7-nitroindazole has been researched along with Seizures in 48 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 7.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " The involvement of neuronal NOS (nNOS) in seizures induced by homocysteine thiolactone has not been studied." | 7.78 | Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats. ( Djuric, D; Hrncić, D; Krstić, D; Macut, D; Rasić-Marković, A; Stanojlović, O; Susić, V, 2012) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 7.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| "Increased neuronal nitric oxide synthase (nNOS) activity was observed during the prodromal period of seizures in various rat brain regions following administration of GABA(A) receptor antagonist, picrotoxin (PCT)." | 7.72 | Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs. ( Jayakumar, R; Rajasekaran, K; Venkatachalam, K, 2003) |
| "We examined the effects of 7-nitroindazole (7-NI) and N-omega-nitro-L-arginine methyl ester (L-NAME) on the endogenous nitric oxide (NO) production in vivo, cerebral hemodynamics, and hippocampal lesions to investigate the different roles between endothelial NOS (eNOS) and neuronal NOS (nNOS) during kainic acid (KA)-induced seizures in newborn rabbits." | 7.71 | Different effects between 7-nitroindazole and L-NAME on cerebral hemodynamics and hippocampal lesions during kainic acid-induced seizures in newborn rabbits. ( Hoshika, A; Katoh, N; Matsuura, K; Miyajima, T; Ohyu, J; Takami, T; Takashima, S; Takei, Y, 2001) |
| "The objective of this study was to evaluate the interaction of the preferential brain nitric oxide synthase (NOS) inhibitor, 7-nitroindazole (7-NI), with conventional antiepileptic drugs (AEDs) against amygdala-kindled seizures in rats." | 7.70 | 7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z, 2000) |
| "The nitric oxide (NO) synthase inhibitor N omega-nitro-L-arginine (NNA) and the putative brain-selective NO synthase inhibitor 7-nitroindazole (7-NI) were used to determine the role of endogenous NO on seizures induced by kainic acid (KA) in rats and KA, pilocarpine, bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice." | 7.69 | Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. ( Davis, W; Penix, LP; Subramaniam, S, 1994) |
| "Aripiprazole is a novel atypical antipsychotic." | 5.42 | The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Aripiprazole was noted to have antiseizure effects in a study on mice, while it induced seizures in a few human case reports." | 5.42 | The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice." | 5.29 | Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. ( Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U, 1996) |
| " Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine." | 3.88 | Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018) |
| " In addition to anxiety and depressive-like behaviors, we previously showed that juvenile SIS increases susceptibility to pentylenetetrazole (PTZ)-induced seizures in mice through enhancing the nitrergic system activity in the hippocampus." | 3.83 | NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice. ( Amini-khoei, H; Amiri, S; Azizi, R; Dehpour, AR; Ghazi-Khansari, M; Haj-Mirzaian, A; Mehr, SE; Momeny, M; Rahimi-Balaei, M; Shirzadian, A; Zarrinrad, G, 2016) |
| " The involvement of neuronal NOS (nNOS) in seizures induced by homocysteine thiolactone has not been studied." | 3.78 | Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats. ( Djuric, D; Hrncić, D; Krstić, D; Macut, D; Rasić-Marković, A; Stanojlović, O; Susić, V, 2012) |
| " Similar to lithium, agmatine plays a protective role in the central nervous system against seizures and has been reported to enhance the effect of different antiepileptic agents." | 3.76 | Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. ( Bahremand, A; Dehpour, AR; Ghasemi, A; Ghasemi, M; Hedayat, T; Khodadad, TK; Payandemehr, B; Rahimian, R; Ziai, P, 2010) |
| " In the present study, the involvement of NO pathway in the anticonvulsant effect of melatonin in pentylenetetrazole (PTZ)-induced clonic seizures was investigated in mice." | 3.73 | Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice. ( Dehpour, AR; Ghahremani, MH; Riazi, K; Tahsili-Fahadan, P; Yahyavi-Firouz-Abadi, N, 2006) |
| "Increased neuronal nitric oxide synthase (nNOS) activity was observed during the prodromal period of seizures in various rat brain regions following administration of GABA(A) receptor antagonist, picrotoxin (PCT)." | 3.72 | Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs. ( Jayakumar, R; Rajasekaran, K; Venkatachalam, K, 2003) |
| "We examined the effects of 7-nitroindazole (7-NI) and N-omega-nitro-L-arginine methyl ester (L-NAME) on the endogenous nitric oxide (NO) production in vivo, cerebral hemodynamics, and hippocampal lesions to investigate the different roles between endothelial NOS (eNOS) and neuronal NOS (nNOS) during kainic acid (KA)-induced seizures in newborn rabbits." | 3.71 | Different effects between 7-nitroindazole and L-NAME on cerebral hemodynamics and hippocampal lesions during kainic acid-induced seizures in newborn rabbits. ( Hoshika, A; Katoh, N; Matsuura, K; Miyajima, T; Ohyu, J; Takami, T; Takashima, S; Takei, Y, 2001) |
| "Administration of tacrine (5 mg/kg ip), an anticholinesterase agent, in rats pretreated (24 h beforehand) with lithium chloride (LiCl; 12 mEq/kg ip) provides a useful experimental model to study limbic seizures and delayed hippocampal damage." | 3.71 | Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat. ( Bagetta, G; Corasaniti, MT; Del Duca, C; Leta, A; Nisticò, R; Paoletti, AM; Rotiroti, D, 2002) |
| "The involvement of the L-arginine-nitric oxide (NO) pathway in the pathogenesis of hyperoxia-induced seizures was studied by using agents controlling NO levels." | 3.70 | L-arginine-NO pathway and CNS oxygen toxicity. ( Bitterman, H; Bitterman, N, 1998) |
| "The objective of this study was to evaluate the interaction of the preferential brain nitric oxide synthase (NOS) inhibitor, 7-nitroindazole (7-NI), with conventional antiepileptic drugs (AEDs) against amygdala-kindled seizures in rats." | 3.70 | 7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z, 2000) |
| "The interaction of 7-nitroindazole (7-NI), a nitric oxide synthase (NOS) inhibitor, with the protective activity of conventional antiepileptics against pentylenetetrazol (PTZ)-induced seizures was tested in mice." | 3.70 | 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Luszczki, J, 2000) |
| "The nitric oxide (NO) synthase inhibitor N omega-nitro-L-arginine (NNA) and the putative brain-selective NO synthase inhibitor 7-nitroindazole (7-NI) were used to determine the role of endogenous NO on seizures induced by kainic acid (KA) in rats and KA, pilocarpine, bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice." | 3.69 | Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. ( Davis, W; Penix, LP; Subramaniam, S, 1994) |
| "The effect of the nitric oxide synthase (NOS) inhibitors N-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI) on seizures induced by N-methyl-D-aspartate (NMDA), pilocarpine (PIL) and pentylenetetrazol (PTZ), as well as on the electroconvulsive threshold was studied in mice." | 3.69 | The role of nitric oxide in chemically- and electrically-induced seizures in mice. ( Baran, L; Przegaliñski, E; Siwanowicz, J, 1996) |
| "Determination of seizure threshold revealed significant enhancement after preconditioning with low dose of PTZ." | 1.51 | The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice. ( Bahramnejad, E; Dehpour, AR; Faghir-Ghanesefat, H; Kazemi Roodsari, S; Keshavarz-Bahaghighat, H; Mokhtari, T; Rajai, N, 2019) |
| "Methadone is a synthetic opioid used to treat opiate withdrawal and addiction." | 1.51 | Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling. ( Aghaei, I; Bahramnejad, E; Dehpour, AR; Kazemi Roodsari, S; Rahimi, N, 2019) |
| "Chloroquine has long been used for the treatment of malaria and rheumatological disorders." | 1.43 | Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice. ( Abkhoo, A; Amiri, S; Boojar, MM; Dehpour, AR; Delazar, S; Hassanipour, M; Ostadhadi, S; Rahimi, N; Shirzadian, A, 2016) |
| "Aripiprazole is a novel atypical antipsychotic." | 1.42 | The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Aripiprazole was noted to have antiseizure effects in a study on mice, while it induced seizures in a few human case reports." | 1.42 | The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. ( Hosseini, M; Moezi, L; Niknahad, H; Oveisi, S; Shafaroodi, H, 2015) |
| "Electroconvulsions were produced in mice by means of an alternating current (50 Hz, 500 V, 25 mA, ear-clip electrodes, 0." | 1.37 | 7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model. ( Dworzański, W; Jaskólska, A; Zółkowska, D; Łuszczki, JJ, 2011) |
| "7-NI prevents convulsions, including 2-amino-4-methylphosphinobutyric acid (glufosinate)-induced convulsions, in experimental models." | 1.35 | Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibition. ( Kikuchi-Utsumi, K; Matsumura, N; Nakaki, T, 2008) |
| "Furthermore, the increase in seizure threshold elicited by adenosine (100 mg/kg i." | 1.35 | Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice. ( Akula, KK; Dhir, A; Kulkarni, SK, 2008) |
| "Experimental seizures are often accompanied by the generation of free radicals that cause lipid peroxidation (LPO), which may subsequently cause neurodegeneration observed in certain types of human epilepsy." | 1.33 | Seizure-induced oxidative stress in rat brain regions: blockade by nNOS inhibition. ( Rajasekaran, K, 2005) |
| " Hence, in the present study, its (100 and 200 mg/kg) action was tested alone and in combination with phenobarbitone (20 mg/kg) and diazepam (0." | 1.32 | Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats. ( Ekambaram, P; Paul, V, 2003) |
| "Kainic acid is an endogenous excitotoxin acting on glutamate receptors, that leads to neurotoxic damage resembling the alterations observed in some neurological disorders." | 1.32 | 7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure. ( Jovanovic, M; Radenovic, L; Selakovic, V; Vasiljevic, I, 2003) |
| "Bupivacaine seizure doses in 7-NI and L-NAME pretreated animals were similar to control but significantly different from each other." | 1.31 | Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine. ( Heavner, JE; Shi, B, 2000) |
| "Latency to seizures was significantly shorter (P<0." | 1.31 | Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation. ( Chavko, M; Keyser, DO; Xing, G, 2001) |
| "In kainic acid (KA)-treated rat brain, the immunoreactivity of heat-shock protein 27 (HSP27) was markedly increased in glia cells of the limbic system." | 1.31 | Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain. ( Che, Y; Han, PL; Lee, JK; Piao, CS, 2001) |
| "The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine." | 1.30 | Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice. ( Masukawa, T; Nakanishi, K; Natsuki, R, 1998) |
| "The kainate-elicited convulsions and NO formation were attenuated in animals pretreated with either 7-nitroindazole, a specific inhibitor of neuronal NO synthase, or diazepam." | 1.29 | Nitric oxide promotes seizure activity in kainate-treated rats. ( Busse, R; Mordvintcev, PI; Mülsch, A; Nielsen, EO; Olesen, SP; Scheel-Krüger, J; Vanin, AF, 1994) |
| "D-CPPene antagonized seizures induced by intracerebroventricular injection of NMDA in mice." | 1.29 | Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions. ( Eblen, F; Klockgether, T; Löschmann, PA; Turski, L; Wüllner, U, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (18.75) | 18.2507 |
| 2000's | 20 (41.67) | 29.6817 |
| 2010's | 19 (39.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aminirad, A | 1 |
| Mousavi, SE | 1 |
| Fakhraei, N | 1 |
| Mousavi, SM | 1 |
| Rezayat, SM | 1 |
| Bahramnjead, E | 1 |
| Kazemi Roodsari, S | 3 |
| Rahimi, N | 3 |
| Etemadi, P | 1 |
| Aghaei, I | 2 |
| Dehpour, AR | 8 |
| Islas-Espinoza, AM | 1 |
| Campos-Rodriguez, C | 1 |
| San Juan, ER | 1 |
| Faghir-Ghanesefat, H | 1 |
| Keshavarz-Bahaghighat, H | 1 |
| Rajai, N | 1 |
| Mokhtari, T | 1 |
| Bahramnejad, E | 2 |
| Gunes, H | 1 |
| Ozdemir, E | 1 |
| Arslan, G | 1 |
| Dastgheib, M | 1 |
| Moezi, L | 3 |
| Hosseini, M | 2 |
| Oveisi, S | 2 |
| Niknahad, H | 2 |
| Shafaroodi, H | 2 |
| Hassanipour, M | 1 |
| Shirzadian, A | 2 |
| Boojar, MM | 1 |
| Abkhoo, A | 2 |
| Delazar, S | 1 |
| Amiri, S | 2 |
| Ostadhadi, S | 1 |
| Zhu, X | 1 |
| Dong, J | 1 |
| Shen, K | 1 |
| Bai, Y | 1 |
| Chao, J | 1 |
| Yao, H | 1 |
| Haj-Mirzaian, A | 1 |
| Amini-khoei, H | 1 |
| Momeny, M | 1 |
| Rahimi-Balaei, M | 1 |
| Zarrinrad, G | 1 |
| Ghazi-Khansari, M | 1 |
| Azizi, R | 1 |
| Mehr, SE | 1 |
| Aslan, A | 1 |
| Yildirim, M | 1 |
| Ayyildiz, M | 1 |
| Güven, A | 1 |
| Agar, E | 1 |
| Bahremand, A | 2 |
| Nasrabady, SE | 1 |
| Ziai, P | 2 |
| Rahimian, R | 2 |
| Hedayat, T | 2 |
| Payandemehr, B | 2 |
| Khodadad, TK | 1 |
| Ghasemi, A | 1 |
| Ghasemi, M | 1 |
| Krushinskii, AL | 1 |
| Kuzenkov, VS | 1 |
| D'yakonova, VE | 1 |
| Reutov, VP | 1 |
| Łuszczki, JJ | 1 |
| Jaskólska, A | 1 |
| Dworzański, W | 1 |
| Zółkowska, D | 1 |
| Hrncić, D | 1 |
| Rasić-Marković, A | 1 |
| Krstić, D | 1 |
| Macut, D | 1 |
| Susić, V | 1 |
| Djuric, D | 1 |
| Stanojlović, O | 1 |
| Xiao, X | 1 |
| Wang, ZZ | 1 |
| Xu, WG | 1 |
| Xiao, K | 1 |
| Cai, ZY | 1 |
| Sun, XJ | 1 |
| Li, RP | 1 |
| Rajasekaran, K | 2 |
| Jayakumar, R | 1 |
| Venkatachalam, K | 1 |
| Radenovic, L | 1 |
| Vasiljevic, I | 1 |
| Selakovic, V | 1 |
| Jovanovic, M | 1 |
| Chavko, M | 2 |
| Auker, CR | 1 |
| McCarron, RM | 1 |
| Vanaja, P | 1 |
| Ekambaram, P | 2 |
| Paul, V | 1 |
| Hagioka, S | 1 |
| Takeda, Y | 1 |
| Zhang, S | 1 |
| Sato, T | 1 |
| Morita, K | 1 |
| Yahyavi-Firouz-Abadi, N | 1 |
| Tahsili-Fahadan, P | 1 |
| Riazi, K | 1 |
| Ghahremani, MH | 1 |
| Luszczki, JJ | 1 |
| Czuczwar, M | 1 |
| Gawlik, P | 1 |
| Sawiniec-Pozniak, G | 1 |
| Czuczwar, K | 1 |
| Czuczwar, SJ | 3 |
| Royes, LF | 1 |
| Fighera, MR | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Fiorenza, NG | 1 |
| Petry, JC | 1 |
| Coelho, RC | 1 |
| Mello, CF | 1 |
| Sardo, P | 1 |
| D'Agostino, S | 1 |
| Carletti, F | 1 |
| Rizzo, V | 1 |
| La Grutta, V | 1 |
| Ferraro, G | 1 |
| Matsumura, N | 1 |
| Kikuchi-Utsumi, K | 1 |
| Nakaki, T | 1 |
| Akula, KK | 1 |
| Dhir, A | 1 |
| Kulkarni, SK | 1 |
| Penix, LP | 1 |
| Davis, W | 1 |
| Subramaniam, S | 2 |
| Mülsch, A | 1 |
| Busse, R | 1 |
| Mordvintcev, PI | 1 |
| Vanin, AF | 1 |
| Nielsen, EO | 1 |
| Scheel-Krüger, J | 1 |
| Olesen, SP | 1 |
| Kirkby, RD | 1 |
| Carroll, DM | 1 |
| Grossman, AB | 1 |
| Smith, SE | 1 |
| Man, CM | 1 |
| Yip, PK | 1 |
| Tang, E | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Eblen, F | 1 |
| Löschmann, PA | 1 |
| Wüllner, U | 1 |
| Turski, L | 1 |
| Klockgether, T | 1 |
| Przegaliñski, E | 1 |
| Baran, L | 1 |
| Siwanowicz, J | 1 |
| Uzbay, IT | 1 |
| Erden, BF | 1 |
| Tapanyigit, EE | 1 |
| Kayaalp, SO | 1 |
| Bitterman, N | 1 |
| Bitterman, H | 1 |
| Masukawa, T | 1 |
| Nakanishi, K | 1 |
| Natsuki, R | 1 |
| Shi, B | 1 |
| Heavner, JE | 1 |
| Borowicz, KK | 2 |
| Kleinrok, Z | 2 |
| Luszczki, J | 1 |
| Xing, G | 1 |
| Keyser, DO | 1 |
| Che, Y | 1 |
| Piao, CS | 1 |
| Han, PL | 1 |
| Lee, JK | 1 |
| Takei, Y | 1 |
| Takashima, S | 1 |
| Ohyu, J | 1 |
| Matsuura, K | 1 |
| Katoh, N | 1 |
| Takami, T | 1 |
| Miyajima, T | 1 |
| Hoshika, A | 1 |
| Bagetta, G | 1 |
| Paoletti, AM | 1 |
| Leta, A | 1 |
| Del Duca, C | 1 |
| Nisticò, R | 1 |
| Rotiroti, D | 1 |
| Corasaniti, MT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
48 other studies available for 7-nitroindazole and Seizures
| Article | Year |
|---|---|
The role of nitric oxide in anticonvulsant effect of nanocurcumine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Convulsants; Curcumin; Dose-Response Relationship, Drug; Indazoles; Male; | 2017 |
Effects of Modafinil on Clonic Seizure Threshold Induced by Pentylenetetrazole in Mice: Involvement of Glutamate, Nitric oxide, GABA, and Serotonin Pathways.
Topics: Animals; Anticonvulsants; Enzyme Inhibitors; Glutamic Acid; Indazoles; Male; Mice; Modafinil; NG-Nit | 2018 |
Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice.
Topics: 4-Aminopyridine; Acute Disease; Animals; Anticonvulsants; Disease Models, Animal; Drug Therapy, Comb | 2018 |
The Possible Role of Nitric Oxide Pathway in Pentylenetetrazole Preconditioning Against Seizure in Mice.
Topics: Animals; Brain; Enzyme Inhibitors; GABA Antagonists; Guanidines; Indazoles; Male; Mice; NG-Nitroargi | 2019 |
Methadone's effects on pentylenetetrazole-induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Guanidines; Indazoles; Ketamine; Male; Methadone; Mic | 2019 |
Coenzyme Q10 increases absence seizures in WAG/Rij rats: The role of the nitric oxide pathway.
Topics: Action Potentials; Animals; Arginine; Dose-Response Relationship, Drug; Electrocorticography; Indazo | 2019 |
Acute and chronic effects of agomelatine on intravenous penthylenetetrazol-induced seizure in mice and the probable role of nitric oxide.
Topics: Acetamides; Administration, Intravenous; Animals; Anticonvulsants; Convulsants; Guanidines; Indazole | 2014 |
The Effects of Sub-Chronic Treatment with Aripiprazole on Pentylenetetrazole- and Electroshock-Induced Seizures in Mice: The Role of Nitric Oxide.
Topics: Animals; Anticonvulsants; Arginine; Aripiprazole; Convulsants; Electroshock; Guanidines; Indazoles; | 2015 |
The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Arginine; Aripiprazole; Convulsants; Dose-Response R | 2015 |
Possible involvement of nitrergic and opioidergic systems in the modulatory effect of acute chloroquine treatment on pentylenetetrazol induced convulsions in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anticonvulsants; Arginine; Chloroquine; Disease M | 2016 |
Neuronal nitric oxide synthase contributes to pentylenetetrazole-kindling-induced hippocampal neurogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Count; Cell Proliferation; Convulsants; Enzyme Inhibitors; Gene Exp | 2016 |
NMDA receptor antagonists attenuate the proconvulsant effect of juvenile social isolation in male mice.
Topics: Age Factors; Animals; Animals, Newborn; Disease Models, Animal; Dizocilpine Maleate; Dose-Response R | 2016 |
Interaction of leptin and nitric oxide pathway on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Arginine; Brain; Convulsants; Electroencephalography; Enzyme Inhibitors; I | 2010 |
Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Cyclic GMP; Disease Models, Animal; Dose-Response R | 2010 |
Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway.
Topics: Agmatine; Analysis of Variance; Animals; Antidepressive Agents; Arginine; Disease Models, Animal; Do | 2010 |
Effect of inhibitors of inducible and neuronal NO synthases on the development of audiogenic stress-induced damage in Krushinskii-Molodkina rats.
Topics: Animals; Enzyme Inhibitors; Guanidines; Indazoles; Male; Nitric Oxide Synthase Type I; Nitric Oxide | 2010 |
7-Nitroindazole, but not NG-nitro-L-arginine, enhances the anticonvulsant activity of pregabalin in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; | 2011 |
Inhibition of the neuronal nitric oxide synthase potentiates homocysteine thiolactone-induced seizures in adult rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homocysteine; Indazo | 2012 |
Cerebral blood flow increase during prolonged hyperbaric oxygen exposure may not be necessary for subsequent convulsion.
Topics: Animals; Blood Flow Velocity; Cerebrovascular Circulation; Electroencephalography; Hyperbaric Oxygen | 2012 |
Increased neuronal nitric oxide synthase (nNOS) activity triggers picrotoxin-induced seizures in rats and evidence for participation of nNOS mechanism in the action of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Ma | 2003 |
7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure.
Topics: Animals; Anticonvulsants; Brain; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Hippocampus; Ind | 2003 |
Relationship between protein nitration and oxidation and development of hyperoxic seizures.
Topics: Animals; Brain; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Hyperbaric Oxygenation; | 2003 |
Demonstrating the dose- and time-related effects of 7-nitroindazole on picrotoxin-induced convulsions, memory formation, brain nitric oxide synthase activity, and nitric oxide concentration in rats.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Indazoles; Male; Memory; Nitric Oxide; Nitric Oxid | 2004 |
Effect of 7-nitroindazole alone and in combination with phenobarbitone and diazepam on picrotoxin-induced convulsions in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Indazoles; Male; Phe | 2003 |
Seizure-induced oxidative stress in rat brain regions: blockade by nNOS inhibition.
Topics: Animals; Brain; Enzyme Inhibitors; Indazoles; Male; Nerve Tissue Proteins; Nitric Oxide Synthase; Ni | 2005 |
Effects of 7-nitroindazole and N-nitro-l-arginine methyl ester on changes in cerebral blood flow and nitric oxide production preceding development of hyperbaric oxygen-induced seizures in rats.
Topics: Animals; Brain; Cerebrovascular Circulation; Electroencephalography; Enzyme Inhibitors; Indazoles; L | 2005 |
Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Drug Therapy, Com | 2006 |
7-Nitroindazole potentiates the anticonvulsant action of some second-generation antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Drug Synergism; Electroshock; Enzyme Inhibitors; Indaz | 2006 |
The role of nitric oxide on the convulsive behavior and oxidative stress induced by methylmalonate: an electroencephalographic and neurochemical study.
Topics: Animals; Anticonvulsants; Arginine; Corpus Striatum; Dose-Response Relationship, Drug; Electroenceph | 2007 |
Lamotrigine differently modulates 7-nitroindazole and L-arginine influence on rat maximal dentate gyrus activation.
Topics: Animals; Anticonvulsants; Arginine; Dentate Gyrus; Electric Stimulation; Enzyme Inhibitors; Indazole | 2008 |
Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibition.
Topics: Aminobutyrates; Animals; Anticonvulsants; Brain; Herbicides; Imidazoles; Indazoles; Male; Mice; Mice | 2008 |
Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice.
Topics: Adenosine; Animals; Anticonvulsants; Arginine; Convulsants; Cyclic AMP; Cyclic Nucleotide Phosphodie | 2008 |
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Bicuculline; Cerebrovascular Circulation; Enzyme Inhi | 1994 |
Nitric oxide promotes seizure activity in kainate-treated rats.
Topics: Amino Acid Oxidoreductases; Animals; Diazepam; Ditiocarb; Indazoles; Iron; Kainic Acid; Male; Nitric | 1994 |
Factors determining proconvulsant and anticonvulsant effects of inhibitors of nitric oxide synthase in rodents.
Topics: Animals; Anticonvulsants; Behavior, Animal; Convulsants; Electroencephalography; Enzyme Inhibitors; | 1996 |
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Topics: Animals; Anticonvulsants; Arginine; Blood Pressure; Citrulline; Disease Models, Animal; Epilepsy; Fe | 1996 |
Effects of 7-nitroindazole, NG-nitro-L-arginine, and D-CPPene on harmaline-induced postural tremor, N-methyl-D-aspartate-induced seizures, and lisuride-induced rotations in rats with nigral 6-hydroxydopamine lesions.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cyclic GMP; Dose-Response Relationship, Drug; Dru | 1996 |
The role of nitric oxide in chemically- and electrically-induced seizures in mice.
Topics: Animals; Convulsants; Electroshock; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Indazoles; Ma | 1996 |
Nitric oxide synthase inhibition attenuates signs of ethanol withdrawal in rats.
Topics: Acoustic Stimulation; Alcoholism; Animals; Arginine; Behavior, Animal; Enzyme Inhibitors; Ethanol; I | 1997 |
L-arginine-NO pathway and CNS oxygen toxicity.
Topics: Animals; Arginine; Central Nervous System; Electroencephalography; Enzyme Inhibitors; Hyperoxia; Ind | 1998 |
Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Enoxacin; Enzyme Inh | 1998 |
Nitric oxide modulation affects the tissue distribution and toxicity of bupivacaine.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Bupivacaine; Drug Interactions; Enzyme Inhibitors | 2000 |
7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Electroshock; Enzyme Inhibitors; Escape Reaction; Indazol | 2000 |
7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions.
Topics: Animals; Anticonvulsants; Avoidance Learning; Clonazepam; Disease Models, Animal; Drug Interactions; | 2000 |
Increased sensitivity to seizures in repeated exposures to hyperbaric oxygen: role of NOS activation.
Topics: Animals; Calcium; Cerebral Cortex; Electroencephalography; Enzyme Activation; Enzyme Inhibitors; Hyp | 2001 |
Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
Topics: Animals; Arginine; Astrocytes; Crystallins; Drug Interactions; Enzyme Inhibitors; Excitatory Amino A | 2001 |
Different effects between 7-nitroindazole and L-NAME on cerebral hemodynamics and hippocampal lesions during kainic acid-induced seizures in newborn rabbits.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cerebrovascular Circulation; Electroencephalography; Enz | 2001 |
Abnormal expression of neuronal nitric oxide synthase triggers limbic seizures and hippocampal damage in rat.
Topics: Animals; Blotting, Western; Cholinesterase Inhibitors; Enzyme Inhibitors; Hippocampus; Indazoles; Li | 2002 |