8-azaxanthine and Hyperpigmentation

One-hundred and thirty patients (85 female, 45 male) with port-wine stains were treated with photodynamic therapy, also called photochemotherapy, which recently has become acknowledged as effective for a variety of malignant tumors. Probably based on the photochemical reaction with the generation of toxic species, photochemotherapy results in endothelial cell injury and death of abnormal capillaries under overlying epidermis. A retrospective review of 118 available patients with port-wine stains reveals that 98.3 percent responded to photochemotherapy with varying degrees of success after one-time treatment. Results were reported under a simple classification system ranging from ordinary to dilated to posttreatment type. In the ordinary group, the results evaluated as excellent, good, fair, and poor were 37.8, 53.7, 8.5, and 0 percent, respectively, before a second treatment; the treated area was an average of 9.8 (range 7 to 13) cm in diameter. In addition, hypertrophic scars, permanent hyperpigmentation, and hypopigmentation were not seen based on proper parameters. Photochemotherapy offers a potentially efficient and promising choice based on a completely different mechanism from that of selected photothermal therapy with the pulsed-dye laser.

Topics: Adolescent; Adult; Aged; Capillaries; Child; Child, Preschool; Cicatrix, Hypertrophic; Endothelium, Vascular; Female; Hematoporphyrins; Humans; Hyperpigmentation; Hypopigmentation; Injections, Intravenous; Laser Coagulation; Laser Therapy; Male; Middle Aged; Photochemotherapy; Port-Wine Stain; Radiation-Sensitizing Agents; Remission Induction; Retreatment; Retrospective Studies; Skin