8-azaxanthine and Neoplasms

This paper presents the first report in China on the use of luminescence method with hematoporphyrin derivative PSD-007 in the analysis of the exfoliative malignant cells. By this method, pleurorrhea and ascites from 226 suspicious patients were detected. The results showed that its positive rate was 42.23% higher than that of Wright's stain and its positive conformation rate to HE stain could reach as high as 90.2%. Especially, cancer cells could be distinguished from various kinds of non-cancer cells by an objective quantitative analysis of the cellular fluorescent intensity using microfluorophotometer. This new method, being simple, economical and highly specific, is used not only in the qualitative study of the exfoliative tumor cells, but also in the quantitative analysis.

Topics: Ascitic Fluid; Hematoporphyrins; Humans; Luminescent Measurements; Neoplasms; Pleural Effusion; Radiation-Sensitizing Agents