8-azaxanthine and Urinary-Bladder-Neoplasms

To evaluate the effect of whole bladder wall laser irradiation with intravesical HpD and ascorbic acid on bladder cancer recurrence.. Photodynamic therapy(PDT) was performed by intravesical instillation of hematoporphyrin derivative (HpD) PsD-007 containing ascorbic acid followed by whole bladder wall laser irradiation in 30 post-operative cases of bladder cancer.. The tumour recurrence rate was 23.3% (7/30) on follow-up for 30 months after PDT. No photo-sensitizing effects was found on the skin of patients, nor was retraction of bladder observed in any case of this series.. This method is effective in the prevention of bladder cancer recurrence. Protection from light is not necessary during treatment.

Topics: Adult; Aged; Carcinoma, Transitional Cell; Female; Hematoporphyrin Photoradiation; Hematoporphyrins; Humans; Laser Therapy; Male; Middle Aged; Neoplasm Recurrence, Local; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms