8-azaxanthine and Port-Wine-Stain

Topics: Adolescent; Adult; Female; Hematoporphyrins; Humans; Male; Photochemotherapy; Photosensitizing Agents; Port-Wine Stain; Retrospective Studies

The purpose of this study was to observe the improvements of port-wine stains (PWSs) under photodynamic therapy (PDT) and to further evaluate the safety and efficacy of PDT in the dermatology clinic for the treatment of PWSs.. Total of 75 PWS patients were treated with PDT. The PWS lesions were exposed to the copper vapor laser after intravenous injection of photosensitizer (Photocarcinorin, PsD-007). The lesions were photographed before each session and the therapeutic effects were evaluated by physicians based on the improvements in color, thickness and area of the photographed lesions. A follow-up visit was carried out after 2 months. The improvement rates were classified into 5 grades for quantitation of the therapeutic effects. A decision of termination or continuation of the treatment was then made according to lesion changes.. Patients with PWSs responded remarkably to PDT. The complete clinical remission rate was 57.33% and the effective rate was up to 94.67% in no more than four courses of treatment. Among the completely responded patients, 20.93% were treated with no more than two courses.. PDT is safe and highly effective for the treatment of PWSs in the dermatology clinic.

Topics: Adolescent; Adult; Child; Child, Preschool; Cohort Studies; Esthetics; Facial Dermatoses; Female; Follow-Up Studies; Hematoporphyrins; Humans; Injections, Intravenous; Male; Patient Satisfaction; Photochemotherapy; Photography; Port-Wine Stain; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Young Adult

In this study, a fluorescence method was established to obtain the local concentration of a photosensitizer (PS) based on the realtime fluorescence measurement of skin with port wine stain (PWS) during photodynamic therapy (PDT). This algorithm corrected for the distortions of PS fluorescence spectra imposed by the absorption of melanin and hemoglobin in skin and other factors, which yields a semi-quantitative measurement of PS concentration. Based on this information, a therapeutic effect correlation index (TECI) was proposed as the area under the PS concentration-time curve during PDT. The correlation between TECI and PDT treatment outcome was analyzed from 31 PWS patients. The measured PS fluorescence spectra showed that under the same PS dose, there were clear variations in the concentrations of the PS during PDT. Statistical analysis showed that TECI has a positive correlation with PDT outcome. Patients with a higher TECI value had a better treatment outcome. These results suggest that fluorescence spectroscopy can be used in situ to monitor skin PS concentration during PDT and to provide a valuable diagnostic tool to predict PDT outcome.

Topics: Algorithms; Hematoporphyrins; Hemoglobins; Humans; Melanins; Photochemotherapy; Photosensitizing Agents; Port-Wine Stain; Skin; Spectrometry, Fluorescence; Treatment Outcome

One-hundred and thirty patients (85 female, 45 male) with port-wine stains were treated with photodynamic therapy, also called photochemotherapy, which recently has become acknowledged as effective for a variety of malignant tumors. Probably based on the photochemical reaction with the generation of toxic species, photochemotherapy results in endothelial cell injury and death of abnormal capillaries under overlying epidermis. A retrospective review of 118 available patients with port-wine stains reveals that 98.3 percent responded to photochemotherapy with varying degrees of success after one-time treatment. Results were reported under a simple classification system ranging from ordinary to dilated to posttreatment type. In the ordinary group, the results evaluated as excellent, good, fair, and poor were 37.8, 53.7, 8.5, and 0 percent, respectively, before a second treatment; the treated area was an average of 9.8 (range 7 to 13) cm in diameter. In addition, hypertrophic scars, permanent hyperpigmentation, and hypopigmentation were not seen based on proper parameters. Photochemotherapy offers a potentially efficient and promising choice based on a completely different mechanism from that of selected photothermal therapy with the pulsed-dye laser.

Topics: Adolescent; Adult; Aged; Capillaries; Child; Child, Preschool; Cicatrix, Hypertrophic; Endothelium, Vascular; Female; Hematoporphyrins; Humans; Hyperpigmentation; Hypopigmentation; Injections, Intravenous; Laser Coagulation; Laser Therapy; Male; Middle Aged; Photochemotherapy; Port-Wine Stain; Radiation-Sensitizing Agents; Remission Induction; Retreatment; Retrospective Studies; Skin