8-15-leukotriene-b4 and Inflammation

8-15-leukotriene-b4 has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for 8-15-leukotriene-b4 and Inflammation

Article	Year
Hyperalgesia onset latency suggests a hierarchy of action. Brain research, 1987, Oct-13, Volume: 423, Issue:1-2 Hyperalgesia onset latencies of inflammatory mediators were quantified by measuring the threshold of the nociceptive flexion reflex in the rat at 1 min intervals after intradermal injection. Prostaglandin E2 and 8(R), 15(S)-dihydroxyicosa-(5E,9,11,13Z)-tetraenoic acid induced hyperalgesia with short onset latencies, compatible with a direct action on primary afferent nociceptors. Bradykinin, norepinephrine and leukotriene B4 induced hyperalgesia with a significant delay in onset, compatible with their known indirect mechanisms of producing hyperalgesia. We propose that use of this approach, rapid frequent measurement of nociceptive threshold, can be used to determine the hierarchy of action of mediators in hyperalgesic mechanisms. Topics: Animals; Bradykinin; Dinoprostone; Hyperalgesia; Hyperesthesia; Inflammation; Leukotriene B4; Nociceptors; Norepinephrine; Pain; Prostaglandins E; Rats; Rats, Inbred Strains	1987

Article

Year

Hyperalgesia onset latency suggests a hierarchy of action.

Brain research, 1987, Oct-13, Volume: 423, Issue:1-2

Hyperalgesia onset latencies of inflammatory mediators were quantified by measuring the threshold of the nociceptive flexion reflex in the rat at 1 min intervals after intradermal injection. Prostaglandin E2 and 8(R), 15(S)-dihydroxyicosa-(5E,9,11,13Z)-tetraenoic acid induced hyperalgesia with short onset latencies, compatible with a direct action on primary afferent nociceptors. Bradykinin, norepinephrine and leukotriene B4 induced hyperalgesia with a significant delay in onset, compatible with their known indirect mechanisms of producing hyperalgesia. We propose that use of this approach, rapid frequent measurement of nociceptive threshold, can be used to determine the hierarchy of action of mediators in hyperalgesic mechanisms.

Topics: Animals; Bradykinin; Dinoprostone; Hyperalgesia; Hyperesthesia; Inflammation; Leukotriene B4; Nociceptors; Norepinephrine; Pain; Prostaglandins E; Rats; Rats, Inbred Strains

1987