8-azaxanthine and Nasopharyngeal-Neoplasms

8-azaxanthine has been researched along with Nasopharyngeal-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for 8-azaxanthine and Nasopharyngeal-Neoplasms

Article	Year
Effect of photodynamic therapy (PDT) on the expression of pro-apoptotic protein Bak in nasopharyngeal carcinoma (NPC). Lasers in surgery and medicine, 2001, Volume: 29, Issue:1 To investigate the effect of photodynamic therapy (PDT) on expression of the pro-apoptotic gene Bak in nasopharyngeal carcinoma (NPC).. Apoptosis and expression of the pro-apoptotic gene Bak on the tumor tissues from both pre- and post-PDT were determined using the in situ end labeling (ISEL), standard immunohistochemistry technique and western blot, respectively, in 24 patients with either persistent or recurrent NPC after radiotherapy.. Before PDT, apoptotic index (AI) in tumor tissue was 1.2 +/- 0.6. At 6, 12, 24 and 48 hours after PDT, AI were 6.5 +/- 3.1, 23.6 +/- 8.3, 67.2 +/- 14.2 and 89.3 +/- 8.1, respectively. PDT caused apoptosis in a time-dependent fashion. Immunohistochemical assay indicated that 75% (18/24) of the patients had an upgrade expression of Bak protein in their tumor tissues after PDT. Increases in expression of Bak from PDT were also confirmed by western blot analysis.. PDT probably causes NPC cell apoptosis through an upregulation of the pro-apoptotic protein Bak expression. Topics: Adult; Aged; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Blotting, Western; Carcinoma, Squamous Cell; Female; Hematoporphyrins; Humans; Immunohistochemistry; Male; Membrane Proteins; Middle Aged; Nasopharyngeal Neoplasms; Photochemotherapy; Radiation-Sensitizing Agents; Up-Regulation	2001
Effect of photodynamic therapy on selected laboratory values of patients with nasopharyngeal carcinoma. The Annals of otology, rhinology, and laryngology, 1997, Volume: 106, Issue:8 We determined pre- and post-photodynamic therapy (PDT) serum levels of soluble interleukin-2 receptor (SIL-2R) and interleukin-2 (IL-2), as well as activity of natural killer (NK) cells, among 24 patients with either persistent or recurrent nasopharyngeal carcinoma (NPC), using a double-antibody sandwich technique, tritiated thymidine-deoxyribonucleoside incorporation, and iodine 125-uridine-deoxyribonucleoside release techniques, respectively. The results showed that the post-PDT serum level of SIL-2R had significantly declined (p < .0005), while that of IL-2 and the NK cell activity had significantly increased (p < .0005), compared with pre-PDT values, suggesting an immunoenhancing effect of PDT on NPC patients. Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Hematoporphyrins; Humans; Interleukin-2; Killer Cells, Natural; Male; Middle Aged; Nasopharyngeal Neoplasms; Photochemotherapy; Radiation-Sensitizing Agents; Receptors, Interleukin-2	1997

Article

Year

Effect of photodynamic therapy (PDT) on the expression of pro-apoptotic protein Bak in nasopharyngeal carcinoma (NPC).

Lasers in surgery and medicine, 2001, Volume: 29, Issue:1

To investigate the effect of photodynamic therapy (PDT) on expression of the pro-apoptotic gene Bak in nasopharyngeal carcinoma (NPC).. Apoptosis and expression of the pro-apoptotic gene Bak on the tumor tissues from both pre- and post-PDT were determined using the in situ end labeling (ISEL), standard immunohistochemistry technique and western blot, respectively, in 24 patients with either persistent or recurrent NPC after radiotherapy.. Before PDT, apoptotic index (AI) in tumor tissue was 1.2 +/- 0.6. At 6, 12, 24 and 48 hours after PDT, AI were 6.5 +/- 3.1, 23.6 +/- 8.3, 67.2 +/- 14.2 and 89.3 +/- 8.1, respectively. PDT caused apoptosis in a time-dependent fashion. Immunohistochemical assay indicated that 75% (18/24) of the patients had an upgrade expression of Bak protein in their tumor tissues after PDT. Increases in expression of Bak from PDT were also confirmed by western blot analysis.. PDT probably causes NPC cell apoptosis through an upregulation of the pro-apoptotic protein Bak expression.

Topics: Adult; Aged; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Blotting, Western; Carcinoma, Squamous Cell; Female; Hematoporphyrins; Humans; Immunohistochemistry; Male; Membrane Proteins; Middle Aged; Nasopharyngeal Neoplasms; Photochemotherapy; Radiation-Sensitizing Agents; Up-Regulation

2001

Effect of photodynamic therapy on selected laboratory values of patients with nasopharyngeal carcinoma.

The Annals of otology, rhinology, and laryngology, 1997, Volume: 106, Issue:8

We determined pre- and post-photodynamic therapy (PDT) serum levels of soluble interleukin-2 receptor (SIL-2R) and interleukin-2 (IL-2), as well as activity of natural killer (NK) cells, among 24 patients with either persistent or recurrent nasopharyngeal carcinoma (NPC), using a double-antibody sandwich technique, tritiated thymidine-deoxyribonucleoside incorporation, and iodine 125-uridine-deoxyribonucleoside release techniques, respectively. The results showed that the post-PDT serum level of SIL-2R had significantly declined (p < .0005), while that of IL-2 and the NK cell activity had significantly increased (p < .0005), compared with pre-PDT values, suggesting an immunoenhancing effect of PDT on NPC patients.

Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Hematoporphyrins; Humans; Interleukin-2; Killer Cells, Natural; Male; Middle Aged; Nasopharyngeal Neoplasms; Photochemotherapy; Radiation-Sensitizing Agents; Receptors, Interleukin-2

1997