8-azidoguanosine-triphosphate and Lung-Neoplasms

8-azidoguanosine-triphosphate has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 8-azidoguanosine-triphosphate and Lung-Neoplasms

Article	Year
Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors. Biochemical and biophysical research communications, 1987, Apr-29, Volume: 144, Issue:2 Photoincorporation of 8N3-[gamma-32P]-GTP into tissue and cell extracts was examined using gel electrophoresis and autoradiography. Decreased photoincorporation into a 45kD band was observed in extracts from mouse lung tumors as compared to normal mouse lung, and in extracts from lung tumor-derived cell lines when compared to isolated bronchiolar epithelial cells. Decreased 45kD photolabelling was also observed in extracts of S49 lymphoma cyc- cells (deficient in Gs alpha, a 45kD GTP binding protein of receptor-coupled adenylate cyclase) when compared to wild type S49 cells. This, and the observation that there was no cholera toxin-catalyzed ADP-ribosylation in the 45kD band of lung tumor extracts, suggests that the 45kD band contains Gs alpha. Topics: Affinity Labels; Animals; Azides; Cell Line; Guanosine Triphosphate; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Weight; Neoplasm Proteins; Phosphorus Radioisotopes; Subcellular Fractions	1987

Article

Year

Decreased incorporation of the photoaffinity probe 8N3-[gamma-32P]-GTP into a 45kD protein in lung tumors.

Biochemical and biophysical research communications, 1987, Apr-29, Volume: 144, Issue:2

Photoincorporation of 8N3-[gamma-32P]-GTP into tissue and cell extracts was examined using gel electrophoresis and autoradiography. Decreased photoincorporation into a 45kD band was observed in extracts from mouse lung tumors as compared to normal mouse lung, and in extracts from lung tumor-derived cell lines when compared to isolated bronchiolar epithelial cells. Decreased 45kD photolabelling was also observed in extracts of S49 lymphoma cyc- cells (deficient in Gs alpha, a 45kD GTP binding protein of receptor-coupled adenylate cyclase) when compared to wild type S49 cells. This, and the observation that there was no cholera toxin-catalyzed ADP-ribosylation in the 45kD band of lung tumor extracts, suggests that the 45kD band contains Gs alpha.

Topics: Affinity Labels; Animals; Azides; Cell Line; Guanosine Triphosphate; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Molecular Weight; Neoplasm Proteins; Phosphorus Radioisotopes; Subcellular Fractions

1987