8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate has been researched along with Neuroblastoma in 5 studies
8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate: intracellular calcium antagonist; RN given refers to parent cpd
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We described here that pentoxifylline (PTX), which is well known to counteract tumor necrosis factor alpha (TNF alpha)-mediated inflammatory responses, augmented TNF alpha-induced neuroblastoma cell differentiation in conjunction with growth inhibition and cell-cycle arrest in G1 phase." | 7.69 | Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. ( Chuen, HL; Shaio, MF; Yang, KD, 1995) |
| "Phospholipid metabolism was studied in N1E-115 neuroblastoma and C6 glioma cells exposed to thapsigargin, a selective inhibitor of endoplasmic reticulum Ca(2+)-ATPase that raises the cytosolic free Ca2+ concentration [Ca2+]i." | 7.69 | Thapsigargin selectively stimulates synthesis of phosphatidylglycerol in N1E-115 neuroblastoma cells and phosphatidylinositol in C6 glioma cells. ( Byers, DM; Cook, HW; Palmer, FB, 1994) |
| " The dose-response curve for this suppression was very similar to that for stimulation of inositol monophosphate (IP1) formation and for stimulation of the initial rise of [Ca2+]i elicited by carbachol." | 5.28 | Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells. ( Nakagawa-Yagi, Y; Nakamura, H; Saito, Y; Takada, Y, 1992) |
| "Choline transport was the major site of action." | 5.28 | Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake. ( Byers, DM; Cook, HW; Palmer, FB; Spence, MW, 1992) |
| "We described here that pentoxifylline (PTX), which is well known to counteract tumor necrosis factor alpha (TNF alpha)-mediated inflammatory responses, augmented TNF alpha-induced neuroblastoma cell differentiation in conjunction with growth inhibition and cell-cycle arrest in G1 phase." | 3.69 | Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP. ( Chuen, HL; Shaio, MF; Yang, KD, 1995) |
| "Phospholipid metabolism was studied in N1E-115 neuroblastoma and C6 glioma cells exposed to thapsigargin, a selective inhibitor of endoplasmic reticulum Ca(2+)-ATPase that raises the cytosolic free Ca2+ concentration [Ca2+]i." | 3.69 | Thapsigargin selectively stimulates synthesis of phosphatidylglycerol in N1E-115 neuroblastoma cells and phosphatidylinositol in C6 glioma cells. ( Byers, DM; Cook, HW; Palmer, FB, 1994) |
| " The dose-response curve for this suppression was very similar to that for stimulation of inositol monophosphate (IP1) formation and for stimulation of the initial rise of [Ca2+]i elicited by carbachol." | 1.28 | Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells. ( Nakagawa-Yagi, Y; Nakamura, H; Saito, Y; Takada, Y, 1992) |
| "Choline transport was the major site of action." | 1.28 | Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake. ( Byers, DM; Cook, HW; Palmer, FB; Spence, MW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, KD | 1 |
| Chuen, HL | 1 |
| Shaio, MF | 1 |
| Palmer, FB | 2 |
| Cook, HW | 2 |
| Byers, DM | 2 |
| Nakagawa-Yagi, Y | 1 |
| Saito, Y | 1 |
| Takada, Y | 1 |
| Nakamura, H | 1 |
| Spence, MW | 1 |
| Yue, TL | 1 |
| Gleason, MM | 1 |
| Hallenbeck, J | 1 |
| Feuerstein, G | 1 |
5 other studies available for 8-(n,n-diethylamino)octyl-3,4,5-trimethoxybenzoate and Neuroblastoma
| Article | Year |
|---|---|
Pentoxifylline augments but does not antagonize TNF alpha-mediated neuroblastoma cell differentiation: modulation of calcium mobilization but not cAMP.
Topics: Acetylcholine; Calcium; Calcium Channel Blockers; Cell Cycle; Cell Differentiation; Cyclic AMP; Down | 1995 |
Thapsigargin selectively stimulates synthesis of phosphatidylglycerol in N1E-115 neuroblastoma cells and phosphatidylinositol in C6 glioma cells.
Topics: Animals; Calcium; Gallic Acid; Glioma; Mice; Neuroblastoma; Oleic Acid; Oleic Acids; Phosphates; Pho | 1994 |
Suppressive effect of carbachol on forskolin-stimulated neurite outgrowth in human neuroblastoma NB-OK1 cells.
Topics: Atropine; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Colforsin; Cyclic AMP; Drug Inter | 1992 |
Calcium-independent effects of TMB-8. Modification of phospholipid metabolism in neuroblastoma cells by inhibition of choline uptake.
Topics: Animals; Calcium; Calcium Channel Blockers; Chlorpromazine; Choline; Gallic Acid; Mice; Neuroblastom | 1992 |
Characterization of platelet-activating factor-induced elevation of cytosolic free-calcium level in neurohybrid NCB-20 cells.
Topics: Animals; Azepines; Calcium; Calcium Channel Blockers; Cerebral Cortex; Cricetinae; Cricetulus; Cytos | 1991 |