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7-nitroindazole and Parkinson Disease

7-nitroindazole has been researched along with Parkinson Disease in 13 studies

7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure

Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)

Research Excerpts

ExcerptRelevanceReference
"Treatment with mangiferin and 7-NI significantly increases locomotor parameters in 6-OHDA lesioned rats."1.72Effects of mangiferin and its combination with nNOS inhibitor 7-nitro-indazole (7-NI) in 6-hydroxydopamine (6-OHDA) lesioned Parkinson's disease rats. ( Chaudhary, MJ; Nath, R; Pal, R; Tiwari, PC, 2022)
"Chronic L-DOPA pharmacotherapy in Parkinson's disease is often accompanied by the development of abnormal and excessive movements known as L-DOPA-induced dyskinesia."1.35Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease. ( Del-Bel, EA; Echeverry, MB; Padovan-Neto, FE; Tumas, V, 2009)
"The neuropathological hallmark of Parkinson's disease (PD) is the selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNc)."1.337-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study. ( Benigno, A; Crescimanno, G; Di Giovanni, G; Di Matteo, V; Esposito, E; Giuliano, DA; Pierucci, M, 2006)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (15.38)18.2507
2000's5 (38.46)29.6817
2010's4 (30.77)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Tiwari, PC1
Chaudhary, MJ1
Pal, R1
Nath, R1
Herrero, MT1
Yuste, JE1
Cuenca-Bermejo, L1
Almela, P1
Arenas-Betancur, L1
De Pablos, V1
Gonzalez-Cuello, A1
Del Bel, E1
Navarro-Zaragoza, J1
Fernández-Villalba, E1
Solís, O1
Espadas, I1
Del-Bel, EA2
Moratalla, R1
Bortolanza, M2
Cavalcanti-Kiwiatkoski, R1
Padovan-Neto, FE2
da-Silva, CA2
Mitkovski, M1
Raisman-Vozari, R1
Del-Bel, E2
Kumari, R1
Kumar, JB1
Luthra, PM1
Bariotto-Dos-Santos, KD1
Dos-Santos-Pereira, M1
Di Matteo, V2
Pierucci, M2
Benigno, A2
Crescimanno, G2
Esposito, E2
Di Giovanni, G2
Echeverry, MB1
Tumas, V1
Giuliano, DA1
Rajakumar, B1
Flumerfelt, BA1
Hrycyshyn, AW1
Rajakumar, N1
Haik, KL1
Shear, DA1
Hargrove, C1
Patton, J1
Mazei-Robison, M1
Sandstrom, MI1
Dunbar, GL1
Przedborski, S1
Jackson-Lewis, V1
Yokoyama, R1
Shibata, T1
Dawson, VL1
Dawson, TM1
Snyder, SH1

Other Studies

13 other studies available for 7-nitroindazole and Parkinson Disease

ArticleYear
Effects of mangiferin and its combination with nNOS inhibitor 7-nitro-indazole (7-NI) in 6-hydroxydopamine (6-OHDA) lesioned Parkinson's disease rats.
    Fundamental & clinical pharmacology, 2022, Volume: 36, Issue:6

    Topics: Animals; Male; Nitrites; Oxidopamine; Parkinson Disease; Rats; Rats, Wistar

2022
7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate.
    Open biology, 2023, Volume: 13, Issue:5

    Topics: Animals; Antiparkinson Agents; Dyskinesia, Drug-Induced; Levodopa; Parkinson Disease; Parkinsonian D

2023
Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3(-/-) aphakia mice.
    Neurobiology of disease, 2015, Volume: 73

    Topics: Animals; Antiparkinson Agents; Benserazide; Cell Count; Corpus Striatum; Disease Models, Animal; Dop

2015
Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease.
    Neurobiology of disease, 2015, Volume: 73

    Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Indazoles; Inflamma

2015
Post-lesion administration of 7-NI attenuated motor and non-motor deficits in 6-OHDA induced bilaterally lesioned female rat model of Parkinson's disease.
    Neuroscience letters, 2015, Mar-04, Volume: 589

    Topics: Animals; Brain; Catalase; Dopamine; Female; Glutathione; Indazoles; Lipid Peroxidation; Motor Skills

2015
Antidyskinetic Effect of 7-Nitroindazole and Sodium Nitroprusside Associated with Amantadine in a Rat Model of Parkinson's Disease.
    Neurotoxicity research, 2016, Volume: 30, Issue:1

    Topics: Amantadine; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Dyskinesia,

2016
Involvement of nitric oxide in nigrostriatal dopaminergic system degeneration: a neurochemical study .
    Annals of the New York Academy of Sciences, 2009, Volume: 1155

    Topics: Animals; Corpus Striatum; Indazoles; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Oxidopami

2009
Nitric oxide synthase inhibition attenuates L-DOPA-induced dyskinesias in a rodent model of Parkinson's disease.
    Neuroscience, 2009, Mar-31, Volume: 159, Issue:3

    Topics: Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; En

2009
7-nitroindazole protects striatal dopaminergic neurons against MPP+-induced degeneration: an in vivo microdialysis study.
    Annals of the New York Academy of Sciences, 2006, Volume: 1089

    Topics: 1-Methyl-4-phenylpyridinium; Animals; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Indazoles

2006
Nitric oxide-containing neurons in long-term grafts in a rat model of Parkinson's disease.
    Cell transplantation, 2007, Volume: 16, Issue:5

    Topics: Animals; Behavior, Animal; Brain Tissue Transplantation; Choline; Disease Models, Animal; Female; In

2007
7-nitroindazole attenuates 6-hydroxydopamine-induced spatial learning deficits and dopamine neuron loss in a presymptomatic animal model of Parkinson's disease.
    Experimental and clinical psychopharmacology, 2008, Volume: 16, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dopamine; Indazoles; Learni

2008
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, May-14, Volume: 93, Issue:10

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agents; Enz

1996
No NO prevents parkinsonism.
    Nature medicine, 1996, Volume: 2, Issue:9

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Enzyme Inhi

1996