8-bromocyclic-gmp and Leukemia--Myeloid--Acute

8-bromocyclic-gmp has been researched along with Leukemia--Myeloid--Acute* in 1 studies

Other Studies

1 other study(ies) available for 8-bromocyclic-gmp and Leukemia--Myeloid--Acute

Article	Year
Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells. Bioorganic & medicinal chemistry letters, 2000, Mar-20, Volume: 10, Issue:6 We report an improved single-step synthesis to generate the membrane-permeant acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cells, a model system for acute myelocytic leukemia, in micromolar doses, while the corresponding non-modified cGMP-analogues were inactive. Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Death; Cell Line; Cell Membrane Permeability; Cyclic GMP; Humans; Leukemia, Experimental; Leukemia, Myeloid, Acute; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	2000

Article

Year

Membrane-permeant, bioactivatable analogues of cGMP as inducers of cell death in IPC-81 leukemia cells.

Bioorganic & medicinal chemistry letters, 2000, Mar-20, Volume: 10, Issue:6

We report an improved single-step synthesis to generate the membrane-permeant acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cells, a model system for acute myelocytic leukemia, in micromolar doses, while the corresponding non-modified cGMP-analogues were inactive.

Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Death; Cell Line; Cell Membrane Permeability; Cyclic GMP; Humans; Leukemia, Experimental; Leukemia, Myeloid, Acute; Rats; Structure-Activity Relationship; Tumor Cells, Cultured

2000