8-hydroxy-2-(di-n-propylamino)tetralin has been researched along with Absence Seizure in 17 studies
8-Hydroxy-2-(di-n-propylamino)tetralin: A serotonin 1A-receptor agonist that is used experimentally to test the effects of serotonin.
8-OH-DPAT : A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
| Excerpt | Relevance | Reference |
|---|---|---|
| "The latency to onset of the first seizure was increased 2." | 5.29 | Stimulation of 5-HT1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats. ( Gariboldi, M; Samanin, R; Tutka, P; Vezzani, A, 1996) |
| "), status epilepticus (SE) of limbic seizures produced by kainic acid (KA, 10 mg/kg, i." | 3.73 | 5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats. ( González-Trujano, ME; Hong, E; López-Meraz, ML; Neri-Bazán, L; Rocha, LL, 2005) |
| "Fluoxetine, a serotonin (5-HT) reuptake inhibitor, has been documented to exert a protective action against convulsive seizures in animal models, when administered either systemically, or focally into substantia nigra." | 3.69 | The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin. ( Gale, K; Pasini, A; Tortorella, A, 1996) |
| "This study assessed the effects of a serotonin (5-HT)1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and a 5-HT2 antagonist ketanserin on fully kindled seizures from the hippocampus." | 3.68 | Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1992) |
| "The latency to onset of the first seizure was increased 2." | 1.29 | Stimulation of 5-HT1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats. ( Gariboldi, M; Samanin, R; Tutka, P; Vezzani, A, 1996) |
| "In the present study, we examined the clonic seizure immediately preceding head-weaving behaviour elicited by 8-OH-DPAT (40 mg/kg, ip) administration in mice." | 1.28 | [8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced clonic seizure in mice]. ( Fujii, E; Nomoto, T, 1991) |
| "Postdecapitation convulsions were analyzed in rats after the administration of a variety of adrenergic and serotonergic agents." | 1.27 | Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents. ( Gonzales, DA; Peroutka, SJ; Shapiro, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 8 (47.06) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Heydari, A | 1 |
| Davoudi, S | 1 |
| Tokarski, K | 1 |
| Zahorodna, A | 1 |
| Bobula, B | 1 |
| Hess, G | 1 |
| López-Meraz, ML | 1 |
| González-Trujano, ME | 1 |
| Neri-Bazán, L | 1 |
| Hong, E | 1 |
| Rocha, LL | 1 |
| Pericić, D | 2 |
| Lazić, J | 1 |
| Jazvinsćak Jembrek, M | 1 |
| Svob Strac, D | 1 |
| Strac, DS | 1 |
| Vlainić, J | 1 |
| Kim, DS | 1 |
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Kim, DW | 1 |
| Choi, SY | 1 |
| Kwon, OS | 1 |
| Kang, TC | 1 |
| Sharma, SK | 1 |
| Dakshinamurti, K | 1 |
| Clark, M | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Wada, Y | 2 |
| Nakamura, M | 2 |
| Hasegawa, H | 2 |
| Yamaguchi, N | 2 |
| Pasini, A | 1 |
| Tortorella, A | 1 |
| Gale, K | 1 |
| Gariboldi, M | 1 |
| Tutka, P | 1 |
| Samanin, R | 1 |
| Vezzani, A | 1 |
| Jensen, JB | 1 |
| Mørk, A | 1 |
| Mikkelsen, JD | 1 |
| Moreau, JL | 1 |
| Griebel, G | 1 |
| Jenck, F | 1 |
| Martin, JR | 1 |
| Widmer, U | 1 |
| Haefely, WE | 1 |
| Fujii, E | 1 |
| Nomoto, T | 1 |
| Peroutka, SJ | 1 |
| Gonzales, DA | 1 |
| Shapiro, M | 1 |
17 other studies available for 8-hydroxy-2-(di-n-propylamino)tetralin and Absence Seizure
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
The effect of sertraline and 8-OH-DPAT on the PTZ_induced seizure threshold: Role of the nitrergic system.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Convulsants; Disease Models, | 2017 |
Comparison of the effects of 5-HT1A and 5-HT4 receptor activation on field potentials and epileptiform activity in rat hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzamides; Bridged Bicyclo Compounds, Heterocyclic | 2002 |
5-HT1A receptor agonists modify epileptic seizures in three experimental models in rats.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anticonvulsants; Con | 2005 |
Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Drug Administration Schedule; Drug Th | 2005 |
Zimelidine decreases seizure susceptibility in stressed mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Ket | 2006 |
Seizure activity selectively reduces 5-HT1A receptor immunoreactivity in CA1 interneurons in the hippocampus of seizure-prone gerbils.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Cell Count; Disease Models, A | 2007 |
Suppression of domoic acid induced seizures by 8-(OH)-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dioxanes; Dopamine Antagonists; Dose-Response Relat | 1993 |
Autoradiographic analysis of serotonin receptors and transporter in kindled rat brain.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Autoradiography; Cerebral Cortex; Hippoca | 1993 |
Intra-hippocampal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Cats; Electric Stimulation; Electr | 1993 |
The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Bicuculline; Convulsants; Fencloni | 1996 |
Stimulation of 5-HT1A receptors in the dorsal hippocampus and inhibition of limbic seizures induced by kainic acid in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Electroencephalography; Hippocampu | 1996 |
Chronic antidepressant treatments decrease pro-opiomelanocortin mRNA expression in the pituitary gland: effects of acute stress and 5-HT(1A) receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acute Disease; Animals; Antidepressive Agents; Citalopram; G | 2001 |
Role of serotonin receptor subtype in seizures kindled from the feline hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Anticonvulsants; Cats; Electric Stimu | 1992 |
Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Brain; Cerebral Ventricles; C | 1992 |
[8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)-induced clonic seizure in mice].
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Dose-Response Relationship, Drug; | 1991 |
Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Animals; Buspirone; Death; Dioxan | 1987 |