8-epi-prostaglandin-f2alpha and Pulmonary-Embolism

Post-pulmonary embolism (PE) syndrome occurs in up to 50% of PE patients. The pathophysiology of this syndrome is obscure.. We investigated whether enhanced oxidative stress and prothrombotic state may be involved in post-PE syndrome.. We studied 101 normotensive noncancer PE patients (aged 56.5 ± 13.9 years) on admission, after 5-7 days and after a 3-month anticoagulation, mostly with rivaroxaban. A marker of oxidative stress, 8-isoprostane, endogenous thrombin potential, fibrinolysis proteins, clot lysis time (CLT) and fibrin clot permeability (K. Enhanced oxidative stress and prothrombotic fibrin clot properties could be involved in the pathogenesis of the post-PE syndrome. Elevated growth differentiation factor 15 assessed at 3 months might be a new biomarker of this syndrome.

Topics: Adult; Aged; Biomarkers; Dinoprost; Female; Growth Differentiation Factor 15; Humans; Male; Middle Aged; Oxidative Stress; Pulmonary Embolism; Syndrome; Thrombosis