8-cyclopentyl-1,3-dimethylxanthine has been researched along with Seizures in 13 studies
8-cyclopentyl-1,3-dimethylxanthine: prolongs epileptic seizures in rats
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this research the role of adenosine A1 and A2A receptors of the entorhinal cortex on piriform cortex kindled seizures was investigated." | 7.74 | The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats. ( Fathollahi, Y; Hosseinmardi, N; Mirnajafi-Zadeh, J; Shahabi, P, 2007) |
| "In this study the role of adenosine A1 and A2A receptors of the hippocampal CA1 region on piriform cortex-kindled seizures was investigated in rats." | 7.73 | Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats. ( Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Rezvani, ME; Zeraati, M, 2006) |
| "Adenosine has anticonvulsant effects in various models of seizures." | 3.80 | The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice. ( Mansoori, E; Moezi, L; Niknahad, H; Shafaroodi, H, 2014) |
| " In this study, the role of adenosine A1 receptors of piriform cortex on CA1 hippocampal kindled seizures was studied in rats." | 3.74 | The role of piriform cortex adenosine A1 receptors on hippocampal kindling. ( Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Zeraati, M, 2008) |
| "In this research the role of adenosine A1 and A2A receptors of the entorhinal cortex on piriform cortex kindled seizures was investigated." | 3.74 | The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats. ( Fathollahi, Y; Hosseinmardi, N; Mirnajafi-Zadeh, J; Shahabi, P, 2007) |
| "In this study the effect of adenosine A(1) receptors of the entorhinal cortex (EC) and amygdala on kindled seizures was investigated." | 3.73 | The role of adenosine A(1) receptors in the interaction between amygdala and entorhinal cortex of kindled rats. ( Amini, A; Fathollahi, Y; Mirnajafi-Zadeh, J; Mohammad-Zadeh, M, 2005) |
| "In this study the role of adenosine A1 and A2A receptors of the hippocampal CA1 region on piriform cortex-kindled seizures was investigated in rats." | 3.73 | Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats. ( Fathollahi, Y; Mirnajafi-Zadeh, J; Namvar, S; Rezvani, ME; Zeraati, M, 2006) |
| " In the presence of 8-cyclopentyl-1,3-dimethylxanthine (CPT), an adenosine A(1) receptor antagonist, the occurrence of spontaneous seizure activity was greatly increased as was the duration and intensity of evoked seizures, whilst the postictal depression of basal synaptic transmission was greatly attenuated." | 3.72 | Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. ( Etherington, LA; Frenguelli, BG, 2004) |
| "In this study the role of adenosine A(1) receptors of CA1 region of the hippocampus on amygdala-kindled seizures was investigated in rats." | 3.71 | Anticonvulsant effect of bilateral injection of N6-cyclohexyladenosine into the CA1 region of the hippocampus in amygdala-kindled rats. ( Alasvand Zarasvand, M; Fathollahi, Y; Mirnajafi-Zadeh, J; Palizvan, MR, 2001) |
| "Adenosine is an endogenous inhibitor of excitatory synaptic transmission with potent anticonvulsant properties in the mammalian brain." | 1.35 | Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. ( Boison, D; Dale, N; Etherington, LA; Frenguelli, BG; Irving, AJ; Meechan, L; Patterson, GE, 2009) |
| "8-CPT did not antagonize the seizure protection afforded by CBZ or SV." | 1.29 | Involvement of adenosine in postictal events in rats given electroshock. ( David, J; Joseph, T; Kulkarni, C, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 10 (76.92) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moezi, L | 1 |
| Mansoori, E | 1 |
| Niknahad, H | 1 |
| Shafaroodi, H | 1 |
| Etherington, LA | 2 |
| Patterson, GE | 1 |
| Meechan, L | 1 |
| Boison, D | 1 |
| Irving, AJ | 1 |
| Dale, N | 1 |
| Frenguelli, BG | 2 |
| Rezvani, ME | 2 |
| Mirnajafi-Zadeh, J | 8 |
| Fathollahi, Y | 8 |
| Palizvan, MR | 2 |
| Kulkarni, C | 2 |
| David, J | 2 |
| Joseph, T | 2 |
| Namvar, S | 2 |
| Zeraati, M | 2 |
| Mohammad-Zadeh, M | 2 |
| Javan, M | 1 |
| Jahanshahi, A | 1 |
| Noorbakhsh, SM | 1 |
| Motamedi, F | 1 |
| Amini, A | 1 |
| Hosseinmardi, N | 1 |
| Shahabi, P | 1 |
| Pourgholami, MH | 1 |
| Alasvand Zarasvand, M | 1 |
13 other studies available for 8-cyclopentyl-1,3-dimethylxanthine and Seizures
| Article | Year |
|---|---|
The role of alpha-2 adrenoceptors in the anticonvulsant effects of adenosine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Adenosine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic | 2014 |
Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus.
Topics: Adenosine; Adenosine Kinase; Animals; Animals, Newborn; Astrocytes; Electric Stimulation; Enzyme Inh | 2009 |
Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner.
Topics: Adenosine; Animals; Animals, Newborn; Dihydropyridines; Dose-Response Relationship, Drug; Drug Inter | 2004 |
Changes in neuromodulatory effect of adenosine A1 receptors on piriform cortex field potentials in amygdala kindled rats.
Topics: Adenosine; Amygdala; Animals; Excitatory Postsynaptic Potentials; Kindling, Neurologic; Male; Olfact | 2007 |
Involvement of adenosine in postictal events in rats given electroshock.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Electroshock; Female; Hindlimb | 1994 |
Influence of adenosine, dipyridamole, adenosine antagonists and antiepileptic drugs on EEG after discharge following cortical stimulation.
Topics: Adenosine; Aminophylline; Animals; Anticonvulsants; Cerebral Cortex; Dipyridamole; Electric Stimulat | 1997 |
The role of piriform cortex adenosine A1 receptors on hippocampal kindling.
Topics: Adenosine; Analysis of Variance; Animals; Disease Models, Animal; Drug Interactions; Electric Stimul | 2008 |
The role of adenosine A(1) receptors in mediating the inhibitory effects of low frequency stimulation of perforant path on kindling acquisition in rats.
Topics: Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Analysis of Variance; Animals; | 2009 |
The role of adenosine A(1) receptors in the interaction between amygdala and entorhinal cortex of kindled rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Amygdala; Analysis of | 2005 |
Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor | 2006 |
The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.
Topics: Adenosine; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Elec | 2007 |
Intraperitoneal and intraamygdala N(6)-cyclohexyladenosine suppress hippocampal kindled seizures in rats.
Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; D | 2000 |
Anticonvulsant effect of bilateral injection of N6-cyclohexyladenosine into the CA1 region of the hippocampus in amygdala-kindled rats.
Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Hippocampus; Kindli | 2001 |