8-bromocyclic-gmp and Dwarfism

8-bromocyclic-gmp has been researched along with Dwarfism* in 1 studies

Other Studies

1 other study(ies) available for 8-bromocyclic-gmp and Dwarfism

Article	Year
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295 Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes. Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bacterial Toxins; Body Water; Bone Development; Crosses, Genetic; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diarrhea; Dwarfism; Enterotoxins; Escherichia coli Proteins; Female; Gene Deletion; Growth Plate; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Osteogenesis; Signal Transduction	1996

Article

Year

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.

Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295

Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bacterial Toxins; Body Water; Bone Development; Crosses, Genetic; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diarrhea; Dwarfism; Enterotoxins; Escherichia coli Proteins; Female; Gene Deletion; Growth Plate; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Osteogenesis; Signal Transduction

1996