8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Aggression in 52 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates." | 7.73 | Serotonin type-1A receptors modulate adolescent, cocaine-induced offensive aggression in hamsters. ( Knyshevski, I; McCann, TE; Melloni, RH; Ricci, LA, 2005) |
| "Hamsters repeatedly exposed to cocaine throughout adolescence display highly escalated offensive aggression compared to saline-treated littermates." | 3.73 | Serotonin type-1A receptors modulate adolescent, cocaine-induced offensive aggression in hamsters. ( Knyshevski, I; McCann, TE; Melloni, RH; Ricci, LA, 2005) |
| "The present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1A (serotonin) (5-HT1A) receptor agonist, alnespirone [S-20499, (S)-N-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-HT1A agonist 8-hydroxy-2- dipropylaminotetralin (8-OH-DPAT), the partial 5-HT1A agonists ipsapirone and buspirone, and the mixed 5-HT1A/1B agonist eltoprazine." | 3.70 | Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. ( de Boer, SF; Koolhaas, JM; Lesourd, M; Mocaer, E, 1999) |
| "These studies examined the neurochemistry and neuroanatomy of the serotonin (5-HT) system innervating the anterior hypothalamus (AH) and the interaction of 5-HT receptor agonists with arginine vasopressin (AVP) in the regulation of offensive aggression in golden hamsters." | 3.70 | Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus). ( Delville, Y; Ferris, CF; Stolberg, T, 1999) |
| "Fluoxetine is a selective serotonin reuptake inhibitor of the neuronal reuptake pump increasing synaptic concentrations of serotonin, and 8-OH-DPAT is a specific serotonin (5-HT1A) receptor agonist." | 1.32 | Effects of acute treatment with 8-OH-DPAT and fluoxetine on aggressive behaviour in male song sparrows (Melospiza melodia morphna). ( Sperry, TS; Thompson, CK; Wingfield, JC, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (1.92) | 18.7374 |
| 1990's | 24 (46.15) | 18.2507 |
| 2000's | 14 (26.92) | 29.6817 |
| 2010's | 11 (21.15) | 24.3611 |
| 2020's | 2 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, Y | 1 |
| Li, H | 1 |
| Zhou, C | 1 |
| Liu, Y | 1 |
| Ma, Z | 1 |
| Ten Eyck, GR | 2 |
| Ten Eyck, LM | 1 |
| Aubert, Y | 2 |
| Allers, KA | 2 |
| Sommer, B | 2 |
| de Kloet, ER | 4 |
| Abbott, DH | 2 |
| Datson, NA | 2 |
| Audero, E | 1 |
| Mlinar, B | 1 |
| Baccini, G | 1 |
| Skachokova, ZK | 1 |
| Corradetti, R | 1 |
| Gross, C | 1 |
| Quadros, IM | 1 |
| Hwa, LS | 1 |
| Shimamoto, A | 1 |
| Carlson, J | 1 |
| DeBold, JF | 1 |
| Miczek, KA | 3 |
| Terranova, JI | 1 |
| Song, Z | 1 |
| Larkin, TE | 1 |
| Hardcastle, N | 1 |
| Norvelle, A | 1 |
| Riaz, A | 1 |
| Albers, HE | 1 |
| Johnson, O | 1 |
| Becnel, J | 1 |
| Nichols, CD | 1 |
| Idova, GV | 1 |
| Davydova, SM | 1 |
| Cervantes, MC | 1 |
| Biggs, EA | 1 |
| Delville, Y | 2 |
| Günther, L | 1 |
| Donix, M | 1 |
| Jähkel, M | 1 |
| Oehler, J | 1 |
| da Veiga, CP | 1 |
| Lucion, AB | 3 |
| de Almeida, RM | 3 |
| Bazovkina, DV | 1 |
| Terenina, EE | 1 |
| Kulikov, AV | 3 |
| Bohl, MA | 1 |
| Lange, JR | 1 |
| Diol, NR | 1 |
| Naumenko, VS | 3 |
| Kozhemyakina, RV | 1 |
| Plyusnina, IF | 1 |
| Popova, NK | 4 |
| Sperry, TS | 1 |
| Thompson, CK | 1 |
| Wingfield, JC | 1 |
| Lai, MK | 1 |
| Tsang, SW | 1 |
| Francis, PT | 1 |
| Esiri, MM | 1 |
| Keene, J | 1 |
| Hope, T | 1 |
| Chen, CP | 1 |
| Hassanain, M | 1 |
| Bhatt, S | 1 |
| Siegel, A | 1 |
| Karl, T | 1 |
| Lin, S | 1 |
| Schwarzer, C | 1 |
| Sainsbury, A | 1 |
| Couzens, M | 1 |
| Wittmann, W | 1 |
| Boey, D | 1 |
| von Hörsten, S | 1 |
| Herzog, H | 1 |
| Veenema, AH | 1 |
| Cremers, TI | 1 |
| Jongsma, ME | 1 |
| Steenbergen, PJ | 1 |
| de Boer, SF | 2 |
| Koolhaas, JM | 2 |
| Plyusnina, IZ | 3 |
| Knyshevski, I | 1 |
| Ricci, LA | 2 |
| McCann, TE | 1 |
| Melloni, RH | 2 |
| Rasakham, K | 1 |
| Grimes, JM | 1 |
| Beckett, S | 1 |
| Marsden, CA | 2 |
| Sánchez, C | 3 |
| Hyttel, J | 2 |
| Korte, SM | 2 |
| Buwalda, B | 2 |
| Meijer, O | 1 |
| Bohus, B | 2 |
| Arnt, J | 2 |
| Moltzen, EK | 2 |
| Mos, J | 3 |
| Olivier, B | 3 |
| Poth, M | 2 |
| Van Oorschot, R | 1 |
| Van Aken, H | 3 |
| Cologer-Clifford, A | 2 |
| Smoluk, SA | 2 |
| Simon, NG | 2 |
| Meijer, OC | 1 |
| Keijser, J | 1 |
| Sluyter, F | 1 |
| van Oortmerssen, G | 1 |
| Joppa, MA | 1 |
| Rowe, RK | 1 |
| Meisel, RL | 1 |
| Lu, SF | 1 |
| Avgustinovich, DF | 1 |
| Kolpakov, VG | 1 |
| Hussain, S | 1 |
| Faccidomo, S | 1 |
| Deckel, AW | 1 |
| Fuqua, L | 1 |
| Moechars, D | 1 |
| Gilis, M | 1 |
| Kuipéri, C | 1 |
| Laenen, I | 1 |
| Van Leuven, F | 1 |
| Lesourd, M | 1 |
| Mocaer, E | 1 |
| Lee, CH | 1 |
| Oh, JI | 1 |
| Park, HD | 1 |
| Kim, HJ | 1 |
| Park, TK | 1 |
| Kim, JS | 1 |
| Hong, CY | 1 |
| Lee, SJ | 1 |
| Ahn, KH | 1 |
| Kim, YZ | 1 |
| Ferris, CF | 1 |
| Stolberg, T | 1 |
| Ferreira, A | 1 |
| Picazo, O | 1 |
| Uriarte, N | 1 |
| Pereira, M | 1 |
| Fernández-Guasti, A | 1 |
| Chiavegatto, S | 1 |
| Dawson, VL | 1 |
| Mamounas, LA | 1 |
| Koliatsos, VE | 1 |
| Dawson, TM | 1 |
| Nelson, RJ | 1 |
| Pruus, K | 1 |
| Skrebuhhova-Malmros, T | 1 |
| Rudissaar, R | 1 |
| Matto, V | 1 |
| Allikmets, L | 1 |
| Beckett, SR | 1 |
| Lawrence, AJ | 1 |
| Marshall, PW | 1 |
| Blanchard, DC | 1 |
| Shepherd, JK | 1 |
| Rodgers, RJ | 1 |
| Blanchard, RJ | 1 |
| Sijbesma, H | 1 |
| Schipper, J | 1 |
| Haug, M | 1 |
| Wallian, L | 1 |
| Brain, PF | 1 |
| Molina, V | 1 |
| Ciesielski, L | 1 |
| Gobaille, S | 1 |
| Isel, F | 1 |
| Mandel, P | 1 |
1 trial available for 8-hydroxy-2-(di-n-propylamino)tetralin and Aggression
| Article | Year |
|---|---|
Reduced serotonin 5-HT1A receptor binding in the temporal cortex correlates with aggressive behavior in Alzheimer disease.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Fema | 2003 |
51 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Aggression
| Article | Year |
|---|---|
Effects of the 5-HT
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Humans; Receptor, Serotonin, 5-HT1A; Se | 2022 |
Serotonin and vasotocin function in territoriality.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anura; Male; Serotonin; Territoriality; | 2020 |
Brain region-specific transcriptomic markers of serotonin-1A receptor agonist action mediating sexual rejection and aggression in female marmoset monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Brain; Callithrix; Drug Administration | 2013 |
Suppression of serotonin neuron firing increases aggression in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Aggression; Animals; Anxiety; Autoradiogr | 2013 |
Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Alcohol Drinking; Animals; Central Nervous Syste | 2014 |
Serotonin and arginine-vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Arginine Vasopressin; Behavior, Animal; | 2016 |
Serotonin modulates vocalizations and territorial behavior in an amphibian.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amphetamines; Animals; Anura; Behavior, Animal; | 2008 |
Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amphetamines; Analysis of Variance; Animals; Dro | 2009 |
Involvement of presynaptic 5-HT(1A) receptors in immunomodulation in conditions of psychoemotional tension.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Antibody Formation; Antibody-Producing | 2010 |
Differential responses to serotonin receptor ligands in an impulsive-aggressive phenotype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis of Variance; Animals; Animals, Newborn; | 2010 |
A diverse development of 5-HT1A receptor binding is relevant to behavioral differences observed in adult mice of two genetically closely related inbred strains.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Aging; Analysis of Variance; Animals; Autoradiog | 2010 |
Social instigation and aggression in postpartum female rats: role of 5-Ht1A and 5-Ht1B receptors in the dorsal raphé nucleus and prefrontal cortex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Female; Postpartum Period; Prefrontal C | 2011 |
Effect of selective agonist of serotonin 5-HT1A receptors on defensive behavior in mice with different predisposition to catalepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis of Variance; Animals; Catalepsy; Dose-R | 2010 |
Chronic systemic administration of serotonergic ligands flibanserin and 8-OH-DPAT enhance HPA axis responses to restraint in female marmosets.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Aggression; Animals; Benzimidaz | 2013 |
Serotonin 5-HT1A receptor in infancy-onset aggression: comparison with genetically defined aggression in adult rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Fear; Rats; Receptor, | 2013 |
Effects of acute treatment with 8-OH-DPAT and fluoxetine on aggressive behaviour in male song sparrows (Melospiza melodia morphna).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Fluoxetine; Male; Sel | 2003 |
Differential modulation of feline defensive rage behavior in the medial hypothalamus by 5-HT1A and 5-HT2 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Aminopyridines; Animals; Behavior, Animal; Cats; | 2003 |
Y1 receptors regulate aggressive behavior by modulating serotonin pathways.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Male; Mice; Mice, Inb | 2004 |
Differences in the effects of 5-HT(1A) receptor agonists on forced swimming behavior and brain 5-HT metabolism between low and high aggressive mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adaptation, Psychological; Aggression; Agonistic Behavior; A | 2005 |
Reduction in 5-HT1A receptor density, 5-HT1A mRNA expression, and functional correlates for 5-HT1A receptors in genetically defined aggressive rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Brain; Dose-Response Relationship, Drug | 2005 |
Serotonin type-1A receptors modulate adolescent, cocaine-induced offensive aggression in hamsters.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Aggression; Analysis of Variance; Animals; Anim | 2005 |
Serotonin-1A receptor activity and expression modulate adolescent anabolic/androgenic steroid-induced aggression in hamsters.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Anabolic Agents; Androgens; Animals; Cricetinae; | 2006 |
Involvement of brain serotonin 5-HT1A receptors in genetic predisposition to aggressive behavior.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis of Variance; Animals; Behavior, Animal; | 2007 |
Computer analysis and quantification of periaqueductal grey-induced defence behaviour.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Escape Reaction; Homocysteine; Image Pr | 1995 |
Isolation-induced aggression in mice: effects of 5-hydroxytryptamine uptake inhibitors and involvement of postsynaptic 5-HT1A receptors.
Topics: 1-Naphthylamine; 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Analysis o | 1994 |
Effects of intracerebroventricular administration of 5-HT receptor agonists on the maternal aggression of rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amphetamines; Analysis of Variance; Animals; Fem | 1994 |
Socially defeated male rats display a blunted adrenocortical response to a low dose of 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Cortex; Aggression; Animals; Behavior, Animal; Cardi | 1995 |
The role of serotonergic mechanisms in inhibition of isolation-induced aggression in male mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Discrimination, Psychological; Dose-Res | 1993 |
The effects of dorsal raphe administration of eltoprazine, TFMPP and 8-OH-DPAT on resident intruder aggression in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Male; Piperazines; Raphe Nuclei; Rats; | 1993 |
The antiaggressive potency of (-)-penbutolol involves both 5-HT1A and 5-HT1B receptors and beta-adrenoceptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Aggression; Animals; Male; Meth | 1996 |
Effects of serotonergic1A and 1B agonists in androgenic versus estrogenic systems for aggression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Androgens; Animals; Estrogens; Male; Mice; Mice, | 1996 |
Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Animals, Wild; Autoradiography; Cortico | 1996 |
Effects of serotonin 1A or 1B receptor agonists on social aggression in male and female Syrian hamsters.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Cricetinae; Female; Male; Quinoxalines; | 1997 |
Serotonin agonist-induced decreases in intermale aggression are dependent on brain region and receptor subtype.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Male; Mice; Motor Activity; Preoptic Ar | 1997 |
8-OH-DPAT in the median raphe, dorsal periaqueductal gray and corticomedial amygdala nucleus decreases, but in the medial septal area it can increase maternal aggressive behavior in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amygdala; Animals; Brain Chemistry; Female; Mate | 1997 |
Specific [3H]8-OH-DPAT binding in brain regions of rats genetically predisposed to various defense behavior strategies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Brain Chemistry; Catalepsy; Genetics, B | 1998 |
Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Dose-Response Relationship, Drug; Ethan | 1998 |
Effects of serotonergic drugs on lateralized aggression and aggressive displays in Anolis carolinensis.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Biguanides; Functional Laterality; Liza | 1998 |
Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Amyloid beta-Protein Precursor; Animals; Behavio | 1998 |
Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Buspirone; Male; Pipe | 1999 |
Pharmacological characterization of LB50016, N-(4-amino)butyl 3-phenylpyrrolidine derivative, as a new 5-HT1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anti-Anxiety Agents; Antidepressive Age | 1999 |
Serotonin regulation of aggressive behavior in male golden hamsters (Mesocricetus auratus).
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Arginine Vasopressin; Behavior, Animal; | 1999 |
Inhibitory effect of buspirone and diazepam, but not of 8-OH-DPAT, on maternal behavior and aggression.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anti-Anxiety Agents; Body Temperature; | 2000 |
Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Brain; Fenclonine; | 2001 |
5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Apomorphine; Behavior, Animal; Buspiron | 2000 |
Attenuation of chemically induced defence response by 5-HT1 receptor agonists administered into the periaqueductal gray.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Exploratory Behavior; Homocysteine; Inj | 1992 |
Evidence for differential effects of 8-OH-DPAT on male and female rats in the Anxiety/Defense Test Battery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Anxiety; Cats; Female; Male; Motor Acti | 1992 |
The effects of intraventricular administration of eltoprazine, 1-(3-trifluoromethylphenyl)piperazine hydrochloride and 8-hydroxy-2-(di-n-propylamino)tetralin on resident intruder aggression in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Avoidance Learning; Exploratory Behavio | 1992 |
Postsynaptic 5-HT1 receptors and offensive aggression in rats: a combined behavioural and autoradiographic study with eltoprazine.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Autoradiograph | 1991 |
Effects of 8-OH-DPAT and fluoxetine on activity and attack by female mice towards lactating intruders.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Brain Chemistry; Fema | 1990 |
Inhibition of mouse killing behavior by serotonin-mimetic drugs: effects of partial alterations of serotonin neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Citalopram; Fenclonine; Fluoxetine; Hyd | 1987 |