1 |
| Cassel, JC | 1 |
| Cannizzaro, C | 1 |
| Martire, M | 1 |
| Cannizzaro, E | 1 |
| Monastero, R | 1 |
| Gagliano, M | 1 |
| Mineo, A | 1 |
| Provenzano, G | 1 |
| Shayit, M | 1 |
| Yadid, G | 1 |
| Overstreet, DH | 2 |
| Weller, A | 1 |
| McDonald, LM | 1 |
| Moran, PM | 1 |
| Vythelingum, GN | 1 |
| Joseph, MH | 1 |
| Stephenson, JD | 1 |
| Gray, JA | 1 |
| Messier, ML | 1 |
| Li, A | 1 |
| Nattie, EE | 1 |
| Niblock, MM | 1 |
| Kinney, HC | 1 |
| Luce, CJ | 1 |
| Belliveau, RA | 1 |
| Filiano, JJ | 1 |
| Millan, MJ | 1 |
| Gobert, A | 1 |
| Roux, S | 1 |
| Porsolt, R | 1 |
| Meneses, A | 1 |
| Carli, M | 1 |
| Di Cara, B | 1 |
| Jaffard, R | 1 |
| Rivet, JM | 1 |
| Lestage, P | 1 |
| Mocaer, E | 1 |
| Peglion, JL | 1 |
| Dekeyne, A | 1 |
| Piper, BJ | 1 |
| Vu, HL | 1 |
| Safain, MG | 1 |
| Oliver, AJ | 1 |
| Meyer, JS | 1 |
| Santucci, AC | 1 |
| Madeira, E | 1 |
| Burnet, PW | 1 |
| Eastwood, SL | 1 |
| Harrison, PJ | 1 |
| Robson, L | 1 |
| Gower, AJ | 1 |
| Kendall, DA | 1 |
| Marsden, CA | 1 |
| Penev, PD | 2 |
| Zee, PC | 2 |
| Wallen, EP | 2 |
| Turek, FW | 2 |
| Lacour, F | 1 |
| Berger, S | 1 |
| Espinal, J | 1 |
| Duhault, J | 1 |
| Huguet, F | 1 |
| Drieu, K | 2 |
| Piriou, A | 1 |
| Wedderburn, JF | 1 |
| Sillar, KT | 1 |
| Kennedy, AT | 1 |
| Kitchen, I | 1 |
| Hill, RG | 1 |
| Arranz, B | 1 |
| Eriksson, A | 1 |
| Mellerup, E | 1 |
| Plenge, P | 1 |
| Marcusson, J | 1 |
| Dyck, RH | 1 |
| Cynader, MS | 1 |
| Manhães de Castro, R | 1 |
| Bolaños-Jiménez, F | 1 |
| Seguin, L | 1 |
| Sarhan, H | 1 |
| Fillion, G | 1 |
| Laporte, AM | 1 |
| Doyen, C | 1 |
| Nevo, IT | 1 |
| Chauveau, J | 1 |
| Hauw, JJ | 1 |
| Hamon, M | 1 |
| Dugar, A | 1 |
| Lakoski, JM | 2 |
| Nyakas, C | 1 |
| Oosterink, BJ | 1 |
| Keijser, J | 1 |
| Felszeghy, K | 1 |
| de Jong, GI | 1 |
| Korf, J | 1 |
| Luiten, PG | 1 |
| Daws, LC | 1 |
| Schiller, GD | 1 |
| Orbach, J | 1 |
| Janowsky, DS | 1 |
| Teng, GQ | 1 |
| Williams, J | 1 |
| Zhang, L | 1 |
| Purdy, R | 1 |
| Pearce, WJ | 1 |
| Short, J | 1 |
| Wheeler, DL | 1 |
| Ferrari, PF | 1 |
| Lowther, S | 1 |
| Tidbury, H | 1 |
| Greengrass, P | 1 |
| Wilson, CA | 1 |
| Horton, RW | 1 |
| Keck, BJ | 1 |
| White, CL | 1 |
| Kashima, K | 1 |
| Bray, GA | 1 |
| York, DA | 1 |
| Onodera, T | 1 |
| Watanabe, R | 1 |
| Tha, KK | 1 |
| Hayashi, Y | 1 |
| Murayama, T | 1 |
| Okuma, Y | 1 |
| Ono, C | 1 |
| Oketani, Y | 1 |
| Hosokawa, M | 1 |
| Nomura, Y | 1 |
| Andorn, AC | 1 |
| Pappolla, MA | 1 |
| Shirayama, Y | 1 |
| Muneoka, KT | 1 |
| Takigawa, M | 1 |
| Minabe, Y | 1 |
| Tsukada, H | 1 |
| Kakiuchi, T | 1 |
| Nishiyama, S | 1 |
| Ohba, H | 1 |
| Harada, N | 1 |
| Lecci, A | 1 |
| Giuliani, S | 1 |
| Santicioli, P | 1 |
| Maggi, CA | 1 |
| Mokler, DJ | 1 |
| Sullivan, SA | 1 |
| Winterson, BJ | 1 |
| Pranzatelli, MR | 1 |
| Bell, J | 1 |
| Zhang, XN | 1 |
| Whitaker-Azmitia, PM | 1 |
| Yamagata, A | 1 |
| Matsubara, S | 1 |
| Arora, RC | 1 |
| Meltzer, HY | 1 |
| Dillon, KA | 1 |
| Gross-Isseroff, R | 1 |
| Israeli, M | 1 |
| Biegon, A | 1 |
| Spear, LP | 1 |
| Frambes, NA | 1 |
| Goodwin, G | 1 |
| Haensel, SM | 1 |
| Mos, J | 1 |
| Olivier, B | 1 |
| Slob, AK | 1 |
| Chaouloff, F | 1 |
| Serrurrier, B | 1 |
| Mérino, D | 1 |
| Laude, D | 1 |
| Elghozi, JL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Placebo-Controlled Pilot Study in Huntington's Disease (CIT-HD)[NCT00271596] | Phase 2 | 33 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Full Scale Name: The Executive Composite Score (ECS). Definition: Subscales were averaged to compute this composite total score. The ECS is the weighted average of performance on 6 subtests of executive function, including (1) the Controlled Oral Word Association Test, (2) Symbol Digit Modalities test; (3) Stroop Color Word Test (Interference Trial), (4) Trail Making test (Part B), (5) Letter-Number Sequencing, and (6) Animal Naming. Construct Measured: Thinking tasks involving planning, working memory, attention, problem solving, verbal reasoning, inhibition, mental flexibility, and task switching. ECS Scale Range: The ECS score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance on executive functioning tasks. Change Calculation Details: Compares change in executive functioning performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.005 |
| Placebo | 0.172 |
Full Scale Name: Hamilton Rating Scale for Depression (HAM-D). Definition: The Hamilton Rating Scale for Depression is a clinician-administered multiple item questionnaire used to provide an indication of depression. Construct Measured: Depression. HAM-D Score Range: Raw scores may range from 0 to 54, where higher scores indicate worsening mood. Change Calculation Details: Compares change in mood from screening (intake visit) to visit 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.67 |
| Placebo | 1.23 |
Full Scale Name: Letter Number Sequencing (LNS) subtest from the Wechsler Adult Intelligence Scale (WAIS) third edition. Definition: LNS is a task that requires the reordering of an initially unordered set of letters and numbers. Construct Measured: Working memory. LNS Score Range: Raw scores may range from 0 to 21, where lower scores indicate poorer performance in working memory. Change Calculation Details: Compares change in working memory performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.113 |
| Placebo | 0.225 |
Semantic Fluency Score. Definition: The Semantic Fluency Score is the number of words a person can produce given a category, including naming (1) Animal names, (2) Fruit names, (3) Boy names, (4) Girl names, and (5) Vegetable names. Construct Measured: Working memory and verbal initiation. Scale Range: The Semantic Fluency Score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance on working memory tasks. Change Calculation Details: Compares change in working memory performance from visit 2 (week 0) where patients named fruit names to the weighted average of visits 5 (week 12) & 6 (week 15) where patients named girl names and vegetable names respectively for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.386 |
| Placebo | 0.664 |
"Full Scale Name: Stroop Interference subtest from The Stroop Color and Word Test. Definition: Participants are asked to name the ink color in which a word is printed when the word itself (which is irrelevant to the task) is the name of a different color rather than the same color. For example, participants may be asked to say red to the word blue printed in red ink. Constructs Measured: Selective attention, response inhibition, cognitive flexibility, and processing speed. Scale Range: The Stroop Interference score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in attention and processing speed performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) and 6 (week 15) for the citalopram versus placebo cohort." (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.256 |
| Placebo | -0.046 |
Full Scale Name: Hamilton Rating Scale for Depression (HAM-D). Definition: The Hamilton Rating Scale for Depression is a clinician-administered multiple item questionnaire used to provide an indication of depression. Construct Measured: Depression. HAM-D Score Range: Raw scores may range from 0 to 54, where higher scores indicate worsening mood. Change Calculation Details: This analysis was restricted to a subgroup and, accordingly, does not reflect the total number of participants as reported in the Participant Flow. This analysis compares change in mood from screening (intake visit) to visit 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.10 |
| Placebo | 1.50 |
Full Scale Name: The Symbol Digit Modalities Test (SDMT). Definition: The SDMT screens for organic cerebral dysfunction by having the examinee use a reference key to pair specific numbers with given geometric figures in 90 seconds. Construct Measured: Attention, processing speed, and working memory. SDMT Scale Range: Raw scores may range from 0 to 110, where lower scores indicate poorer performance. Change Calculation Details: Compares change in performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) & 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.227 |
| Placebo | -0.170 |
Full Scale Name: The Total Functional Capacity (TFC) subscale from the Unified Huntington's Disease Rating Scale (UHDRS). Definition: The TFC is a score that classifies five stages of Huntington's Disease and five levels of function in the domains of workplace, finances, domestic chores, activities of daily living and requirements for unskilled or skilled care. Construct Measured: Activities of Daily Living. Scale Range: The TFC score ranges from 0 to 13, where lower scores indicate poorer performance in activities of daily living. Change Calculation Details: Compares change in TFC performance from Baseline (week -4) to the weighted average of visits 4 (week 6) and 6 (week 15) for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | -0.54 |
| Placebo | -0.06 |
"Full Scale Name: Trail Making Test Part B (TMT-B). Definition: The TMT-B test requires participants to connect-the-dots of 25 consecutive targets on a sheet of paper where the subject alternates between numbers and letters, going in both numerical and alphabetical order. Constructs Measured: Attention, set shifting, and processing speed. Scale range: The TMT-B score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in attention and processing speed performance from visit 2 (week 0) to the weighted average of visits 5 (week 12) and 6 (week 15) for the citalopram versus placebo cohort." (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.087 |
| Placebo | 0.405 |
Full Scale Name: The Verbal Fluency Score (VFC). Definition: The VFC is the number of words a person can produce given a letter, including (1) Naming words that start with F, A, and S; (2) naming words that start with K, W, and R; (3) naming words that start with V, I, and P; (4) naming words that start with O, G, and B; (5) naming words that start with E, N, and T; and (6) naming words that start with J, C, and S. Construct Measured: Verbal initiation and flexibility. Scale Range: The Verbal Fluency Composite Score ranges from -5 to +5 on a standardized (Z) score scale, where lower scores indicate poorer performance. Change Calculation Details: Compares change in verbal initiation and flexibility from visit 2 (week 0) where patients named words starting with O, G, and B to the weighted average of visits 5 (week 12) and 6 (week 15) where patients named words starting with E, N, and T, and J, C, and S respectively for the citalopram versus placebo cohort. (NCT00271596)
Timeframe: after 15 weeks of treatment
| Intervention | units on a scale (Least Squares Mean) |
|---|---|
| Citalopram | 0.140 |
| Placebo | 0.071 |
54 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Aging
| Article | Year |
|---|---|
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevit | 2007 |
Altered expression of 5-HT1A receptors in adult rats induced by neonatal treatment with clomipramine.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Body Temperature; Clomipra | 2014 |
Modulatory Role of Postsynaptic 5-Hydroxytryptamine Type 1A Receptors in (±)-8-Hydroxy-N,N-dipropyl-2-aminotetralin-Induced Hyperphagia in Mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Disease Models, Animal; Dose-Response Relati | 2015 |
Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Disease | 2009 |
A diverse development of 5-HT1A receptor binding is relevant to behavioral differences observed in adult mice of two genetically closely related inbred strains.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Aging; Analysis of Variance; Animals; Autoradiog | 2010 |
Decision time and perseveration of adolescent rats in the T-maze are affected differentially by buspirone and independent of 5-HT-1A expression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Buspirone; Decision Making; Gene Expression | 2012 |
Aging alters in a region-specific manner serotonin transporter sites and 5-HT(1A) receptor-G protein interactions in hamster brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Autoradiography; Binding, Competitive; Brain | 2002 |
Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Binding, Competitive; Blotting, Western; Bra | 2002 |
Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pups.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Alcohol Drinking; Animals; Autoradiography; Central N | 2003 |
Age differences in the sensitivity to clomipramine in an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Antidepressive Agents, Tricyclic; Clomiprami | 2003 |
Baseline and 8-OH-DPAT-induced release of acetylcholine in the hippocampus of aged rats with different levels of cognitive dysfunction.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Animals; Cognition Disorders; Female; | 2003 |
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diaze | 2003 |
5-HT(1A) receptor subsensitivity in infancy and supersensitivity in adulthood in an animal model of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Body Tem | 2003 |
Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamine; Analysis of Varianc | 2003 |
Inhibition of medullary raphe serotonergic neurons has age-dependent effects on the CO2 response in newborn piglets.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Inhalation; Aging; Animals; Animals, Newborn | 2004 |
The development of the medullary serotonergic system in the piglet.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Binding, Competitive; Bloo | 2004 |
The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Amnesia; Animals; Dialysis; Discrimina | 2004 |
Sex differences on spontaneous alternation in prepubertal rats: implications for an animal model of obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Disease Models, Animal; Fe | 2004 |
Repeated adolescent 3,4-methylenedioxymethamphetamine (MDMA) exposure in rats attenuates the effects of a subsequent challenge with MDMA or a 5-hydroxytryptamine(1A) receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Body Weight; Dose-Response | 2006 |
Anxiogenesis in adult rats treated chronically with cocaine during adolescence: effects of extended abstinence and 8-OH-DPAT treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anxiety Disorders; Brain; Brain Chemistry; C | 2008 |
Detection and quantitation of 5-HT1A and 5-HT2A receptor mRNAs in human hippocampus using a reverse transcriptase-polymerase chain reaction (RT-PCR) technique and their correlation with binding site densities and age.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aging; Amino Acid Isomerases; Base Sequence; Binding | 1994 |
Age-related behavioural, neurochemical and radioligand binding changes in the central 5-HT system of Sprague-Dawley rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Behavior, Animal; Binding, Com | 1993 |
Aging alters the phase-resetting properties of a serotonin agonist on hamster circadian rhythmicity.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Circadian Rhythm; Cricetinae; Dose-Response | 1995 |
8-OH-DPAT induces a selective increase in protein intake in ageing overweight animals.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Diet; Dietary Proteins; Eating; Energy Intak | 1994 |
Decreased cerebral 5-HT1A receptors during ageing: reversal by Ginkgo biloba extract (EGb 761).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Binding Sites; Binding, Competitive; Cell Me | 1994 |
Modulation of rhythmic swimming activity in post-embryonic Xenopus laevis tadpoles by 5-hydroxytryptamine acting at 5HT1a receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Cyproheptadine; Ergolines; Ketanserin; Metam | 1994 |
Assessment of 8-OH-DPAT induced spontaneous tailflicks as an in vivo model of 5-HT1A function in young rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Res | 1993 |
Effect of aging in human cortical pre- and postsynaptic serotonin binding sites.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Aging; Binding Sites; Female; Front | 1993 |
Autoradiographic localization of serotonin receptor subtypes in cat visual cortex: transient regional, laminar, and columnar distributions during postnatal development.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Antiparkinson Agents; Auto | 1993 |
Sub-chronic cold stress reduces 5-HT1A receptor responsiveness in the old but not in the young rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Cold Temperature; Cyclic AMP; Dose-Response | 1996 |
Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aging; Autoradiography; Humans; Ket | 1996 |
Serotonergic function of aging hippocampal CA3 pyramidal neurons: electrophysiological assessment following administration of 5,7-dihydroxytryptamine in the fimbria-fornix and cingulum bundle.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Anesthetics, Intravenous; An | 1997 |
Aging alters the serotonergic modulation of light-induced phase advances in golden hamsters.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Circadian Rhythm; Cricetinae; Light; Male; M | 1997 |
Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Binding Sites; Cerebral Cortex; Cholinergic | 1997 |
Cholinergic/serotonergic interactions in hypothermia: implications for rat models of depression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Body Temperature Regulation; Depressive Diso | 1998 |
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; F | 1998 |
Comparison of the effects of aging on 5-HT7 and 5-HT1A receptors in discrete regions of the circadian timing system in hamsters.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Brain Mapping; Circadian Rhythm; Cricetinae; | 1999 |
The influence of gender and age on neonatal rat hypothalamic 5-HT1A and 5-HT2A receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amygdala; Animals; Animals, Newborn; Female; Gene Exp | 1999 |
Regional heterogeneity of serotonin(1A) receptor inactivation and turnover in the aging female rat brain following EEDQ.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amygdala; Animals; Brain Chemistry; Carbon Dioxide; C | 2000 |
Effect of a serotonin 1-A agonist on food intake of Osborne-Mendel and S5B/P1 rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Dietary Fats; Dose-Response Relationship, Dr | 2000 |
Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Behavior, Animal; Benzazepines; Brain; Depre | 2000 |
Catecholamines inhibit lipid peroxidation in young, aged, and Alzheimer's disease brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aging; Alzheimer Disease; Autopsy; Brain; Catec | 2001 |
Adenosine A2A, 5-HT1A and 5-HT7 receptor in neonatally pregnenolone-treated rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Aging; Animals; Animals, Newborn; Antihypertensiv | 2001 |
Effects of aging on 5-HT(1A) receptors and their functional response to 5-HT(1a) agonist in the living brain: PET study with [carbonyl-(11)C]WAY-100635 in conscious monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Binding, Competitive; Brain; Carbon Radioiso | 2001 |
Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Topical; Aging; Animals; Antihypertensive Ag | 1992 |
Behaviors induced by 5-hydroxytryptophan in neonatal, preweaning, postweaning, and adult Sprague-Dawley rats.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Animals, | 1992 |
Serotonin receptor ontogeny: effects of agonists in 1-day-old rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Amphetamines; Animals; Animals, Newborn; Female; Indo | 1992 |
5-HT3 receptor-active drugs alter development of spinal serotonergic innervation: lack of effect of other serotonergic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Biguanides; Female; Fenfluramine; Hypoglycem | 1992 |
Serotonergic ligand binding in aging brain of experimental animals.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Aging; Animals; Brain; Cell Membrane; Cerebel | 1991 |
Serotonergic measures in suicide brain: 5-HT1A binding sites in frontal cortex of suicide victims.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Aged, 80 and over; Aging; Cerebral Cortex; Fema | 1991 |
Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain postmortem: effects of age and alcohol.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adolescent; Adult; Aged; Aging; Autoradiography; Brain; Cere | 1991 |
Low doses of the 5-HT1A receptor agonist 8-OH-DPAT increase ingestive behavior in late preweanling and postweanling, but not neonatal rat pups.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Animals, Newborn; Animals, Suckling; Body We | 1991 |
Sex behavior of male and female Wistar rats affected by the serotonin agonist 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Ejaculation; Female; Male; Rats; Rats, Inbre | 1991 |
Feeding responses to a high dose of 8-OH-DPAT in young and adult rats: influence of food texture.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animal Feed; Animals; Blood Glucose; Feeding Behavior | 1988 |