8-bromocyclic-gmp and Diarrhea

8-bromocyclic-gmp has been researched along with Diarrhea* in 2 studies

Other Studies

2 other study(ies) available for 8-bromocyclic-gmp and Diarrhea

Article	Year
Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295 Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes. Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bacterial Toxins; Body Water; Bone Development; Crosses, Genetic; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diarrhea; Dwarfism; Enterotoxins; Escherichia coli Proteins; Female; Gene Deletion; Growth Plate; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Osteogenesis; Signal Transduction	1996
Effect of chlorpromazine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin and 8-Br-cyclic GMP in infant mice. Gastroenterology, 1981, Volume: 80, Issue:2 Subcutaneously administered chlorpromazine reduced intestinal fluid accumulation induced by Escherichia coli heat-stable enterotoxin in infant mice. The antisecretory effect of chlorpromazine, although dose related, was, even with high doses, less than that observed with respect to cholera toxin. Whereas 100 micrograms chlorpromazine abolished cholera toxin-induced intestinal secretion almost completely, 500 microgram chlorpromazine (equivalent to 200 microgram/g body wt) lowered secretion induced by heat-stable enterotoxin by only 41%. The effect of chlorpromazine on intestinal secretion was quantitatively similar regardless of whether heat-stable enterotoxin or the cyclic GMP analogue, 8-Br-cyclic GMP, was the secretagogue. This finding, which suggested that the inhibitory effect of chlorpromazine on heat-stable enterotoxin was independent of guanylate cyclase, was confirmed by assaying this enzyme in intestinal homogenates from mice that had been inoculated with chlorpromazine, and also in experiments in which chlorpromazine was added to guanylate cyclase assay mixtures in vitro. Caution is advised before chlorpromazine is routinely adopted for the treatment of all syndromes of watery diarrhea. Topics: Animals; Chlorpromazine; Cholera Toxin; Cyclic GMP; Diarrhea; Enterotoxins; Escherichia coli; Guanylate Cyclase; Hot Temperature; Intestinal Mucosa; Intestines; Mice; Rabbits	1981

Article

Year

Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II.

Science (New York, N.Y.), 1996, Dec-20, Volume: 274, Issue:5295

Cyclic guanosine 3',5'-monophosphate (cGMP)-dependent protein kinases (cGKs) mediate cellular signaling induced by nitric oxide and cGMP. Mice deficient in the type II cGK were resistant to Escherichia coli STa, an enterotoxin that stimulates cGMP accumulation and intestinal fluid secretion. The cGKII-deficient mice also developed dwarfism that was caused by a severe defect in endochondral ossification at the growth plates. These results indicate that cGKII plays a central role in diverse physiological processes.

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Bacterial Toxins; Body Water; Bone Development; Crosses, Genetic; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diarrhea; Dwarfism; Enterotoxins; Escherichia coli Proteins; Female; Gene Deletion; Growth Plate; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Osteogenesis; Signal Transduction

1996

Effect of chlorpromazine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin and 8-Br-cyclic GMP in infant mice.

Gastroenterology, 1981, Volume: 80, Issue:2

Subcutaneously administered chlorpromazine reduced intestinal fluid accumulation induced by Escherichia coli heat-stable enterotoxin in infant mice. The antisecretory effect of chlorpromazine, although dose related, was, even with high doses, less than that observed with respect to cholera toxin. Whereas 100 micrograms chlorpromazine abolished cholera toxin-induced intestinal secretion almost completely, 500 microgram chlorpromazine (equivalent to 200 microgram/g body wt) lowered secretion induced by heat-stable enterotoxin by only 41%. The effect of chlorpromazine on intestinal secretion was quantitatively similar regardless of whether heat-stable enterotoxin or the cyclic GMP analogue, 8-Br-cyclic GMP, was the secretagogue. This finding, which suggested that the inhibitory effect of chlorpromazine on heat-stable enterotoxin was independent of guanylate cyclase, was confirmed by assaying this enzyme in intestinal homogenates from mice that had been inoculated with chlorpromazine, and also in experiments in which chlorpromazine was added to guanylate cyclase assay mixtures in vitro. Caution is advised before chlorpromazine is routinely adopted for the treatment of all syndromes of watery diarrhea.

Topics: Animals; Chlorpromazine; Cholera Toxin; Cyclic GMP; Diarrhea; Enterotoxins; Escherichia coli; Guanylate Cyclase; Hot Temperature; Intestinal Mucosa; Intestines; Mice; Rabbits

1981