8-aminoguanosine has been researched along with Immunologic-Deficiency-Syndromes* in 1 studies
1 other study(ies) available for 8-aminoguanosine and Immunologic-Deficiency-Syndromes
Article | Year |
---|---|
A canine model of induced purine nucleoside phosphorylase deficiency.
Purine nucleoside phosphorylase (NP EC 2.4.2.1) deficiency in man is associated with selective T cell dysfunction and normal B cell immunity. To create an in-vivo model of this immune deficiency, we administered 8-aminoguanosine to dogs. This water soluble nucleoside was rapidly converted by NP to the more potent product inhibitor 8-aminoguanine, which had a Ki of 0.52 microM. The accumulation of inosine and exogenous deoxyguanosine in plasma provided evidence that administration of 8-aminoguanosine was effectively inhibiting NP activity. Four dogs given 8-aminoguanosine and deoxyguanosine concurrently for 5 consecutive days showed mean reductions in peripheral blood lymphocytes of 65 +/- 9% range (55-75%) over the test period. Granulocytes, red blood cells, and plateletes remained within the normal range. Administration of 8-aminoguanosine to dogs provides a model of NP deficiency that will permit studies of the specific control of lymphopoiesis and in-vivo immune function. Topics: Animals; Blood Cell Count; Deoxyguanosine; Disease Models, Animal; Dogs; Erythrocytes; Guanosine; Immunologic Deficiency Syndromes; Lymphocytes; Phosphotransferases | 1986 |