8-(4-sulfophenyl)theophylline has been researched along with Anoxemia in 22 studies
8-(4-sulfophenyl)theophylline: adenosine antagonist
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats." | 7.76 | Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010) |
| "Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation." | 7.71 | Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. ( Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ, 2002) |
| " In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2)." | 7.70 | Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. ( Coney, AM; Marshall, JM, 1998) |
| " Adenosine-receptor blockade with 8-(p-sulfophenyl)-theophylline reduced by 50% the maximum hypoxia-induced rise in plasma ANP concentrations." | 7.69 | Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheep. ( Arora, CP; Castro, LC; Koos, BJ; Mason, BA; Ogunyemi, DA, 1995) |
| "In two groups of Saffan-anaesthetized, spontaneously breathing rats we have attempted to identify the peripheral influences of adenosine in mediating the responses evoked by hypoxia by using an adenosine receptor antagonist, 8-sulphophenyltheophylline (8-SPT, 20 mg kg-1 i." | 7.69 | Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. ( Elnazir, BK; Marshall, JM; Thomas, T, 1994) |
| " In Saffan-anaesthetized rats, we have further investigated the mechanisms underlying the vasodilatation induced by adenosine in skeletal muscle by acute systemic hypoxia (breathing 8% O2 for 5 min)." | 7.69 | Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. ( Marshall, JM; Skinner, MR, 1996) |
| "Previous studies suggest that high levels of adenosine may enhance histamine release and contribute to atrioventricular (AV) nodal conduction arrhythmias during anaphylaxis of isolated guinea pig hearts." | 7.67 | Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. ( Heller, LJ; Regal, JF; Trachte, GJ, 1989) |
| " We have investigated how CHU affects cardiovascular responses evoked by acute systemic hypoxia in adult male offspring, recognising that adenosine contributes to hypoxia-induced muscle vasodilatation and bradycardia by acting on A(1) receptors in normal (N) rats." | 3.76 | Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors. ( Coney, AM; Marshall, JM, 2010) |
| " Tissue glucose uptake and cardiovascular characteristics were measured in the short-horned sculpin, Myoxocephalus scorpius, a species exhibiting low blood glucose levels, during normoxia and hypoxia to assess the role of adenosine receptors in the control of glucose uptake and anaerobic metabolism." | 3.74 | The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius. ( Driedzic, WR; MacCormack, TJ, 2007) |
| "Our findings indicate that obese rats possess altered adenosinergic modulation of ventilatory responses to acute and sustained hypoxia in two opposite ways." | 3.73 | Adenosinergic modulation of ventilation in obese zucker rats. ( Farkas, GA; Lee, SD; Nakano, H, 2005) |
| "Adenosine, prostaglandins (PG) and nitric oxide (NO) have all been implicated in hypoxia-evoked vasodilatation." | 3.71 | Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies. ( Abbas, MR; Coney, AM; Marshall, JM; Ray, CJ, 2002) |
| " In anaesthetized rats, we have examined the role of adenosine in vasodilatation evoked in the cerebral cortex by systemic hypoxia (breathing 8 % O2)." | 3.70 | Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia. ( Coney, AM; Marshall, JM, 1998) |
| "We have used the isolated brainstem-spinal cord preparation of the neonatal rat to study the effects of theophylline on the ventilatory response to hypoxia." | 3.69 | Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord. ( Kawai, A; Mückenhoff, K; Okada, Y; Scheid, P, 1995) |
| " Adenosine-receptor blockade with 8-(p-sulfophenyl)-theophylline reduced by 50% the maximum hypoxia-induced rise in plasma ANP concentrations." | 3.69 | Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheep. ( Arora, CP; Castro, LC; Koos, BJ; Mason, BA; Ogunyemi, DA, 1995) |
| "In two groups of Saffan-anaesthetized, spontaneously breathing rats we have attempted to identify the peripheral influences of adenosine in mediating the responses evoked by hypoxia by using an adenosine receptor antagonist, 8-sulphophenyltheophylline (8-SPT, 20 mg kg-1 i." | 3.69 | Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia. ( Elnazir, BK; Marshall, JM; Thomas, T, 1994) |
| " In Saffan-anaesthetized rats, we have further investigated the mechanisms underlying the vasodilatation induced by adenosine in skeletal muscle by acute systemic hypoxia (breathing 8% O2 for 5 min)." | 3.69 | Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia. ( Marshall, JM; Skinner, MR, 1996) |
| "Previous studies suggest that high levels of adenosine may enhance histamine release and contribute to atrioventricular (AV) nodal conduction arrhythmias during anaphylaxis of isolated guinea pig hearts." | 3.67 | Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts. ( Heller, LJ; Regal, JF; Trachte, GJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 13 (59.09) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coney, AM | 3 |
| Marshall, JM | 6 |
| George, EM | 1 |
| Cockrell, K | 1 |
| Adair, TH | 1 |
| Granger, JP | 1 |
| Ray, CJ | 1 |
| Abbas, MR | 1 |
| Lee, SD | 1 |
| Nakano, H | 1 |
| Farkas, GA | 1 |
| Walsh, MP | 1 |
| MacCormack, TJ | 1 |
| Driedzic, WR | 1 |
| Kawai, A | 1 |
| Okada, Y | 1 |
| Mückenhoff, K | 1 |
| Scheid, P | 1 |
| Ogunyemi, DA | 1 |
| Koos, BJ | 3 |
| Arora, CP | 1 |
| Castro, LC | 1 |
| Mason, BA | 2 |
| Thomas, T | 1 |
| Elnazir, BK | 1 |
| Zhu, PJ | 2 |
| Krnjević, K | 2 |
| Walker, DM | 1 |
| Marber, MS | 1 |
| Walker, JM | 1 |
| Yellon, DM | 1 |
| Ervin, MG | 1 |
| Cohen, MV | 1 |
| Walsh, RS | 1 |
| Goto, M | 1 |
| Downey, JM | 1 |
| Chau, A | 1 |
| Ogunyemi, D | 1 |
| Skinner, MR | 1 |
| Matherne, GP | 1 |
| Berr, SS | 1 |
| Headrick, JP | 1 |
| Tani, M | 1 |
| Suganuma, Y | 1 |
| Takayama, M | 1 |
| Hasegawa, H | 1 |
| Shinmura, K | 1 |
| Ebihara, Y | 1 |
| Tamaki, K | 1 |
| Delaey, C | 1 |
| Boussery, K | 1 |
| Van de Voorde, J | 1 |
| Giussani, DA | 1 |
| Gardner, DS | 1 |
| Cox, DT | 1 |
| Fletcher, AJ | 1 |
| Heller, LJ | 1 |
| Trachte, GJ | 1 |
| Regal, JF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Attenuation of Myocardial Dysfunction by N-Acetylcysteine in Infants Undergoing Arterial Switch Procedure[NCT00374088] | Phase 2 | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Maximum serum creatinine over first 3 days postoperative. (NCT00374088)
Timeframe: 72 hours
| Intervention | mg/dL (Mean) |
|---|---|
| Placebo | 0.99 |
| N-acetylcysteine | 0.74 |
Serial cardiac output was measured by thermodilution. The outcome of maximum decline in indexed cardiac output from 1 hour postoperative to lowest output within 24 hours postoperative was then calculated and compared between NAC and placebo groups. (NCT00374088)
Timeframe: 24 hours
| Intervention | L/min/m2 (Mean) |
|---|---|
| Placebo | 0.68 |
| N-acetylcysteine | 0.29 |
Total urine output over the first 24 hours postoperative (NCT00374088)
Timeframe: 24 hours
| Intervention | mL (Mean) |
|---|---|
| Placebo | 96 |
| N-acetylcysteine | 176 |
22 other studies available for 8-(4-sulfophenyl)theophylline and Anoxemia
| Article | Year |
|---|---|
Effects of maternal hypoxia on muscle vasodilatation evoked by acute systemic hypoxia in adult rat offspring: changed roles of adenosine and A1 receptors.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Bradycardia; Endothelium, Vascular; Female; H | 2010 |
Regulation of sFlt-1 and VEGF secretion by adenosine under hypoxic conditions in rat placental villous explants.
Topics: Adenosine; Animals; Chorionic Villi; Enzyme-Linked Immunosorbent Assay; Female; Hypoxia; Placenta; P | 2010 |
Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: in vivo and in vitro studies.
Topics: Adenosine; Animals; Aorta; Cyclooxygenase Inhibitors; Diclofenac; Hypoxia; In Vitro Techniques; Indo | 2002 |
Adenosinergic modulation of ventilation in obese zucker rats.
Topics: Adenosine; Aminophylline; Animals; Carbon Dioxide; Hypercapnia; Hypoxia; Male; Obesity; Oxygen; Oxyg | 2005 |
The role of adenosine in the early respiratory and cardiovascular changes evoked by chronic hypoxia in the rat.
Topics: Adenosine; Animals; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Guanidines; Heart Rate | 2006 |
The impact of hypoxia on in vivo glucose uptake in a hypoglycemic fish, Myoxocephalus scorpius.
Topics: Adenosine; Animals; Atropine; Blood Glucose; Brain Chemistry; Carbohydrate Metabolism; Cardiac Outpu | 2007 |
Theophylline and hypoxic ventilatory response in the rat isolated brainstem-spinal cord.
Topics: Animals; Animals, Newborn; Brain; Hypoxia; In Vitro Techniques; Phrenic Nerve; Purinergic P1 Recepto | 1995 |
Adenosine modulates hypoxia-induced atrial natriuretic peptide release in fetal sheep.
Topics: Adenosine; Animals; Atrial Natriuretic Factor; Blood Pressure; Fetal Blood; Gases; Heart Rate; Hemog | 1995 |
Differentiation of the peripherally mediated from the centrally mediated influences of adenosine in the rat during systemic hypoxia.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Deaminase; Animals; Blood Gas Analysis; Blood Pressure; Hear | 1994 |
Endogenous adenosine deaminase does not modulate synaptic transmission in rat hippocampal slices under normoxic or hypoxic conditions.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Electrophysiology; Hippocampu | 1994 |
Preconditioning in isolated superfused rabbit papillary muscles.
Topics: Animals; Cardiac Pacing, Artificial; Homeostasis; Hypoxia; In Vitro Techniques; Male; Myocardial Stu | 1994 |
Adenosine mediates hypoxic release of arginine vasopressin in fetal sheep.
Topics: Adenosine; Animals; Arginine Vasopressin; Blood Pressure; Fetus; Gases; Heart Rate; Hydrogen-Ion Con | 1994 |
Hypoxia preconditions rabbit myocardium via adenosine and catecholamine release.
Topics: Adenosine; Adrenergic alpha-Antagonists; Animals; Catecholamines; Heart; Hemodynamics; Hypoxia; In V | 1995 |
Adenosine mediates metabolic and cardiovascular responses to hypoxia in fetal sheep.
Topics: Acidosis; Adenosine; Animals; Blood Pressure; Female; Fetus; Glycolysis; Heart Rate; Hypoxia; Pregna | 1995 |
Studies on the roles of ATP, adenosine and nitric oxide in mediating muscle vasodilatation induced in the rat by acute systemic hypoxia.
Topics: 5'-Nucleotidase; Acute Disease; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; E | 1996 |
Integration of vascular, contractile and metabolic responses to hypoxia: effects of maturation and adenosine.
Topics: Adenosine; Aging; Animals; Coronary Circulation; Coronary Vessels; Energy Metabolism; Heart; Hemodyn | 1996 |
Endogenous adenosine on membrane properties of CA1 neurons in rat hippocampal slices during normoxia and hypoxia.
Topics: Adenosine; Adenosine Deaminase; Animals; Electric Stimulation; Hippocampus; Hypoxia; In Vitro Techni | 1997 |
Low concentrations of adenosine receptor blocker decrease protection by hypoxic preconditioning in ischemic rat hearts.
Topics: Adenosine; Adenosine Triphosphate; Animals; Creatine Kinase; Hypoxia; In Vitro Techniques; Ischemic | 1998 |
Role of adenosine and its receptors in the vasodilatation induced in the cerebral cortex of the rat by systemic hypoxia.
Topics: Adenosine; Animals; Blood Flow Velocity; Blood-Brain Barrier; Erythrocytes; Hypoxia; Laser-Doppler F | 1998 |
A retinal-derived relaxing factor mediates the hypoxic vasodilation of retinal arteries.
Topics: Animals; Cattle; Cyclooxygenase Inhibitors; Dinoprost; Electromyography; Eye Proteins; Hydrogen-Ion | 2000 |
Purinergic contribution to circulatory, metabolic, and adrenergic responses to acute hypoxemia in fetal sheep.
Topics: Animals; Blood Glucose; Blood Pressure; Catecholamines; Epinephrine; Female; Femoral Artery; Fetal B | 2001 |
Role of adenosine in hypoxic alterations of anaphylaxis of isolated guinea pig hearts.
Topics: Adenosine; Anaphylaxis; Animals; Antigens; Atrioventricular Node; Coronary Circulation; Guinea Pigs; | 1989 |