8-11-14-eicosatrienoic-acid and Gastritis--Atrophic

In the present study, 92 people were found to have atrophic gastritis (AG) according to depressed serum levels of pepsinogen I and pepsinogen II in a screening involving 208 Japanese people, participating in a group health check. Serum levels of n-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), were higher in AG than in non-AG individuals, while those of gamma-linolenic acid (GLA) were significantly lower in AG individuals. The odds ratios for high serum DHA and GLA levels in AG subjects were 2.20 (95% C.I.: 1.10-4.39) and 0.34 (95% C.I.: 0.17-0.68), respectively. The above results suggested that GLA plays a role in reducing the incidence of AG, whereas DHA may increase a risk of AG.

Topics: 8,11,14-Eicosatrienoic Acid; Adult; Age Distribution; Aged; Analysis of Variance; Docosahexaenoic Acids; Eicosanoids; Fatty Acids, Unsaturated; Female; gamma-Linolenic Acid; Gastritis, Atrophic; Humans; Japan; Male; Middle Aged; Odds Ratio; Sex Distribution