7-nitroindazole has been researched along with Nerve Degeneration in 14 studies
7-nitroindazole: an inhibitor of nitric oxide synthase; exhibits anti-nociceptive activity without increasing blood pressure
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies have shown that cerebral hypoxia results in increased activity of caspase-9, a key initiator of programmed cell death." | 1.33 | Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. ( Delivoria-Papadopoulos, M; Mishra, OP, 2006) |
| "In kainic acid (KA)-treated rat brain, the immunoreactivity of heat-shock protein 27 (HSP27) was markedly increased in glia cells of the limbic system." | 1.31 | Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain. ( Che, Y; Han, PL; Lee, JK; Piao, CS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ehara, A | 1 |
| Nakadate, K | 1 |
| Sugimoto, H | 1 |
| Yoshimoto, K | 1 |
| Ueda, S | 1 |
| Singh, BK | 1 |
| Kumar, V | 1 |
| Chauhan, AK | 1 |
| Dwivedi, A | 1 |
| Singh, S | 1 |
| Kumar, A | 1 |
| Singh, D | 1 |
| Patel, DK | 1 |
| Ray, RS | 1 |
| Jain, SK | 1 |
| Singh, C | 1 |
| Guevara, BH | 1 |
| Cespedes, GC | 1 |
| Cubeddu, LX | 1 |
| He, Y | 1 |
| Imam, SZ | 1 |
| Dong, Z | 1 |
| Jankovic, J | 1 |
| Ali, SF | 1 |
| Appel, SH | 1 |
| Le, W | 1 |
| Marks, JD | 1 |
| Boriboun, C | 1 |
| Wang, J | 1 |
| Mishra, OP | 2 |
| Delivoria-Papadopoulos, M | 2 |
| Mishra, R | 1 |
| Ashraf, QM | 1 |
| Przedborski, S | 1 |
| Jackson-Lewis, V | 1 |
| Yokoyama, R | 1 |
| Shibata, T | 1 |
| Dawson, VL | 1 |
| Dawson, TM | 1 |
| Connop, BP | 2 |
| Boegman, RJ | 2 |
| Beninger, RJ | 2 |
| Jhamandas, K | 2 |
| Zou, JY | 1 |
| Martinez, DB | 1 |
| Neafsey, EJ | 1 |
| Collins, MA | 1 |
| Zheng, Y | 1 |
| Laverty, R | 1 |
| Itzhak, Y | 1 |
| Martin, JL | 1 |
| Ail, SF | 1 |
| Che, Y | 1 |
| Piao, CS | 1 |
| Han, PL | 1 |
| Lee, JK | 1 |
14 other studies available for 7-nitroindazole and Nerve Degeneration
| Article | Year |
|---|---|
Role of neuronal nitric oxide synthase in slowly progressive dopaminergic neurodegeneration in the Zitter rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Base Sequence; Caudate Nucleus; Dopamine; Dopaminergic Neur | 2018 |
Neuronal Nitric Oxide Synthase Negatively Regulates Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration.
Topics: Animals; Behavior, Animal; Blotting, Western; Caspase 3; Cell Survival; Cytochromes c; Dopaminergic | 2017 |
Treatment with 7-nitroindazole enhances kainic acid induced cholinergic neurotoxicity in the rat striatum: a neuroprotective role for neuronal nitric oxide.
Topics: Animals; Cell Death; Choline O-Acetyltransferase; Cholinergic Fibers; Drug Synergism; Enzyme Inhibit | 2002 |
Role of nitric oxide in rotenone-induced nigro-striatal injury.
Topics: Animals; Brain Chemistry; Cell Count; Cerebral Cortex; Corpus Striatum; Dopamine; Drug Administratio | 2003 |
Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.
Topics: Animals; Animals, Newborn; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultu | 2005 |
Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Brain; Brain Chemistry; Caspase 9; Cas | 2006 |
Nitric oxide-mediated mechanism of neuronal nitric oxide synthase and inducible nitric oxide synthase expression during hypoxia in the cerebral cortex of newborn piglets.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cell Death; Cerebral Cortex; Cerebral Infarction; | 2006 |
Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cerebellum; Corpus Striatum; Dopamine; Dopamine Agents; Enz | 1996 |
Attenuation of malonate-induced degeneration of the nigrostriatal pathway by inhibitors of nitric oxide synthase.
Topics: Analysis of Variance; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 1996 |
Binge ethanol-induced brain damage in rats: effect of inhibitors of nitric oxide synthase.
Topics: Alcoholic Intoxication; Animals; Brain; Brain Damage, Chronic; Enzyme Inhibitors; Ethanol; Hippocamp | 1996 |
Malonate-induced degeneration of basal forebrain cholinergic neurons: attenuation by lamotrigine, MK-801, and 7-nitroindazole.
Topics: Animals; Dizocilpine Maleate; Enzyme Inhibitors; Indazoles; Lamotrigine; Male; Malonates; Nerve Dege | 1997 |
Role of brain nitric oxide in (+/-)3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats.
Topics: Animals; Body Temperature; Enzyme Activation; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Indazoles | 1998 |
nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.
Topics: Animals; Citrulline; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitor | 2000 |
Delayed induction of alpha B-crystallin in activated glia cells of hippocampus in kainic acid-treated mouse brain.
Topics: Animals; Arginine; Astrocytes; Crystallins; Drug Interactions; Enzyme Inhibitors; Excitatory Amino A | 2001 |