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7-nitroindazole and Nerve Degeneration

7-nitroindazole has been researched along with Nerve Degeneration in 14 studies

7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure

Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.

Research Excerpts

ExcerptRelevanceReference
"Previous studies have shown that cerebral hypoxia results in increased activity of caspase-9, a key initiator of programmed cell death."1.33Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. ( Delivoria-Papadopoulos, M; Mishra, OP, 2006)
"In kainic acid (KA)-treated rat brain, the immunoreactivity of heat-shock protein 27 (HSP27) was markedly increased in glia cells of the limbic system."1.31Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain. ( Che, Y; Han, PL; Lee, JK; Piao, CS, 2001)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (35.71)18.2507
2000's7 (50.00)29.6817
2010's2 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ehara, A1
Nakadate, K1
Sugimoto, H1
Yoshimoto, K1
Ueda, S1
Singh, BK1
Kumar, V1
Chauhan, AK1
Dwivedi, A1
Singh, S1
Kumar, A1
Singh, D1
Patel, DK1
Ray, RS1
Jain, SK1
Singh, C1
Guevara, BH1
Cespedes, GC1
Cubeddu, LX1
He, Y1
Imam, SZ1
Dong, Z1
Jankovic, J1
Ali, SF1
Appel, SH1
Le, W1
Marks, JD1
Boriboun, C1
Wang, J1
Mishra, OP2
Delivoria-Papadopoulos, M2
Mishra, R1
Ashraf, QM1
Przedborski, S1
Jackson-Lewis, V1
Yokoyama, R1
Shibata, T1
Dawson, VL1
Dawson, TM1
Connop, BP2
Boegman, RJ2
Beninger, RJ2
Jhamandas, K2
Zou, JY1
Martinez, DB1
Neafsey, EJ1
Collins, MA1
Zheng, Y1
Laverty, R1
Itzhak, Y1
Martin, JL1
Ail, SF1
Che, Y1
Piao, CS1
Han, PL1
Lee, JK1

Other Studies

14 other studies available for 7-nitroindazole and Nerve Degeneration

ArticleYear
Role of neuronal nitric oxide synthase in slowly progressive dopaminergic neurodegeneration in the Zitter rat.
    Nitric oxide : biology and chemistry, 2018, 08-01, Volume: 78

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Base Sequence; Caudate Nucleus; Dopamine; Dopaminergic Neur

2018
Neuronal Nitric Oxide Synthase Negatively Regulates Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration.
    Molecular neurobiology, 2017, Volume: 54, Issue:4

    Topics: Animals; Behavior, Animal; Blotting, Western; Caspase 3; Cell Survival; Cytochromes c; Dopaminergic

2017
Treatment with 7-nitroindazole enhances kainic acid induced cholinergic neurotoxicity in the rat striatum: a neuroprotective role for neuronal nitric oxide.
    Cellular and molecular neurobiology, 2002, Volume: 22, Issue:5-6

    Topics: Animals; Cell Death; Choline O-Acetyltransferase; Cholinergic Fibers; Drug Synergism; Enzyme Inhibit

2002
Role of nitric oxide in rotenone-induced nigro-striatal injury.
    Journal of neurochemistry, 2003, Volume: 86, Issue:6

    Topics: Animals; Brain Chemistry; Cell Count; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Administratio

2003
Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-13, Volume: 25, Issue:28

    Topics: Animals; Animals, Newborn; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultu

2005
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets.
    Neuroscience letters, 2006, Jun-19, Volume: 401, Issue:1-2

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain; Brain Chemistry; Caspase 9; Cas

2006
Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets.
    Neuroscience, 2006, Jul-07, Volume: 140, Issue:3

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Infarction;

2006
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, May-14, Volume: 93, Issue:10

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agents; Enz

1996
Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase.
    Neuropharmacology, 1996, Volume: 35, Issue:4

    Topics: Analysis of Variance; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors;

1996
Binge ethanol-induced brain damage in rats: effect of inhibitors of nitric oxide synthase.
    Alcoholism, clinical and experimental research, 1996, Volume: 20, Issue:8

    Topics: Alcoholic Intoxication; Animals; Brain; Brain Damage, Chronic; Enzyme Inhibitors; Ethanol; Hippocamp

1996
Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole.
    Journal of neurochemistry, 1997, Volume: 68, Issue:3

    Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Indazoles; Lamotrigine; Male; Malonates; Nerve Dege

1997
Role of brain nitric oxide in (+/-)3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats.
    Brain research, 1998, Jun-08, Volume: 795, Issue:1-2

    Topics: Animals; Body Temperature; Enzyme Activation; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Indazoles

1998
nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.
    Neuroreport, 2000, Sep-11, Volume: 11, Issue:13

    Topics: Animals; Citrulline; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitor

2000
Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
    Journal of neuroscience research, 2001, Sep-01, Volume: 65, Issue:5

    Topics: Animals; Arginine; Astrocytes; Crystallins; Drug Interactions; Enzyme Inhibitors; Excitatory Amino A

2001